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| 1 | BH3-only proteins target BCL-xL/MCL-1,not BAX/BAK,to initiate apoptosis显示文摘It has been widely accepted that mitochondria-dependent apoptosis initiates when select BH3-only proteins(BID,BIM,etc.)directly engage and allosterically activate effector proteins BAX/BAK.Here,through reconstitution of cells lacking all eight pro-apoptotic BH3-only proteins,we demonstrate that all BH3-only proteins primarily target the anti-apoptotic BCL-2 proteins BCL-xL/MCL-1,whose simultaneous suppression enables membrane-mediated spontaneous activation of BAX/BAK.BH3-only proteins*apoptotic activities correlate with affinities for BCL-xL/MCL1 instead of abilities to directly activate BAX/BAK.Further,BID and BIM do not distinguish BAX from BAK or accelerate BAX/BAK activation following inactivation of BCL-xL/MCL-1.Remarkably,death ligandinduced apoptosis in cells lacking BH3-only proteins and MCL-1 is fully restored by BID mutants capable of neutralizing BCL-xL,but not direct activation of BAX/BAK.Taken together,our findings provide a'Membrane-mediated Permissive'model,in which the BH3-only proteins only indirectly activate BAX/BAK by neutralizing the anti-apoptotic BCL-2 proteins,and thus allowing BAX/BAK to undergo unimpeded,spontaneous activation in the mitochondrial outer membrane milieu,leading to apoptosis initiation. | Kai Huang Katelyn L.O'Neill Jian Li Wei Zhou Na Han Xiaming Pang Wei Wu Lucas Struble Gloria Borgstahl Zhaorui Liu Liqiana Zhang Xu Luo | 2019 | Cell Research2019，29，11： | 16 |
| 2 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 3 | Country characteristics and foreign direct investment in China: a panel data analysis显示文摘 | Liu Xiaming Song Haiyan Wei Yinqi Romilly Peter | 1997 | Weltwirtschaftliches Archiv1997，133，2： | 1 |
| 4 | Causal Links between Foreign Direet Investment and Trade in China 显示文摘 | Xiaming Liu Chengang Wang Yingqi Wei | 2001 | China Economic Review2001，，12： | 1 |
| 5 | Determinants of Bilateral Trade Flows in OECD Countries: Evidence from Gravity Panel Data Models显示文摘 | Chengang Wang Yingqi Wei Xiaming Liu | 2010 | The World Economy2010，，： | 1 |
| 6 | The impact of foreign direct investment on labour productivity in the Chinese electronics industry显示文摘 | Liu Xiaming D Parker K Vaidya Y Wei | 2001 | International Business Review2001，，10： | 1 |
| 7 | Productivity spillovers from foreign direct investment: evidence from UK industry level panel data 显示文摘 | Liu Xiaming Pamela S Wang Chengqi | 2000 | Journal of International Business Studies2000，31，3： | 1 |
| 8 | An empirical investigation of the causal relationship between openness and economic growth in China显示文摘 | Xiaming Liu Haiyan Song Peter Romilly | 1997 | Applied Economics1997，，12： | 1 |
| 9 | Productivity Spillovers from Foreign Direct Invest- ment: Evidence from UK Industry Level Panel Data 显示文摘 | Liu Xiaming Plamela Siler Wang Chengqi and Wei Yingqi | 2000 | Journal of International Business Studies2000，，31： | 1 |
| 10 | The Regional Distribution of Foreign Direct Investment in China显示文摘 | Yingqi Wei Xiaming Liu David Parker Kirit Vaidya | 1999 | Regional Studies1999，，9： | 1 |
| 11 | Productivity Spillovers from Foreign Direct Investment : Evidence from UK Industry Level Panel Data 显示文摘 | LIU XIAMING PAMELA S WANG CHENGQIANG etal | 2000 | Journal of International Business Studies2000，，31： | 1 |
| 12 | Foreign direct investment and productivity spillovers in the Chinese manufacturing sector显示文摘 | Xiaoying Li Xiaming Liu David Parker | 2001 | Economic Systems2001，25，2001： | 1 |
| 13 | Productivity spillovers from foreign direct investment:Evidence from UK industry level panel data 显示文摘 | LIU XIAMING PAMELA SILER WANG CHENGQI WEI YINGQI | 2000 | Journal of International Business Studies2000，，31： | 1 |
| 14 | Pro-ductivity Spillovers from Foreign Direct Investment:Evidence from UK Industry Level Panel Data显示文摘 | Liu Xiaming Pamela Siler Wang Chengqi and Wei Yingqi | 2000 | Journal of International Business Studies2000，31，： | 1 |
| 15 | Productivity Spillovers from Foreign Direct Investment: Evidence from UK Industry Level Panel Data显示文摘 | LiU Xiaming Pamela Siler Chengqi wang and Yingqi Wei | 2000 | Journal of International Business Studies2000，，31： | 1 |
| 16 | The regiona1 distribution of foreign direct investment in China显示文摘 | YINGQI WEI XIAMING LIU PARKER DAVID VAIDYA KIRIT | 1999 | Regional studies1999，33，： | 1 |
| 17 | Productivity Spillovers from R&D,Exports and FDI in China's Manufacturing Sector显示文摘 | Wei Yingqi Xiaming Liu | | 0，，04： | 1 |
| 18 | Foreign direct investment and productivity spillovers in the Chinese manufacturing sector 显示文摘 | Li Xiaoying Liu Xiaming David P | 2001 | Economic System2001，，25： | 1 |
| 19 | Strength and corro- sion properties of portland cement mortar and concrete with min- eral admixtures 显示文摘 | Shi Xiaming Yang Zhengxian Liu Yajun | 2011 | Construction and Building Materials2011，25，8： | 1 |
| 20 | Synthesis and characterization of sulfonated poly (phthalazinone ether sulfone ketone) for ultrafiltration and nanofltration membranes显示文摘 | Dai Ying Jin Xigao Liu Xiaming | 2001 | Journal of Applied Polymer Science2001，79，9： | 1 |
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