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| 1 | Androgen receptor: structure, role in prostate cancer and drug discovery显示文摘Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade by drugs that prevent the production of androgens and/or block the action of the AR inhibits prostate cancer growth. However, resistance to these drugs often occurs after 2-3 years as the patients develop castration-resistant prostate cancer (CRPC). In CRPC, a functional AR remains a key regulator. Early studies focused on the functional domains of the AR and its crucial role in the pathology. The elucidation of the structures of the AR DNA binding domain (DBD) and ligand binding domain (LBD) provides a new framework for understanding the functions of this receptor and leads to the development of rational drug design for the treatment of prostate cancer. An overview of androgen receptor structure and activity, its actions in prostate cancer, and how structural information and high-throughput screening have been or can be used for drug discovery are provided herein. | MH Eileen TAN Jun LI H Eric XU Karsten MELCHER Eu-leong YONG | 2015 | Acta Pharmacologica Sinica2015，36，1： | 39 |
| 2 | Qingyi decoction protects against myocardial injuries induced by severe acute pancreatitis显示文摘BACKGROUND We studied the protective effects of Qingyi decoction(QYD)(a Traditional Chinese Medicine)against severe acute pancreatitis(SAP)-induced myocardial infarction(MI).AIM To study the function and mechanism of QYD in the treatment of myocardial injuries induced by SAP.METHODS Ultrasonic cardiography,hematoxylin and eosin staining,immunohistochemistry,qRT-PCR,western blot,enzyme-linked immunosorbent assays,and apoptosis staining techniques were used to determine the effects of QYD following SAP-induced MI in Sprague-Dawley rats.RESULTS Our SAP model showed severe myocardial histological abnormalities and marked differences in the symptoms,mortality rate,and ultrasonic cardiography outputs among the different groups compared to the control.The expression of serum cytokines[interleukin(IL)-1?,IL-6,IL-8,IL-12,amyloidβ,and tumor necrosis factor-α]were significantly higher in the SAP versus QYD treated group(P<0.05 for all).STIM1 and Orai1 expression in myocardial tissue extracts were significantly decreased post QYD gavage(P<0.001).There was no significant histological difference between the 2-aminoethyl diphenylborinate inhibitor and QYD groups.The SAP group had a significantly higher apoptosis index score compared to the QYD group(P<0.001).CONCLUSION QYD conferred cardio-protection against SAP-induced MI by regulating myocardial-associated protein expression(STIM1 and Orai1). | Lei Li Yong-Qi Li Zhong-Wei Sun Cai-Ming Xu Jun Wu Ge-Liang Liu Ahmed MH Bakheet Hai-Long Chen | 2020 | World Journal of Gastroenterology2020，26，12： | 17 |
| 3 | Collecting aerosol in airflow with a magnetically stabilized fluidized bed显示文摘A magnetically stabilized fluidized bed (MSB) is a highly efficient filter that takes the advantage of both fluidized beds and fixed beds. This paper presents the research to collect aerosol in airflow with a MSB. The filtering model of MSB is established with its parameters including magnetic field intensity, gas superficial velocity, average grain size, and bed height on the collection efficiency of MSB. The model is verified by experiments. | Gui, KT Zhang, H Shi, MH Xu, YQ | 2001 | Journal of Environmental Sciences2001，13，4： | 3 |
| 4 | Immunological adaptive response induced by low dose X-rays显示文摘 | Ju Guizhi Su Xu Song Chunhua Liu Shuzheng (MH Radiobiology Research Unit Norman Bethune University of Medical Sciences Changchun 130021)\ \ | 1999 | 白求恩医科大学学报1999，25，5： | 2 |
| 5 | Structural determinants of ligand binding selectivity between the peroxisome proliferator activated receptors显示文摘 | XU HE LAMBERT MH MONTANA VG | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 6 | Absence of the adenosine A2A re- ceptor confers pulmonary arterial hypertension and increased pub monary vascular remodeling in mice显示文摘 | Xu MH Gong YS Su MS etal | 2011 | J Vase Res2011，48，2： | 1 |
| 7 | Electron beam induced degradation of clopyralid in aqueous solutions显示文摘 | Xu G Bu 7 Wu MH | 2011 | Radioanal Nucl Chem2011，288，3： | 1 |
| 8 | MALATl promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9显示文摘 | Yang MH Hu ZY Xu C | 2015 | Biochim Biophys Acta2015，1852，1： | 1 |
| 9 | High potential to reverse the inhibition of myeloperoxidase by ceruloplasmin of anti-myeloper- oxidase autoantibodies of IgG3 subclass显示文摘 | Xu PC Chen M Zhao MH | 2012 | Autoimmunity2012，45，： | 1 |
| 10 | HIV prevalence and associated factors among foreign brides from Burma in Yunnan province,China 显示文摘 | Xu Y Fu LR Jia MH | 2014 | PLOS One2014，9，11： | 1 |
| 11 | Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage显示文摘 | Wang J Xu X Elliott MH | | 0，，09： | 1 |
| 12 | Ab-sence of the adenosine A2A receptor confers pulmonary arterial hy-pertension and increased pulmonary vascular remodeling in mice显示文摘 | Xu MH Gong YS Su MS Dai ZY Dai SS Bao SZ | 2011 | J Vasc Res2011，48，2： | 1 |
| 13 | Silencing of cyclooxygenase-2 inhibits the growth,invasion and migration of ovarian cancer cells显示文摘 | Lin Y Cui MH Xu TM | 2014 | Molecular Medicine Reports2014，9，6： | 1 |
| 14 | Evaluation of a PCR/ESI-MS platform to identify respiratory viruses from nasopharyngeal aspirates 显示文摘 | Lin Y Fu YF Xu MH | 2015 | J Med Virol2015，87，11： | 1 |
| 15 | The histogenesis of giant cell tumour of bone: a model of interaction between neoplastic cells and osteoclasts 显示文摘 | Zheng MH Robbins P Xu J | 2001 | Histol Histopathol2001，16，4： | 1 |
| 16 | Gene expression of vascular endothdlial growth factor in giant cell tumor of bone显示文摘 | Zheng MH Xu J Robbins P | 2000 | Hum Pathol2000，31，： | 1 |
| 17 | Gene expression of vascular endothelial growth factor in giant cell tumors of bone显示文摘 | Zheng MH Xu J Robbins P | 2000 | Hum Pathol2000，31，7： | 1 |
| 18 | Aberrantly glycoaylated serum IgAl are closelyassociated with pathological phenotypes of IgA nephropathy显示文摘 | Zhao MH | 2005 | Kidney Int2005，68，： | 1 |
| 19 | D(1)/D(2) receptor-targeting L-stepholidine, an active ingredient of the Chinese herb Stephonia, induces nonrapid eye movement sleep in mice显示文摘 | Qiu MH Qu WM Xu XH | 2009 | Pharmacol Biochem Behav2009，94，1： | 1 |
| 20 | Molecular recognition of fatty acids by peroxisome proliferator activated receptors 显示文摘 | Xu HE Lambert MH Montana VG | 1999 | Mol Cell1999，3，5： | 1 |
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