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| 1 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 2 | Sphincter preservation for distal rectal cancer - a goal worth achieving at all costs?显示文摘To assess the merits of currently available treatment options in the management of patients with low rectal cancer, a review of the medical literature pertaining to the operative and non-operative management of low rectal cancer was performed, with particular emphasis on sphincter preservation, oncological outcome, functional outcome, morbidity, quality of life, and patient preference. Low anterior resection (AR) is technically feasible in an increasing proportion of patients with low rectal cancer. The cost of sphincter preservation is the risk of morbidity and poor functional outcome in a significant proportion of patients. Transanal and endoscopic surgery are attractive options in selected patients that can provide satisfactory oncological outcomes while avoiding the morbidity and functional sequelae of open total mesorectal excision. In complete responders to neo-adjuvant chemoradiotherapy, a non-operative approach may prove to be an option. Abdominoperineal excision (APE) imposes a permanent stoma and is associated with significant incidence of perineal morbidity but avoids the risk of poor functional outcome following AR. Quality of life following AR and APE is comparable. Given the choice, most patients will choose AR over APE, however patients following APE positively appraise this option. In striving toward sphincter preservation the challenge is not only to achieve the best possible oncological outcome, but also to ensure that patients with low rectal cancer have realistic and accurate expectations of their treatment choice so that the best possible overall outcome can be obtained by each individual. | Jürgen Mulsow Des C Winter | 2011 | World Journal of Gastroenterology2011，17，7： | 2 |
| 3 | Formation of micronuclei in erythrocytes of the fathead minnow (Pimcphales promelas) after acute treatment with mitomycin C or cyclophosphamide 显示文摘 | WINTER M J ELLIS L C HUTCHINSON T H | 2007 | Mut Res2007，629，2： | 1 |
| 4 | Man-made antibodies显示文摘 | Milstein C | 1991 | Nature1991，349，6307： | 1 |
| 5 | Man-made antibody 显示文摘 | Winter G Milstein C | 1991 | Nature1991，349，6307： | 1 |
| 6 | Mesophilic and thermophilic anaerobic digestion of source-sorted organic wastes:effect of ammonia on glucose degradation and methane production显示文摘 | Gallert C Winter J | 2013 | Applied Microbiology Biotechnology2013，48，： | 1 |
| 7 | p-nitrobenzol-d(-)-and paminobenzoyl-d(-)-glutamic acid显示文摘 | Winter H C | 1940 | J A C S1940，62，： | 1 |
| 8 | Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival显示文摘 | HANLY A M REDMOND M WINTER D C | 2006 | Br J Cancer2006，94，9： | 1 |
| 9 | The role of permafrost and seasonal frost in the hydrology of northern wetlands in North America显示文摘 | Woo M-K Winter T C | 1993 | Journal of Hydrology1993，，141： | 1 |
| 10 | Molecular identification of a volume regulated chloride channel显示文摘 | Duan D Winter C Cowley S | 1997 | Nature1997，390，： | 1 |
| 11 | Cosmic ray production rates of tBe and 26A1 in quartz from glacially polished roeks 显示文摘 | Nishiizumi K Winterer E L Kohl C P | 1989 | Journal of Geophysical Research1989，94，17： | 1 |
| 12 | Lung Injury in Acute Pancreatitis: Mechanisms, Prevention, and Therapy显示文摘 | Shields C J Winter D C Redmond H P | 2002 | Curr Opin Crit Care2002，8，2： | 1 |
| 13 | Manmade antibodies显示文摘 | Winter G Milstein C | 1991 | Nature1991，349，： | 1 |
| 14 | Effect of Ammonia on the Anaerobic Degradation of Protein by a Mesophilic and Thermophilic Biowaste Population显示文摘 | GALLERT C BAUER S WINTER J | 1998 | Applied Microbiology Biotechnology1998，50，4： | 1 |
| 15 | DGAT1, a new positional and functional candidate gene for intramuscular fat deposition in cattle显示文摘 | Kuhn C Winter A | 2003 | Anim Genet2003，34，5： | 1 |
| 16 | Biodistribution and dosimetry of 99mTc-ciprofloxacin,a promising agents for diagnosis of bacterial infection显示文摘 | de Winter F Van de Wiele C Dumont F | 2001 | Eur J Nucl Med2001，28，： | 1 |
| 17 | Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae 显示文摘 | Winter C Herbold W Maus R | 2009 | J Immunol2009，182，8： | 1 |
| 18 | Microbubbles as ultrasound triggered drug carriers 显示文摘 | Tinkov R Bekeredjian G Winter C | 2009 | Pharm Sci2009，98，6： | 1 |
| 19 | Metal trafficking in earthworms-identification of a cadmium specific metallothionein显示文摘 | Sturzenbaum S R Winters C Galay M | 2001 | J Biol Chem2001，276，34： | 1 |
| 20 | Effect of implantable cardioverter/ defibrillator lead placement in the right ventricle on defibrillation energy requirements:A combined experimental and clinical study显示文摘 | WINTER J HEIL J E SCHUMANN C | 1998 | Eur J Cardiothorac Surg1998，14，： | 1 |
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