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| 1 | Clinical application of specific antibody against glypican-3 for hepatocellular carcinoma diagnosis显示文摘Glypican-3(GPC3) is a promising tumor marker for hepatocellular carcinoma(HCC) diagnosis with high sensitivity and specificity.The aim of this study was to establish an immunohistochemical detection method for GPC3 using the 7D11 monoclonal antibody(7D11 mAb) and evaluate its application for HCC diagnosis.The feasibility of the 7D11 mAb was evaluated by immunohistochemistry performed on adjacent normal liver and intrahepatic cholangiocarcinoma(ICC) samples,Furthermore,the serum GPC3 levels were evaluated in 40 HCC patients,7 ICC patients and 50 healthy donors.The results showed that GPC3 was expressed in 85% of HCC tissues(34/40),but was undetectable in ICC tissues and adjacent normal tissues.GPC3 was significantly increased in the serum of HCC patients(17/40,42.5%) but was undetectable in the serum of ICC patients(0/7,0%) and healthy donors(0/50,0%).This prospective study evaluated the clinical usefulness of 7D11 mAb for GPC3 detection in HCC patients.In conclusion,the use of 7D11 mAb might be good for GPC3 large-scale applications for clinical diagnosis of HCC. | YU JuanPing MA Qiang ZHANG Bin MA RuiJuan XU XiGuang LI MingSong XU WeiWen LI Ming | 2013 | Science China(Life Sciences)2013，56，3： | 18 |
| 2 | Petrology and ^(40)Ar/^(39)Ar iso-topic ages of blueschists in Gangmar, central Qiangtang, northern Tibet显示文摘The petrology and mineral assemblages of blueschists in the Gangmar, central Qiangtang, northern Tibet were examined, which indicates that the metamorphic condition is high-pressure low-temperature. In this note, we reported the 40Ar/39Ar dating results of glaucophane from two blueschist samples. Their apparent ages are (275.0±1.3) Ma and (287.6±2.3) Ma and similar isochron ages are (275.0±0.9) Ma and (282.4±0.8) Ma, respectively. These iso-topic datings show the high-pressure metamorphism occurring in Lower Permian. The ages also coincide with the evolution of Palaeo-Tethys ocean in Late Palaeozoic. | DENG Xiguang, DING Lin, LIU Xiaohan & ZHOU YongLaboratory of Lithospheric Tectonic Evolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2001 | Chinese Science Bulletin2001，46，5： | 13 |
| 3 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 4 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 5 | Recent Progress on Engineering Highly Efficient Porous Semiconductor Photocatalysts Derived from Metal–Organic Frameworks显示文摘Porous structures o er highly accessible surfaces and rich pores, which facilitate the exposure of numerous active sites for photocatalytic reactions, leading to excellent performances. Recently, metal–organic frameworks(MOFs) have been considered ideal precursors for well-designed semiconductors with porous structures and/or heterostructures, which have shown enhanced photocatalytic activities. In this review, we summarize the recent development of porous structures, such as metal oxides and metal sulfides, and their heterostructures, derived from MOF-based materials as catalysts for various light-driven energy-/environment-related reactions, including water splitting, CO_2 reduction, organic redox reaction, and pollution degradation. A summary and outlook section is also included. | Wenwen Zhan Liming Sun Xiguang Han | 2019 | Nano-Micro Letters2019，11，1： | 9 |
| 6 | Preparation and Charaterization of Self-assembled Nanoparticles Based on Linolenic-acid Modified Chitosan显示文摘Chitosan was modified by conjugating coupling with linolenic acid through the l-ethyl-3-( 3-dimethylami-nopropyyl) carbodiimmide (EDC)-mediated reaction. The degree of substitution 1.8% (i.e. 1.8 linolenic acid group per 100anhydroglucose units) was measured by 1H NMR. The critical aggregation concentration (CAC) of the self-aggregate of hy-drophobically modified chitosan was determined by measuring the fluorescence intensity of the pyrene as a fluorescent probe.The CAC value in phosphate-buffered saline (PBS) solution (pH7.4) was 5 × 10-2 mg mL-1. The average particle size of self-aggregates of hydrophobically modified chitosan in PBS solution (pH7.4) was 210.8 nm with a unimodal size distributionranging from 100 to 500 nm. Transmission electron microscopy (TEM) study showed that the formation of near sphericalshape nanoparticles has enough structural integrity. The loading ability of hydrophibically modified chitosan (LA-chitosan)was investigated by using bovine serum albumin (BSA) as the model. The loading capacity of self-aggregated nanoparticlesincreases (19.85% ±0.04% to 37.57% ±0.25%) with the concentration of BSA (0.1-0.5mgmL-1). | LIU Chenguang Desai Kashappa Goud H. CHEN Xiguang Park Hyun-Jin | 2005 | Journal of Ocean University of China2005，4，3： | 6 |
| 7 | Design and Synthesis of Cu@CuS Yolk–Shell Structures with Enhanced Photocatalytic Activity显示文摘Non-spherical Cu@Cu S yolk–shell structures are successfully obtained using Cu_2 O cube templates in a process combining rapid surface sulfidation followed by disproportionation of the Cu_2 O core upon treatment with a hydrochloric acid solution. By employing the above method,Cu@Cu S yolk–shell structures with different morphologies,including octahedral, truncated octahedral, and cuboctahedral shapes, can be synthesized. The void space within the hollow structures provides a unique confined space, where the metallic copper present in the core of a shell can be protected from agglomeration and oxidation. Furthermore,the presence of metal copper in these hollow structurescontributes to improvement in the photocatalytic properties of these materials. The application of these Cu@Cu S structures indeed shows clearly improved photocatalytic performance. | Qiuyan Li Fan Wang Linqiang Sun Zhe Jiang Tingting Ye Meng Chen Qiang Bai Chao Wang Xiguang Han | 2017 | Nano-Micro Letters2017，9，3： | 6 |
| 8 | Symmetry energy dependence of the pygmy and giant dipole resonances in an isospin dependent quantum molecular dynamics model显示文摘Isospin-dependent Quantum Molecular Dynamics model (IQMD) has been applied to investigate the Pygmy Dipole Resonance (PDR) and Giant Dipole Resonance (GDR) in Ni isotopes by Coulomb excitation. By Gaussian fitting to the photon emission spectra, the peak energies and strengths of PDR and GDR are extracted. Their sensitivities to impact parameter, incident energy and the symmetry energy are discussed. By the comparison of energy-weighted sum rule (EWSR) with the data and other calculations for 68 Ni, the parameters of density-dependence of symmetry energy in the IQMD are constrained. In addition, the N/Z dependence of PDR and GDR parameters of Ni isotopes are investigated, and the results that the EWSR increases linearly with the N/Z are obtained. | TAO Cheng MA Yugang ZHANG Guoqiang CAO Xiguang FANG Deqing WANG Hongwei | 2013 | Nuclear Science and Techniques2013，24，3： | 5 |
| 9 | Tensile and fracture properties of Ti-62A alloy plate with different microstructures显示文摘Ti-62A alloy plates with three different types of microstructure, fully equiaxed, bimodal, and Widmanst tten, were obtained by various heat treatments to investigate the effects of microstructure on the tensile and fracture properties at room temperature. The results reveal that Widmanst tten microstructure exhibits good damage tolerance behavior considering strength, fracture toughness, and fatigue crack growth behavior, while the bimodal microstructure shows good comprehensive properties considering the plasticity synthetically. Optical microscopy (OM) and scanning electron microscopy (SEM) microstructure analyses on fracture and fatigue crack path demonstrate that the dependence of mechanical properties and fatigue crack growth behavior on microstructural feature are attributed to the α lamellae width and the α colony size. | LIU Rui HUI Songxiao YE Wenjun YU Yang FU Yanyan SONG Xiaoyun DENG Xiguang | 2012 | Rare Metals2012，31，5： | 5 |
| 10 | Reverse immune suppressive microenvironment in tumor draining lymph nodes to enhance anti-PD1 immunotherapy via nanovaccine complexed microneedle显示文摘The maturation of dendritic cells(DCs)and infiltration effector T cells in tumor-draining lymph node(tdLN)and tumor tissue are crucial for immunotherapy.Despite constructive progresses have been made with anti-programmed death-1(anti-PD1)checkpoint blockade for immunotherapy,the efficacy of PD1/PD-L1 therapy deserves to be improved.Here,we constructed a novel transfersomes based nanovaccine complexed microneedles to enhance anti-PD1 immunotherapy via transdermal immunization for skin tumor therapy.Transfersomes were functionalized with DCs targeting moietyαCD40,co-encapsulated with antigens and adjuvant poly I:C.Moreover,transdermal administration promoted accumulation in tumor-draining lymph nodes(tdLN),which could facilitate cellular uptake,activate DCs maturation and enhance Th1 immune responses.Using a mouse melanoma model,combined therapy of such nanovaccine complexed microneedles with pembrolizumab(αPD1)was able to enhance cytotoxic T lymphocytes activation,promote infiltration and reduce regulatory T cells frequency in tdLN and tumor tissues,which achieved reversion of the immunosuppressive microenvironment into immune activation.This study highlighted the potential of transfersomes based nanovaccines complexed microneedles as an attractive platform for tumor immunotherapy. | Zhongzheng Zhou Jianhui Pang Xuanjin Wu Wei Wu Xiguang Chen Ming Kong | 2020 | Nano Research2020，13，6： | 5 |
| 11 | Effect of UV-B Radiation on Ingesting and Nutritional Selecting Behavior of Rotifer Brachionus urceus显示文摘Effect of UV-B radiation on ingesting and nutritional selecting behavior of the roifer Brachionus urceus on 5 species of micro-algae were studied under controlled laboratory conditions. Results showed that enhanced UV-B radiation significantly inhibited ingesting of the rotifer B. urceus when it was fed with 5 species of micro-algae (p<0.05). The ingesting selectivity rate varied with the UV-B radiation enhancement when it was fed with 5 species micro-algal mixture. Results indicated that the enhanced UV-B radiation could affect ingesting and nutritional selectivity of B. urceus. | FENG Lei TANG Xuexi WANG You XIAO Hiu MENG Xianghong CHEN Xiguang | 2007 | Wuhan University Journal of Natural Sciences2007，12，2： | 4 |
| 12 | Energy-Efficient Cooperative Strategy in RF Energy Harvesting Cognitive Radio Network显示文摘Energy-efficient cooperative spectrum sharing has become a new trend based on financial and environmental considerations. We focus on a novel energy-efficient cooperative strategy in a Radio frequency(RF) energy harvesting cognitive radio network, where the Secondary user(SU) provides energy supply and relaying assist for the Primary user(PU) in exchange for the transmission opportunities. On the basis of energy and information cooperation, an Energy efficiency(EE)maximization non-convex problem for SU is formulated under the PU's Quality of service(QoS) requirement and energy-causality constraint. With the aid of Dinkebalch's method and convex optimization technique, a joint time and power allocation scheme is proposed. Numerical results show that the proposed scheme achieves higher SU's EE and better PU's QoS guarantee compared to the scheme in which the SU only provides energy for the PU's transmission. | YAN Feiyu ZHAO Jihong QU Hua XU Xiguang | 2019 | Chinese Journal of Electronics2019，28，3： | 4 |
| 13 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 14 | Effect of UV-B radiation on the feeding behavior of the rotifer Brachionus plicatilis显示文摘Effect of UV-B radiation on the feeding behaviour of marine zooplankton is important to assessing the health harm of marine ecosystem due to the gradually enhanced UV-B radiation in air. However, there are a few studies on this topic. The feeding behavior of the rotifer, Brachionus plicatilis, under the treatment of UV-B radiation on five species of microalgae, i.e., Chlorella sp., Tetraselmis chuii, Isochrysis galbana Park 8701, Chaetoceros muelleri Lermumerman, and Nitzschia clostertum, was studied. The results showed that the filtering and feeding rates of the rotifer decreased significantly with the dose increase of UV-B radiation when fed with five species of microalgae respectively (P<0.05) which indicates UV-B radiation inhibits the feeding activities of the rotifer on microalage. The mixed culture experiments shows the rotifer preferred to feed Chlorella sp., then C. muelleri,I. galbana, N. clostertum and T. chuii in turn if without UV-B radiation. Under the highest dose of UV-B radiation treatment (2.70 kJ/m2), the rotifer preferred to feed C. muelleri, then Chlorella sp., N. clostertum, I. galbana and T. chuii in turn. Chlorella sp., I. galbana and C. muelleri became the more favorite foods of the rotifer while T. chuii and N. clostertum became less favorite foods. The change of feeding rate and feeding selectivity of zooplankton driven by the enhanced UV-B radiation will lead to the change in the structure of phytoplankton community. | FENG Lei LI Xin WANG Jinhe HAN Honglei TANG Xuexi CHEN Xiguang | 2007 | Acta Oceanologica Sinica2007，26，4： | 4 |
| 15 | 简易定向锥颅脑内血肿碎吸术及其因型综合施治高血压脑出血显示文摘本文以简易定向锥颅脑内血肿碎吸术(简称“碎吸术”)为主的因型施治方案治疗了1157例高血压脑出血病人。本资料对1157例病人未进行选择,根据病人的不同临床分期,出血部位及量、年龄、有无合并症等实际情况,治疗方法选择一种或一种以上综合。在1157例中,临床分期为Ⅲ~Ⅴ期的病人占74.4%;年龄>60岁者占33.9%,破入脑室者占20.2%。治疗结果:死亡率为22.5%。本文介绍了这一新的治疗方法和方案的设计,并从死亡率、手术适应症及再出血等方面,结合有关文献进行了讨论。 | Chen Xiguang Department of Surgery,Second Affiliated Hospital,Dalian Medical College | 1993 | 大连医学院学报1993，15，1： | 3 |
| 16 | NUMERICAL STUDY ON THE UNSTEADY INTERACTION FLOW IN A CENTRIFUGAL COMPRESSOR STAGE显示文摘Numerical simulation on the unsteady flow in a centrifugal compressor is performed, and compared with the experimental data. The influence of the impeller-diffuser interaction on the flowfields is discussed, and the reasons for the losses are also explored. Results show that qualitative and quite fair quantitative agreements are achieved between the predicted and measured flowfields. The influence of the impeller wake on the convexity surface of diffuser is great. The potential repercussion of the diffuser on the suction surface of the impeller is much larger than on the pressure surface. Effect of the unsteady interaction is strongest in the radial gap. The unsteady flow itself may compensate for the loss generated in stage, and the stage efficiency is inversely proportional to the entropy production. | ZhouLi XiGuang GaoLimin WangShangjin | 2004 | Chinese Journal of Mechanical Engineering2004，17，4： | 3 |
| 17 | Isolation of fucoxanthin from Sargassum thunbergii and preparation of microcapsules based on palm stearin solid lipid core显示文摘 | Xuanxuan WANG Hongyan LI Fangqin WANG Guixue XIA Hongjun LIU Xiaojie CHENG Ming KONG Ya LIU Chao FENG Xiguang CHEN Ying WANG | 2017 | Frontiers of Materials Science2017，11，1： | 3 |
| 18 | Preparations,Characterizations and Applications of Chitosan-based Nanoparticles显示文摘Chitosan is a natural polysaccharide prepared by the N-deacetylation of chitin. In this paper we have reviewed the methods of preparation of chitosan-based nanoparticles and their pharmaceutical applications. There are five methods of their prepa-rations:emulsion cross-linking,emulsion-droplet coalescence,ionic gelation,reverse micellar method and chemically modified chi-tosan method. Chitosan nanoparticles are used as carriers for low molecular weight drug,vaccines and DNA. Releasing characteris-tics,biodistribution and applications are also summarized. | LIU Chenguang TAN Yulong LIU Chengsheng CHEN Xiguang YU Lejun | 2007 | Journal of Ocean University of China2007，6，3： | 3 |
| 19 | Anaerobic digestion of food wastes for biogas production显示文摘Five types of food wastes were investigated as feedstock for a potential centralized anaerobic digester system in the area of Sacramento,California to produce biogas energy.The wastes were from a soup processing plant,a cafeteria,a commercial kitchen,a fish farm,and grease trap collection service.Digestibilities of the food wastes,individually and in mixtures,were conducted at mesophilic(35℃)and thermophilic(50℃)temperatures and at two food to microorganism ratios(F/M)of 0.5 and 1.0,for 28 days.A continuously fed mesophilic single-stage anaerobic digester was evaluated using a mixture of the five food wastes at organic loading rates of 0.5 to 1.0 g VS/L/d.In the batch digestion tests,fish and grease trap wastes required longer time to complete the digestion and had higher biogas yields than the other wastes.The continuously-fed digester required the addition of sodium hydroxide to maintain pH at proper levels in the digester.Alkalinity of about 2,500 mg CaCO3/L and pH above 7 was maintained by adding 0.2 g NaOH/g VS.The results of this study indicated that it was necessary to use the chemicals,such as NaOH,to control the pH of the single-stage anaerobic digester treating the food waste.For commercial applications,the cost of chemicals and proper management of additional salts in the digester effluent need to be carefully considered. | Xiguang Chen Rowena TRomano Ruihong Zhang | 2010 | International Journal of Agricultural and Biological Engineering2010，3，4： | 3 |
| 20 | Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing显示文摘 | Guohui SUN Chao FENG Ming KONG Xiaojie CHENG Jiaojiao BING Guixue XIA Zixian BAO Hyunjin PARK Xiguang CHEN | 2015 | Frontiers of Materials Science2015，9，3： | 2 |
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