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| 1 | Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms显示文摘In environmental risk assessments(ERA), biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes(e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function). To mitigate these limitations, the concept of adverse outcome pathways(AOPs) was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event(MIE) to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo(a)pyrene(Ba P), silver nanoparticles(Ag NPs), and selenium(Se). Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population levels.Also, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural environment.The development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem. | Jin Wuk Lee Eun-Ji Won Sheikh Raisuddin Jae-Seong Lee | 2015 | Journal of Environmental Sciences2015，27，9： | 7 |
| 2 | Development of RP-HPLC method for simultaneous determination of docetaxel and curcumin in rat plasma: Validation and stability显示文摘The purpose of the present research was to develop a suitable, simple, precise, accurate,robust, and reproducible RP-HPLC method for a reliable simultaneous quantification of docetaxel(DTX) and curcumin(CCM) in rat plasma samples using paclitaxel(PTX) as an internal standard. The samples were assayed by the Agilent 1260 Infinity HPLC instrument using a Capcell Pak C8 column(4.6 mm × 150 mm, 5 μm) under isocratic conditions. The mobile phase consisted of acetonitrile and triple distilled water(40/60, v/v) with a flow rate of 1.0 ml/min. The eluent was monitored at 230 nm for simultaneous measurement of curcumin and docetaxel. The method was validated by determining system suitability, selectivity, sensitivity, linearity, inter-day and intra-day precision, accuracy, robustness, and stability in accordance with the guidelines of the United States Food and Drug Administration(FDA).The developed chromatographic method proved to be simple, precise, accurate, robust and reproducible. Moreover, the samples showed stability at room temperature over a period of 48 h. Thus, this method would be employed for routine simultaneous quantification of docetaxel and curcumin in rat plasma samples. | Dong Wuk Kim Abid Mehmood Yousaf Dong Xun Li Jong Oh Kim Chul Soon Yong Kwan Hyung Cho Han-Gon Choi | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，1： | 3 |
| 3 | Lightweight deployment aware scheduling for wireless sensor networks显示文摘 | WuK Gao Y Li F Xiao Y | 2005 | Mobile Networks and Applications2005，10，6： | 1 |
| 4 | Biodegradable polymer blends of poly(L-lactic acid) and gelatinized starch显示文摘 | Park Jun Wuk | 2000 | Polym Eng Sci2000，40，12： | 1 |
| 5 | 2007 a nested case control study of plasma 25 - hydroxyvitamin D concentrations and risk of colorectal cancer显示文摘 | Wuk Feskanich D Fuchs CS | 2007 | J Natl Cancer Inst2007，99，： | 1 |
| 6 | Adrenaline stimulated cyclic adenosine monophosphate response in leukocytes is reduced after prolonged physical activity combined with sleep and energy deprivation显示文摘 | Wuk P Haugen AH | 1994 | Eur J Appl Physiol1994，，69： | 1 |
| 7 | Performance evaluation for general queueing networks in manufacturing systems: Characterizing the trade-off between queue time and utilization显示文摘 | WuK Mcginnis L | 2012 | European Journal of Operational Research2012，221，2： | 1 |
| 8 | The WRKY family of transcription factors in rice and Arabidopsis and their origins显示文摘 | WuK L Guo Z J Wang H H | 2005 | DNA Res2005，12，1： | 1 |
| 9 | The ecotoxicity of chlorate to aquatic organisms: a critical review显示文摘 | VAN WUK D J HUTCHINSON T H | 1995 | Ecotoxicology and Environmental Safety1995，32，： | 1 |
| 10 | Inter-and intra-or- ganizational knowledge transfer: a meta-analytic review and as- sessment of its antecedents and consequences 显示文摘 | Van WUK R JANSEN J J P LYLES M A | 2008 | Journal of Management Studies2008，45，4： | 1 |
| 11 | Multi-stepisothermalbainitictransformationinmedium-carbonsteel显示文摘 | WangXL WuK M HuF etal | 2014 | ScriptaMaterialia2014，74，： | 1 |
| 12 | Blood lead and cadmium le- vels and relevant factor in children from the e-wastes recycling town of Guiyu, China显示文摘 | ZHENG L WUK LIY etal | 2008 | Environment Research2008，108，1： | 1 |
| 13 | Screening and identification of mimotope of gastric cancer associated antigen MGb1-Ag显示文摘 | HANZY WUK C HEFT | 2003 | World Journal Gastroenterology2003，9，19： | 1 |
| 14 | Effect of matrix glycation on expression of typeIV collagen,MMP2,MMP9 and TIMP-l,by human messangial cells显示文摘 | Anderson SS Wuk J Nagase H | 1996 | Cell Adhesion Commun1996，4，1： | 1 |
| 15 | Abundance, polymorphism and ge- netic mapping of microsatellite in rice显示文摘 | Wuk S Tanksley SD | 1993 | Mol Gen Gen- et1993，241，： | 1 |
| 16 | Hydrolytic degradation behaviour and microstructural changes of poly(ester-co-amide)s显示文摘 | Soon Yeol Lee Jun Wuk Park Young Tai Yoo Seung Soon Im | 2002 | Polymer Degradation and Stability2002，，1： | 1 |
| 17 | A study on multistage centrifugal pump performance characteristics for variable speed drive system 显示文摘 | RAKIBUZZAMAN SUH S H KYUNG - WUK K | 2015 | Pro- cedia Engineering2015，，105： | 1 |
| 18 | I dentification of quantitative trait loci for carcass composition and pork quality traits in a commercial finishing cross 显示文摘 | van WUK H J DIBBITS B BARON E E | 2006 | J Anita Sci2006，84，4： | 1 |
| 19 | Isehemia cerebrovascular disease and poststroke depression 显示文摘 | Wuk Hu XS Wang ZW | | Zhonghua Laonian Yixue Zazhi0，19，2： | 1 |
| 20 | Hemostatic tasts in the predication of atherombotic disease显示文摘 | WuK K | 1997 | Int Hab Res1997，27，3： | 1 |
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