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| 1 | Exosomes containing miR-21 transfer the characteristic of cisplatin resistance by targeting PTEN and PDCD4 in oral squamous cell carcinoma显示文摘 | Tao Liu Gang Chen Dawei Sun Minghui Lei Yongqiang Li Changming Zhou Xiaodong Li Wei Xue Hong Wang Chunjun Liu Jiang Xu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，9： | 22 |
| 2 | H. pylori Escape Host Immunoreaction Through Inhibiting ILK Expression by VacA显示文摘Helicobacter pylori (H。pylori ) 尽管有精力旺盛的有免疫力的回答,固执地开拓殖民地于胃的 mucosa。Vacuolating 细胞毒素由 H 藏匿了。pylori 结果是有势力 immunomodulatory 毒素,而是包含的信号 transduction 小径没在巨噬细胞被学习。我们在这研究观察了那 vacA 缺乏的 H。pylori 导致了连接 integrin 的 kinase (同类) 和 endothelial 的显著地更高的表示氮的氧 synthase (eNOS ) ,并且显著地在 monocyte/macrophage-like U937 房间的反应的氧种类(ROS ) 的更多的生产,同样与 isogenic vacA+H 相比。pylori。在 U937 房间 overexpressing 同类的 eNOS mRNA 的表示显著地与空向量与那些 transfected 相比被增加。因此, vacA 缺乏的 H。pylori 出现到 upregulate 同类表示,调制 eNOS 并且作为结果的表示,刺激 ROS 的生产。,帮助 H 是 VacA 由禁止同类表示阻止如此的进程。pylori 逃跑主人免疫反应。这机制解释,至少部分地, H 的坚持的感染。在胃的 pylori。 | Jianping Yuan Ping Li Jing Tao Xiaodong Shi Baoyu Hu Huabiao Chen Xiaokui Guo | 2009 | Cellular & Molecular Immunology2009，6，3： | 12 |
| 3 | Immunotherapeutical Potential of Mycobacterium Vaccae on M. Tuberculosis Infection in Mice显示文摘Tuberculosis remains the worldwide infectious disease. To identify the therapeutic potential of M. vaccae in treating tuberculosis,M. vaccae was injected into Mycobacterium tuberculosis(M. tuberculosis) infected mice. The optimal dose of M. vaccae(22.5 μg/mouse) treated mice showed lower pathological change index,spleen weight index,lung weight index and vital M. tuberculosis count than those of the untreated group. Treatment with M. vaccae enhanced the percentages of CD3+ and CD4+ T cells,IFN-γ+CD4+ T cells,innate immune cells including NK cells,NK1.1+ T cells and γδ T cells,and reduced the percentage of IL-4+CD4+ T cells. Therefore,M. vaccae could protect the mice from M. tuberculosis infection and improved mouse innate and adaptive cell-mediated immunity,suggesting that M. vaccae is a potential immunotherapeutic agent in pulmonary tuberculosis. | Lijun Xu Yanyan Wang Xiaodong Zheng Xiangdong Gui Lifeng Tao Haiming Wei | 2009 | Cellular & Molecular Immunology2009，6，1： | 11 |
| 4 | Characterization and allergic role of IL-33-induced neutrophil polarization显示文摘Neutrophils are involved in the pathogenesis of allergy.However,the contribution of the different functionally polarized neutrophils in allergy needs to be clarified.We sought to define the characteristics of interleukin(IL)-33-induced neutrophils and the involvement of this subset of polarized neutrophils in allergic pathogenesis.Freshly isolated neutrophils were treated with different cytokines and the cytokine expression levels were detected by realtime PCR.The gene expression profile of IL-33-induced neutrophils was determined by microarray assay.Adoptive transfer assay was used to investigate the function of IL-33-induced neutrophils in an ovalbumin(OVA)-induced allergic asthma model.IL-33-treated neutrophils selectively produced IL-4,IL-5,IL-9 and IL-13(referred as to N(IL-33)cells)and displayed a distinctive gene expression profile in sharp contrast to resting and lipopolysaccharide(LPS)-treated neutrophils.IL-33-induced neutrophils expressed high Levels of IL-1R2 on cell surface,whereas resting and LPS-treated neutrophils did not,indicating IL-1R2 might be used as a biomarker for N(IL-33)cells.Importantly,N(IL-33)neutrophils exist in the lungs of OVA-induced allergic asthma mice.Adoptive transfer of N(IL-33)neutrophils significantly promotes the severity of the lung pathogenesis in this model.IL-33 induces neutrophil polarization through c-Jun N-terminal kinase-and nuclear factor-κB-dependent pathways.A previously unappreciated neutrophil polarization driven by IL-33 with unique cell surface markers and cytokine/chemokineproducing gene profile was defined.The newly identified N(IL-33)subpopulation may have significant contribution to IL-33-related pathogenesis. | Bo Sun Linnan Zhu Yaling Tao Hai-Xi Sun Yang Li Peng Wang Yuzhu Hou Yang Zhao Xiaodong Zhang Lianfeng Zhang Ning Na Yong Zhao | 2018 | Cellular & Molecular Immunology2018，15，8： | 9 |
| 5 | Intravitreal bevacizumab with or without triamcinolone acetonide for diabetic macular edema: a meta-analysis of randomized controlled trials显示文摘 | Liu Xiangdong Zhou Xiaodong Wang Zhi Li Tao Jiang Bo | 2014 | Chinese Medical Journal2014，，19： | 7 |
| 6 | SDN Based Next Generation Mobile Network With Service Slicing and Trials显示文摘Software-Defined Network(SDN)empowers the evolution of Internet with the OpenFlow,Network Virtualization and Service Slicing strategies.With the fast increasing requirements of Mobile Internet services,the Internet and Mobile Networks go to the convergence.Mobile Networks can also get benefits from the SDN evolution to fulfill the Sth Generation(5G) capacity booming.The article implements SDN into Frameless Network Architecture(FNA) for5G Mobile Network evolution with proposed Mobile-oriented OpenFlow Protocol(MOFP).The Control Plane/User Plane(CP/UP)separation and adaptation strategy is proposed to support the User-Centric scenario in FNA.The traditional Base Station is separated with Central Processing Entity(CPE) and Antenna Element(AE) to perform the OpenFlow and Network Virtualization.The AEs are released as new resources for serving users.The mobile-oriented Service Slicing with different Quality of Service(QoS) classification is proposed and Resource Pooling based Virtualized Radio Resource Management(VRRM) is optimized for the Service Slicing strategy with resource-limited feature in Mobile Networks.The capacity gains are provided to show the merits of SDN based FNA.And the MiniNet based Trial Network with Service Slicing is implemented with experimental results. | XU Xiaodong ZHANG Huixin DAI Xun HOU Yanzhao TAO Xiaofeng ZHANG Ping | 2014 | China Communications2014，11，2： | 7 |
| 7 | Holistic Service-Based Architecture for Space-Air-Ground Integrated Network for 5G-Advanced and Beyond显示文摘The Service-based Architecture(SBA) is one of the key innovations of 5G architecture that leverage modularized, self-contained and independent services to provide flexible and cloud-native 5G network. In this paper, SBA for Space-Air-Ground Integrated Network(SAGIN) is investigated to enable the 5G integration deployment. This paper proposes a novel Holistic Service-based Architecture(H-SBA)for SAGIN of 5G-Advanced and beyond, i.e., 6G. The H-SBA introduces the concept of end-to-end servicebased architecture design. The 'Network Function Service', introduced in 5G SBA, is extended from Control Plane to User Plane, from core network to access network. Based on H-SBA, the new generation of protocol design is proposed, which proposes to use IETF QUIC and SRv6 to substitute 5G HTTP/2.0 and GTP-U. Testing results show that new protocols can achieve low latency and high throughput, making them promising candidate for H-SBA. | Xiaoyun Wang Tao Sun Xiaodong Duan Dan Wang Yongjing Li Ming Zhao Zhigang Tian | 2022 | China Communications2022，19，1： | 6 |
| 8 | Chemoselective hydrogenolysis of tetrahydrofurfuryl alcohol to 1,5-pentanediol over Ir-MoO_x/SiO_2 catalyst显示文摘In this work, MoOx promoted Ir/SiO2 catalysts were prepared and used for the selective hydrogenolysis of tetrahydrofurfuryl alcohol(THFA)to 1,5-pentanediol in a continuous flow reactor. The effects of different noble metals(Ir, Pt, Pd, Ru, Rh), supports and Ir contents were screened.Among the investigated catalysts, 4 wt%Ir-MoOx/SiO2 with a Mo/Ir atomic ratio of 0.13 exhibited the best catalytic performance. The synergy between Ir particles and the partially reduced isolated MoOx species attached on them is essential for the excellent catalytic performance of Ir-MoOx/SiO2. The catalyst exhibited a better hydrogenolysis efficiency of THFA with the selectivity of 1,5-pentanediol of 65%–74% at a conversion of THFA of 70%–75% when the initial THFA concentration is ranging from 20 wt% and 40 wt%. And higher system pressure was also in favor of the conversion of THFA. During a stability test, the conversion of THFA and 1,5-pentanediol yield over Ir-MoOx/SiO2 decreased with reaction time, which can be explained by the leaching of Mo species during the reaction. | Zhiqiang Wang Boonrat Pholjaroen Mengxia Li Wenjun Dong Ning Li Aiqin Wang Xiaodong Wang Yu Cong Tao Zhang | 2014 | Journal of Energy Chemistry2014，23，4： | 6 |
| 9 | Multicell power allocation method based on game theory for inter-cell interference coordination显示文摘As a new technology, coordinated multipoint (CoMP) transmission is included in LTE-Advanced study item. Moreover, the network architecture in LTE-Advanced system is modified to take into account coordinated transmission. Under this background, a novel power allocation game model is established to mitigate inter-cell interference with cellular coordination. In the light of cellular cooperation relationship and centralized control in eNodeB, the power allocation in each served antenna unit aims to make signal to interference plus noise ratio (SINR) balanced among inter-cells. Through the proposed power allocation game algorithm, the users' SINR can reach the Nash equilibrium, making it feasible to reduce the co-frequency interference by decreasing the transmitted power. Numerical results show that the proposed power allocation algorithm improves the throughput both in cell-center and cell-edge. Moreover, the blocking rate in cell-edge is reduced too. | ZHANG Hui XU XiaoDong LI JingYa TAO XiaoFeng ZHANG Ping SVENSSON Tommy BOTELLA Carmen | 2009 | Science in China(Series F)2009，52，12： | 5 |
| 10 | Resource pooling for frameless network architecture with adaptive resource allocation显示文摘The system capacity for future mobile communication needs to be increased to fulfill the emerging requirements of mobile services and innumerable applications. The cellular topology has for long been regarded as the most promising way to provide the required increase in capacity. However with the emerging densification of cell deployments, the traditional cellular structure limits the efficiency of the resource, and the coordination between different types of base stations is more complicated and entails heavy cost. Consequently, this study proposes frameless network architecture (FNA) to release the cell boundaries, enabling the topology needed to implement the FNA resource allocation strategy. This strategy is based on resource pooling incorporating a new resource dimension-antenna/antenna array. Within this architecture, an adaptive resource allocation method based on genetic algorithm is proposed to find the optimal solution for the multi-dimensional resource allocation problem. Maximum throughput and proportional fair resource allocation criteria are considered. The simulation results show that the proposed architecture and resource allocation method can achieve performance gains for both criteria with a relatively low complexity compared to existing schemes. | XU XiaoDong WANG Da TAO XiaoFeng SVENSSON Tommy | 2013 | Science China(Information Sciences)2013，56，2： | 5 |
| 11 | Robust detector for range-spread targets in non-Gaussian background显示文摘Based on the target scatterer density,the range-spread target detection of high-resolution radar is addressed in additive non-Gaussian clutter,which is modeled as a spherically invariant random vector.Firstly,for sparse scatterer density,the detection of target scatterer in each range cell is derived,and then an M/K detector is proposed to detect the whole range-spread target.Secondly,an integrating detector is devised to detect a range-spread target with dense scatterer density.Finally,to make the best of the advantages of M/K detector and integrating detector,a robust detector based on scatterer density(DBSD) is designed,which can reduce the probable collapsing loss or quantization error effectively.Moreover,the density decision factor of DBSD is also determined.The formula of the false alarm probability is derived for DBSD.It is proved that the DBSD ensures a constant false alarm rate property.Furthermore,the computational results indicate that the DBSD is robust to different clutter one-lag correlations and target scatterer densities.It is also shown that the DBSD outperforms the existing scatterer-density-dependent detector. | Tao Jian You He Feng Su Dianfa Ping Xiaodong Huang | 2012 | Journal of Systems Engineering and Electronics2012，23，3： | 5 |
| 12 | Synthesis, Characterization, and Catalytic Application of Highly Ordered Mesoporous Alumina-Carbon Nanocomposites显示文摘高度订的 mesoporous 碳氧化铝 nanocomposites (OMCA ) 被热分解在高温度跟随的一个多部件合作集会方法第一次综合了。在这合成, resol 酚甲醛树脂(PF 树脂) 和氧化铝大音阶的第五音分别地作为模板被用作碳和氧化铝先锋和 triblock 共聚物 Pluronic F127。N2 吸附大小, X 光检查衍射,和传播电子显微镜学揭示了那,随在从 11 ~ 48 wt.% 的 nanocomposite 的氧化铝内容的增加,当订的 mesoporous 结构被保留时,毛孔尺寸从 2.9 ~ 5.0 nm 增加了。进一步增加氧化铝内容到 53 wt.% 导致了像虫孔的结构,尽管毛孔尺寸分发仍然是狭窄的。nanocomposite 墙由连续的碳和非结晶的氧化铝组成,它允许订的 mesostructure 被 HF 在空中由锻烧蚀刻或碳的移动很好甚至在氧化铝的移动以后保存。OMCA nanocomposites 低于 1000 展出了好 | Jinming Xu Aiqin Wang Xiaodong Wang Dangsheng Su Tao Zhang | 2011 | Nano Research2011，4，1： | 5 |
| 13 | Surface morphology and electronic structure in stoichiometric superconductor CaKFe_(4)As_(4) robed by scanning tunneling microscopy/spectroscopy显示文摘CaKFe_(4)As_(4) is a new-type superconductor with a relatively high transition temperature of 35 K among stoichiometric iron-based superconductors. Based on scanning tunneling microscopy/spectroscopy, the surface morphology and electronic structure of CaKFe_(4)As_(4) single crystal were systematically investigated. The cleaved CaKFe_(4)As_(4) showed various morphologies, such as atomically resolved 1×1, 1×2, and √2×√2 lattices. By analyzing the geometrical correlations of these morphologies, the 1×1 and 1×2 lattices were identified as the original and reconstructed As layers, respectively, whereas the √2×√2 lattice was distinguished as the reconstructed alkaline-earth-metal or alkali-metal layer. The superconducting energy gap of 7.3 me V and bosonic mode of 12.7 me V were resolved in the scanning tunneling spectra. In addition, the superconducting energy gaps measured on different terminations were identical and consistent with the values obtained by bulk-sensitive techniques, indicating that the electronic structures of CaKFe_(4)As_(4) were insensitive to the surface reconstructions. Our study clarifies the relationships between complex surface reconstructions and surface terminations and preliminarily presents that there is no obvious effect of surface reconstructions on electronic states. | Xiaodong Yu Zhongxu Wei Zhanyi Zhao Tao Xie Chang Liu Ge He Qihong Chen Lei Shan Huiqian Luo Qing Huan Jie Yuan Kui Jin | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 5 |
| 14 | Joint Allocation of Wireless Resource and Computing Capability in MEC-Enabled Vehicular Network显示文摘In MEC-enabled vehicular network with limited wireless resource and computation resource,stringent delay and high reliability requirements are challenging issues.In order to reduce the total delay in the network as well as ensure the reliability of Vehicular UE(VUE),a Joint Allocation of Wireless resource and MEC Computing resource(JAWC)algorithm is proposed.The JAWC algorithm includes two steps:V2X links clustering and MEC computation resource scheduling.In the V2X links clustering,a Spectral Radius based Interference Cancellation scheme(SR-IC)is proposed to obtain the optimal resource allocation matrix.By converting the calculation of SINR into the calculation of matrix maximum row sum,the accumulated interference of VUE can be constrained and the the SINR calculation complexity can be effectively reduced.In the MEC computation resource scheduling,by transforming the original optimization problem into a convex problem,the optimal task offloading proportion of VUE and MEC computation resource allocation can be obtained.The simulation further demonstrates that the JAWC algorithm can significantly reduce the total delay as well as ensure the communication reliability of VUE in the MEC-enabled vehicular network. | Yanzhao Hou Chengrui Wang Min Zhu Xiaodong Xu Xiaofeng Tao Xunchao Wu | 2021 | China Communications2021，18，6： | 4 |
| 15 | Bilayered HA/CS/PEGDA hydrogel with good biocompatibility and self-healing property for potential application in osteochondral defect repair显示文摘The fabrication of osteochondral tissue engineering scaffolds comprised of different layers is a big challenge. Herein, bilayers comprised of double network hydrogels with or without nano hydroxyapatite(HAp) were developed by exploiting the radical reaction of poly(ethylene glycol) diacrylate(PEGDA)and the Schiff-base reaction of N-carboxyethyl chitosan(CEC) and oxidized hyaluronic acid sodium(OHA) for osteochondral tissue engineering. The bilayered osteochondral scaffold was successfully fabricated based on the superior self-healing property of both hydrogels and evaluated by scanning electron microscopy, macroscopic observation and mechanical measurements. In addition, the hydrogels exhibited good biocompatibility as demonstrated by the in vitro cytotoxicity and in vivo implantation tests. The results indicated that the bilayered hydrogel had great potential for application in osteochondral tissue engineering. | Baihao You Qingtao Li Hua Dong Tao Huang Xiaodong Cao Hua Liao | 2018 | Journal of Materials Science & Technology2018，34，6： | 4 |
| 16 | Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271显示文摘Objective: Cancer metastasis remains the primary cause of cancer-related death worldwide.In a previous study, we found that levels of BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than in parental melanoma cells.The purpose of this study was to identify the roles of KCTD12 in cancer metastasis.Methods: The Cancer Genome Atlas(TCGA) datasets were used to evaluate the relationship between KCTD12 and skin cutaneous melanoma(SKCM) prognosis.The effects of endogenous KCTD12 on biological behaviors were examined using the MTT assay.The impacts of KCTD12 on melanoma stemness were explored using spheroid formation assay.KCTD12 knockout A375 cells were generated to confirm the inhibitory effect of KCTD12 on CD271, and a mouse metastatic model was used to determine the impact of KCTD12 on melanoma metastasis in vivo.Results: KCTD12 levels were lower in lung metastatic cells than in paired parental melanoma cells, and low KCTD12 expression indicated a poor prognosis in SKCM.Cancer metastasis-related capacities were higher in lung metastatic cells than in parental melanoma cells.Moreover, KCTD12 knockdown enhanced tumor growth and metastasis both in vitro and in vivo.Mechanistically, the interaction between KCTD12 and CD271 might be responsible for the stemness transformation after KCTD12 knockdown.Conclusions: This study identifies for the first time the role of the interaction between KCTD12 and CD271 in inducing melanoma cell stemness transformation.Moreover, KCTD12 repression enhances melanoma cell growth, adhesion, migration and invasion. | Weiyu Shen Yumei Li Bifei Li Liping Zheng Xiaodong Xie Jingqing Le Yusheng Lu Tao Li Fan Chen Lee Jia | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 17 | Preparation of fluidized catalytic cracking slurry oil-in-water emulsion as anti-collapse agent for drilling fluids显示文摘Fluidized catalytic cracking slurry oil-in-water emulsion(FCCSE)was prepared by using interfacial complexes generation method that was simple and versatile.The critical factors influencing the sample preparation process were optimized,for instance,the optimum value of the mixed hydrophile-lipophile balance of compound emulsifier was 11.36,the content of compound emulsifier was 4 wt%,the emulsification temperature was 75C,the agitation speed was 200 rpm,and the emulsification time was 30e45 min.The performance as a drilling fluid additive was also investigated with respect to rheological properties,filtration loss and inhibition of FCCSE.Experimental results showed that FCCSE was favorable to inhibiting clay expansion and dispersion and reducing fluid loss.Furthermore,it had good compatibility with other additives and did not affect the rheological properties of drilling fluids.FCCSE exhibited better performance than the available emulsified asphalt.It has a promising application as anti-collapse agent in petroleum and natural gas drilling. | Zhengqiang Xiong Shixian Tao Xiaodong Li Fan Fu Yanning Li | 2016 | Petroleum2016，2，4： | 4 |
| 18 | Damming effects on dissolved inorganic carbon in different kinds of reservoirs in Jialing River,Southwest China显示文摘To assess the effects of river damming on dissolved inorganic carbon in the Jialing River, a total of 40 water samples, including inflow, outflow, and stratified water in four cascade reservoirs(Tingzikou, Xinzheng,Dongxiguan, Caojie) were collected in January and July,2016. The major cations, anions, and δ^(13)C_(DIC) values were analyzed. It was found that the dissolved compositions are dominated by carbonate weathering, while sulfuric acids may play a relatively important role during carbonate weathering and increasing DIC concentration. Different reservoirs had variable characteristics of water physiochemical stratification. The DIC concentrations of reservoir water were lower in summer than those in winter due to the dilute effects and intensive aquatic photosynthesis, as well as imported tributaries. The δ^(13)C_(DIC) values in Tingzikou Reservoir were higher during summer than those in winter,which indicated that intensive photosynthesis increased the δ^(13)C_(DIC) values in residual water, but a similar trend was not obvious in other reservoirs. Except for in Xinzheng Reservoir, the δ^(13)C_(DIC) values in inflow and outflow reservoir water were lower than those in the surface water of stratified sampling in summer. For stratified sampling, it could be found that, in summer, the Tingzikou Reservoir δ^(13)C_(DIC) values significantly decreased with water depthdue to the anaerobic breakdown of organic matter. The significant correlation(p<0.01 or 0.05) between the DIC concentrations, the δ^(13)C_(DIC) values and anthropogenic species(Na^++K^+, Cl~–, SO_4^(2-) and NO_3^-) showed that the isotope composition of DIC can be a useful tracer of contaminants. In total, Tingzikou Reservoir showed lacustrine features, Xinzheng Reservoir and Dongxiguan Reservoir had 'transitional'' features, and Caojie Reservoir had a total of 'fluvial'' features. Generally, cascade reservoirs in the Jialing River exhibited natural river features rather than typical lake features due to characteristics of reservoir water in physiochemical stratification, spatiotemporal variations of DIC concentrations and isotopic compositions. It is evident that the dissolved inorganic carbon dynamics of natural rivers had been partly remolded by dam building. | Gaoyang Cui Xiaodong Li Qinkai Li Jun Huang Yuele Tao Siqi Li Jun Zhang | 2017 | Acta Geochimica2017，36，4： | 4 |
| 19 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 20 | Woofer–tweeter adaptive optical structured illumination microscopy显示文摘A woofer–tweeter adaptive optical structured illumination microscope(AOSIM) is presented. By combining a low-spatial-frequency large-stroke deformable mirror(woofer) with a high-spatial-frequency low-stroke deformable mirror(tweeter), we are able to remove both large-amplitude and high-order aberrations. In addition, using the structured illumination method, as compared to widefield microscopy, the AOSIM can accomplish highresolution imaging and possesses better sectioning capability. The AOSIM was tested by correcting a large aberration from a trial lens in the conjugate plane of the microscope objective aperture. The experimental results show that the AOSIM has a point spread function with an FWHM that is 140 nm wide(using a water immersion objective lens with NA=1.1) after correcting a large aberration(5.9 μm peak-to-valley wavefront error with 2.05 μm RMS aberration). After structured light illumination is applied, the results show that we are able to resolve two beads that are separated by 145 nm, 1.62× below the diffraction limit of 235 nm. Furthermore, we demonstrate the application of the AOSIM in the field of bioimaging. The sample under investigation was a green-fluorescentprotein-labeled Drosophila embryo. The aberrations from the refractive index mismatch between the microscope objective, the immersion fluid, the cover slip, and the sample itself are well corrected. Using AOSIM we were able to increase the SNR for our Drosophila embryo sample by 5×. | QINGGELE LI MARC REINIG DAICH KAMIYAMA BO HUANG XIAODONG TAO ALEX BARDALES JOEL KUBBY | 2017 | Photonics Research2017，5，4： | 3 |
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