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| 1 | Sintering of WC-Co powder with nanocrystalline WC by spark plasma sintering显示文摘A 92WC-8Co powder mixture with 33 nm WC grains was prepared by strengthening ball milling and was then sintered by spark plasma sintering (SPS) at 1000-1200°C for 5-18 min under 10-25 kN, respectively. Movement of the posi-tion of low punch shown shrinkage of the sintered body began above 800°C. The shrinkage slowly rose as the temperature rose from 800 to 1000°C and then quickly rose at above 1000°C and then gradually rose at above 1150°C. The densities of the samples increased with an increase in sintering temperature, rapidly below 1100°C, and then gradually above 1100°C. WC grains grow gradually with increasing sintering temperature. The powder was sintered to near full density at 1100°C for 5 min under 10 kN. The best result of the sample with 275 nm WC grains and no pores was obtained at 1150°C under 10 kN for 5 min. The research found the graphite die had a function of carburization, which could compensate the sintered body for the lack of carbon, and had the normal microstructure. | WANG Xingqing XIE Yingfang GUO Hailiang O.Van der Biest J.Vleugels | 2006 | Rare Metals2006，25，3： | 7 |
| 2 | The LRXs-RALFs-FER module controls plant growth and salt stress responses by modulating multiple plant hormones显示文摘Salt stress is a major environmental factor limiting plant growth and productivity.We recently discovered an important new salt tolerance pathway,where the cell wall leucine-rich repeat extensins LRX3/4/5,the RAPID ALKALINIZATION FACTOR(RALF)peptides RALF22/23 and receptor-like kinase FERONIA(FER)function as a module to simultaneously regulate plant growth and salt stress tolerance.However,the intracellular signaling pathways that are regulated by the extracellular LRX3/4/5-RALF22/23-FER module to coordinate growth,cell wall integrity and salt stress responses are still unknown.Here,we report that the LRX3/4/5-RALF22/23-FER module negatively regulates the levels of jasmonic acid(JA),salicylic acid(SA)and abscisic acid(ABA).Blocking JA pathway rescues the dwarf phenotype of the lrx345 and fer-4mutants,while disruption of ABA biosynthesis suppresses the salt-hypersensitivity of these mutants.Many salt stress-responsive genes display abnormal expression patterns in the lrx345 and fer-4 mutants,as well as in the wild type plants treated with epigallocatechin gallate(EGCG),an inhibitor of pectin methylesterases,suggesting cell wall integrity as a critical factor that determines the expression pattern of stress-responsive genes.Production of reactive oxygen species(ROS)is constitutively increased in the lrx345 and fer-4mutants,and inhibition of ROS accumulation suppresses the salt-hypersensitivity of these mutants.Together,our work provides strong evidence that the LRX3/4/5-RALF22/23-FER module controls plant growth and salt stress responses by regulating hormonal homeostasis and ROS accumulation. | Chunzhao Zhao Wei Jiang Omar Zayed Xin Liu Kai Tang Wenfeng Nie Yali Li Shaojun Xie Yuan Li Tiandan Long Linlin Liu Yingfang Zhu Yang Zhao Jian-Kang Zhu | 2021 | National Science Review2021，8，1： | 3 |
| 3 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 4 | TOR激酶和ABA受体的相互调控平衡植物生长和胁迫应答显示文摘文章简介由于无法通过移动有效的逃避胁迫,植物必须精确地平衡生长发育和胁迫应答,以适应不断变化的环境。在干旱等胁迫来临时,植物需要抑制生长发育并激活胁迫应答过程以维持生存;在胁迫条件解除后,植物又需要及时解除胁迫反应并恢复生长。 | Pengcheng Wang Yang Zhao Zhongpeng Li Chuan-Chih Hsu Xue Liu Liwen Fu Yueh-Ju Hou Yanyan Du Shaojun Xie Chunguang Zhang Jinghui Gao Minjie Cao Xiaosan Huang Yingfang Zhu Kai Tang Xingang Wang W.Andy Tao 熊延 朱健康 | 2019 | 科学新闻2019，0，2： | 0 |
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