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| 1 | Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus infection treated with interferon-α显示文摘AIM: To evaluate the prevalence of autoantibodies in chronic hepatitis C virus (HCV)-infected children focusing on thyroid autoimmunity. METHODS: We investigated the prevalence of auto- antibodies in 123 chronic HCV-infected children before, during and after monotherapy with interferon-alpha (IFN-α) or combined treatment with interferon-α or peginterferon-α and ribavirin. Besides antibodies against smooth muscle (SMA), nuclei (ANA), and liver/kidney microsomes (LKM), the incidence of anti- thyroid peroxidase antibodies as well as thyroid function parameters (TSH, FT3 and FT4) were determined. RESULTS: We found that 8% of children had autoantibodies before treatment. During treatment, 18% of children were found positive for at least one autoantibody; 15.5% of children developed pathologic thyroid values during IFN-α treatment compared to only one child before therapy. Six children had to be substituted while developing laboratory signs of hypothyroidism. CONCLUSION: Our data indicate a strong correlation between interferon-α treatment and autoimmune phenomena, notably the emergence of thyroid antibodies. The fact that some children required hormone replacement underlines the need of close monitoring in particularly those who respond to therapy and have to be treated for more than 6 mo. | Stephan Gehring Ulrike Kullmer Sabine Koeppelmann Patrick Gerner Philip Wintermeyer Stefan Wirth | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 2 | Endoscopic ultrasound of the colon for the differentiation of Crohn’s disease and ulcerative colitis in comparison with healthy controls显示文摘 | M. Ellrichmann P. Wietzke‐Braun S. Dhar S. Nikolaus A. Arlt J. Bethge T. Kuehbacher L. Wintermeyer K. Balschun W. Klapper S. Schreiber A. Fritscher‐Ravens | 2014 | Aliment Pharmacol Ther2014，，8： | 2 |
| 3 | Colicins and their potential in cancer treatment显示文摘 | LANCASTER L E WINTERMEYER W RODNINA M V | 2007 | Blood Cells Mol Dis2007，38，1： | 1 |
| 4 | Positive oder negative Fruktose-Atemtestergebnisse lassen keinen Schluss auf die Reaktion auf eine Fruktose-reduzierte Ern?hrung zu: Ergebnisse einer prospektiven randomisierten Studie显示文摘 | S. Wirth C. Klodt P. Wintermeyer J. Berrang K. Hensel T. Langer A. Heusch | 2014 | Klin Padiatr2014，，05： | 1 |
| 5 | Pulmonary responses to purified zinc oxide fume 显示文摘 | KUSCHNER W G D' ALESSANDRO A WINTERMEYER S F | 1995 | J Investig Med1995，43，4： | 1 |
| 6 | Chronic ethanol consumption impairs cellular immune responses against HCV NS5 protein due to dendritic cell dysfunction 显示文摘 | Aloman C Gehring S Wintermeyer P | 2007 | Gastroenterology2007，132，： | 1 |
| 7 | Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome 显示文摘 | PAPE T WINTERMEYER W RODNINA M | 1999 | Embo J1999，18，： | 1 |
| 8 | Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage显示文摘 | Wintermeyer P Cheng CW Gehring S | 2009 | Gastroenterology2009，136，3： | 1 |
| 9 | Chronic alcohol consumption impairs cellular immune responses against HCV NS5 protein due to dendritic cell dysfunction显示文摘 | Aloman C Gehring S Wintermeyer P | 2007 | Gastroenterology2007，132，2： | 1 |
| 10 | Relationship between viral load and genotypes of hepatitis B virus in children with chronic hepatitis B显示文摘 | Oommen PT Wirth S Wintermeyer P | 2006 | J Pediatr Gastroenterol Nutr2006，43，3： | 1 |
| 11 | GTPase activation of elongation factors Tu and G on the ribosome显示文摘 | Mohr D Wintermeyer W Rodnina MV | 2002 | Biochemistry2002，41，12： | 1 |
| 12 | Medical surveillance of workers exposed to crystalline silica 显示文摘 | Lawrence W Raymond Stephen Wintermeyer | 2006 | Acoem Evidence-based Statement2006，48，1： | 1 |
| 13 | Colicins and their potential in cancer treatment显示文摘 | Lancaster L E Wintermeyer W Rodnina M V | 2007 | Blood Cells Mol Dis2007，38，1： | 1 |
| 14 | Patterns of genetic variation within and among gypsy moth, Lymantria dispar (Lepidoptera: Lymantriidae), populations显示文摘 | Harrison R G Wintermeyer S F Odell T M | 1983 | Annals of the Entomological Society of America1983，76，4： | 1 |
| 15 | Prevalence of hepatitis B virus precore stop codon mutations in chronically infected children显示文摘瞄准:为了发现是否在 precore 站的流行有有效差量,在在积极的 HBeAg 和 anti-HBe 之间的变化上哄骗积极孩子。方法:我们调查了 155 个欧洲孩子的一张大小儿科的人口(意味着年龄 10.9 年) 与由 PCR 并且直接定序的长期的肝炎 B。90 是积极的 HBeAg 和 65 有的 seroconversion 到 anti-HBe。另外, genotyping 被执行。结果:(48%) 74 定序的 HBV 紧张被归因于遗传型 D 并且 81 (52%) 到遗传型 A。在 90 个 HBeAg 积极病人的组, 2 (2.2%) 变化上的 1896-G-to-A 转变导致 precore 站鳕鱼被发现,并且在 65 anti-HBe 的组积极孩子,(7.7%) 5 被识别 harbouring HBeAg 减异种。差别不是统计上重要的(P = 0.13 ) 。结论:减占优势的病毒的 HB 紧张在欧洲孩子在长期的肝炎 B 期间起一个次要的作用的变体的 HBeAg。 | Philip Wintermeyer Patrick Gerner Stephan Gehring Afshin Karimi Stefan Wirth | 2006 | World Journal of Gastroenterology2006，12，14： | 1 |
| 16 | Relationship between viral load and genotypes of hepatitis B virus in children with chronic hepatitis B 显示文摘 | Oommen PT Wirth S Wintermeyer P | 2006 | J Pediatr Gastroenterol Nutr2006，43，3： | 1 |
| 17 | Relationship Between Viral Load and Genotypes of Hepatitis B Virus in Children With Chronic Hepatitis B显示文摘 | Prasad T. Oommen Stefan Wirth Philip Wintermeyer Patrick Gerner | 2006 | Journal of Pediatric Gastroenterology and Nutrition2006，，3： | 1 |
| 18 | Spatial and tempotral frequency tuning of pattern reversal retinal potentials显示文摘 | TRICK G L WINTERMEYER D H | 1982 | Invest Ophthalmol Vis Sci1982，23，： | 1 |
| 19 | Prevalence of hepatitis C virus infection in children admitted to an urban hospital显示文摘 | Patrick Gerner Stefan Wirth Philip Wintermeyer Alexander Walz Andreas Jenke | 2005 | Journal of Infection2005，，4： | 1 |
| 20 | Invariant natural killer T cells suppress the neutmphil inflammatory response in a mouse model of cholestatic liver damage 显示文摘 | Wintermeyer P Cheng CW Gehring S | 2009 | Gastroenterology2009，136，3： | 1 |
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