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| 1 | Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion显示文摘Beta-nerve growth factor(β-NGF)is known to be a major leading cause of neuronal plasticity.To identify the possible action mechanisms ofβ-NGF gene therapy for sciatic nerve recovery,experimental dogs were randomly divided into control,pyridoxine,and pyridoxine+β-NGF groups.We observed chronological changes of morphology in the dorsal root ganglia in response to pyridoxine toxicity based on cresyl violet staining.The number of large neurons positive for cresyl violet was dramatically decreased after pyridoxine intoxication for 7 days in the dorsal root ganglia and the neuron number was gradually increased after pyridoxine withdrawal.In addition,we also investigated the effects ofβ-NGF gene therapy on neuronal plasticity in pyridoxine-induced neuropathic dogs.To accomplish this,tyrosine kinase receptor A(TrkA),βIII-tubulin and doublecortin(DCX)immunohistochemical staining was performed at 3 days after the last pyridoxine treatment.TrkA-immunoreactive neurons were dramatically decreased in the pyridoxine group compared to the control group,but strong TrkA immunoreactivity was observed in the small-sized dorsal root ganglia in this group.TrkA immunoreactivity in the dorsal root ganglia was similar betweenβ-NGF and control groups.The numbers ofβⅢ-tubulin-and DCX-immunoreactive cells decreased significantly in the pyridoxine group compared to the control group.However,the reduction ofβⅢ-tubulin-and DCX-immunoreactive cells in the dorsal root ganglia in theβ-NGF group was significantly ameliorated than that in the pyridoxine group.These results indicate thatβ-NGF gene therapy is a powerful treatment of pyridoxine-induced neuropathic damage by increasing the TrkA and DCX levels in the dorsal root ganglia.The experimental protocol was approved by the Institutional Animal Care and Use Committee(IACUC)of Seoul National University,South Korea(approval No.SNU-060623-1,SNU-091009-1)on June 23,2006 and October 9,2009,respectively. | Hyun-Kee Cho Woosuk Kim Kwon-Young Lee Jin-Ok Ahn Jung Hoon Choi In Koo Hwang Jin-Young Chung | 2020 | Neural Regeneration Research2020，15，1： | 2 |
| 2 | Estimation of the parameters of blur type Ⅲ distribution based on dual generalized order statistics 显示文摘 | CHANSOO K WOOSUK K | 2014 | The Scientific World Journal2014，，51： | 1 |
| 3 | Production of theisoflavones genistein and daidzein in non-legume dicotand monocot tissues显示文摘 | Oliver Y Woosuk J June S | 2000 | Plant Physiology2000，124，2： | 1 |
| 4 | Shear-Flexure Coupling Behavior of Steel Fiber-Reinforced Concrete Beams显示文摘 | Kang Thomas H-K Kim Woosuk Massone Leonardo M Galleguillos Tito A | 2012 | EN2012，，4： | 1 |
| 5 | Shear testing of steel fiber-reinforced lightweight concrete beams without web reinforcement显示文摘 | Thomas H-K Kang Woosuk Kim Yoon-Keun Kwak Sung-Gul Hong | 2011 | Structural Journal2011，108，5： | 1 |
| 6 | Etiology and Pathogenesis of Achalasia:The Current Understanding显示文摘 | Michael F Vaezi | 2005 | Am J Gastroenterol2005，100，： | 1 |
| 7 | A membraneless microscale fuel cell using non-noble catalysts in alkaline solution 显示文摘 | Woosuk Sung Jin-Woo Choi | 2007 | Journal of Power Sources2007，172，1： | 1 |
| 8 | Melatonin improves d-galactose-in-duced aging effects on behavior, neurogenesis,and lipid peroxidation in the mouse dentategyrus via increasing pCREB expression 显示文摘 | Dae Y Y Woosuk K Choohg H L | 2012 | Journal of Pineal Research2012，52，： | 1 |
| 9 | Melatonin improves D-galactose-induced aging effects on behavior, neurogenesis and lipid peroxidation in the mouse dentate gyms via increasing pCREB expression显示文摘 | DAE Y Y WOOSUK K CHOOHG H L | 2012 | Journal of Pineal Research2012，52，： | 1 |
| 10 | Electronic structure of NaCo2O4显示文摘 | Woosuk S Norimitsu M | 2001 | Materials Letters2001，，49： | 1 |
| 11 | High-performance liquid chromatography with fluorescence detection for aqueous analysis of nanogram-level N-nitrosodimethylamine显示文摘 | Woosuk Cha Peter Fox Brijesh Nalinakumari | 2006 | Analytica Chimica Acta2006，566，1： | 1 |
| 12 | Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes显示文摘 | Woosuk J Oliver Yu | 2000 | Nature Biotechnology2000，18，： | 1 |
| 13 | Evaluation of steel slag for organic and inorganic removals in soil aquifer treatment显示文摘 | Woosuk Cha Jungwoo Kim Heechul Choi | 2006 | Water Research2006，，5： | 1 |
| 14 | High-performance liquid chromatography with fluorescence detection for queous analysis of nanogram-level N-nitrosodimethylamine显示文摘 | WOOSUK C PETER F BRIJESH NALINAKUMARI | 2006 | Analytica Chimica Acta2006，566，1： | 1 |
| 15 | Entacapone promotes hippocampal neurogenesis in mice显示文摘Entacapone,a catechol-O-methyltransferase inhibitor,can strengthen the therapeutic effects of levodopa on the treatment of Parkinson’s disease.However,few studies are reported on whether entacapone can affect hippocampal neurogenesis in mice.To investigate the effects of entacapone,a modulator of dopamine,on proliferating cells and immature neurons in the mouse hippocampal dentate gyrus,60 mice(7 weeks old)were randomly divided into a vehicle-treated group and the groups treated with 10,50,or 200 mg/kg entacapone.The results showed that 50 and 200 mg/kg entacapone increased the exploration time for novel object recognition.Immunohistochemical staining results revealed that after entacapone treatment,the numbers of Ki67-positive proliferating cells,doublecortin-positive immature neurons,and phosphorylated cAMP response element-binding protein(pCREB)-positive cells were significantly increased.Western blot analysis results revealed that treatment with tyrosine kinase receptor B(TrkB)receptor antagonist significantly decreased the exploration time for novel object recognition and inhibited the expression of phosphorylated TrkB and brain-derived neurotrophic factor(BDNF).Entacapone treatment antagonized the effects of TrkB receptor antagonist.These results suggest that entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB pathway.This study was approved by the Institutional Animal Care and Use Committee of Seoul National University(approval No.SNU-130730-1)on February 24,2014. | Dae Young Yoo Hyo Young Jung Woosuk Kim Kyu Ri Hahn Hyun Jung Kwon Sung Min Nam Jin Young Chung Yeo Sung Yoon Dae Won Kim In Koo Hwang | 2021 | Neural Regeneration Research2021，16，6： | 1 |
| 16 | Neuroprotective effects of adipose-derived stem cells against ischemic neuronal damage in the rabbit spinal cord显示文摘 | Jin Young Chung Woosuk Kim Wooseok Im Dae Young Yoo Jung Hoon Choi In Koo Hwang Moo-Ho Won In Bok Chang Byung Moon Cho Hyung Sik Hwang Seung Myung Moon | 2012 | Journal of the Neurological Sciences (-)2012，，1： | 1 |
| 17 | Synthesis and electrochemical properties of nonstoichiometric LiAlxMn2-xO4-d as cathode materials for rechargeable lithium ion battery显示文摘 | Woosuk Cho Wonkyung Ra Junichi Shirakawa | 2006 | Journal of Solid State Chemistry2006，179，： | 1 |
| 18 | Technical Note on a Track-pattern-based Model for Predicting Seasonal Tropical Cyclone Activity over the Western North Pacific显示文摘Recently, the National Typhoon Center (NTC) at the Korea Meteorological Administration launched a track-pattern-based model that predicts the horizontal distribution of tropical cyclone (TC) track density from June to October. This model is the first approach to target seasonal TC track clusters covering the entire western North Pacific (WNP) basin, and may represent a milestone for seasonal TC forecasting, using a simple statistical method that can be applied at weather operation centers. In this note, we describe the procedure of the track-pattern-based model with brief technical background to provide practical information on the use and operation of the model. The model comprises three major steps. First, long-term data of WNP TC tracks reveal seven climatological track clusters. Second, the TC counts for each cluster are predicted using a hybrid statistical-dynamical method, using the seasonal prediction of large-scale environments. Third, the final forecast map of track density is constructed by merging the spatial probabilities of the seven clusters and applying necessary bias corrections. Although the model is developed to issue the seasonal forecast in mid-May, it can be applied to alternative dates and target seasons following the procedure described in this note. Work continues on establishing an automatic system for this model at the NTC. | Chang-Hoi HO Joo-Hong KIM Hyeong-Seog KIM Woosuk CHOI Min-Hee LEE Hee-Dong YOO Tae-Ryong KIM Sangwook PARK | 2013 | Advances in Atmospheric Sciences2013，30，5： | 0 |
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