|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus infection treated with interferon-α显示文摘AIM: To evaluate the prevalence of autoantibodies in chronic hepatitis C virus (HCV)-infected children focusing on thyroid autoimmunity. METHODS: We investigated the prevalence of auto- antibodies in 123 chronic HCV-infected children before, during and after monotherapy with interferon-alpha (IFN-α) or combined treatment with interferon-α or peginterferon-α and ribavirin. Besides antibodies against smooth muscle (SMA), nuclei (ANA), and liver/kidney microsomes (LKM), the incidence of anti- thyroid peroxidase antibodies as well as thyroid function parameters (TSH, FT3 and FT4) were determined. RESULTS: We found that 8% of children had autoantibodies before treatment. During treatment, 18% of children were found positive for at least one autoantibody; 15.5% of children developed pathologic thyroid values during IFN-α treatment compared to only one child before therapy. Six children had to be substituted while developing laboratory signs of hypothyroidism. CONCLUSION: Our data indicate a strong correlation between interferon-α treatment and autoimmune phenomena, notably the emergence of thyroid antibodies. The fact that some children required hormone replacement underlines the need of close monitoring in particularly those who respond to therapy and have to be treated for more than 6 mo. | Stephan Gehring Ulrike Kullmer Sabine Koeppelmann Patrick Gerner Philip Wintermeyer Stefan Wirth | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 2 | Re-treatment of Children With Chronic Hepatitis C Who Did Not Respond to Interferon-α Treatment显示文摘 | Patrick Gerner Juliane Hilbich Tobias G Wenzl Rolf Behrens Frank Walther Guido Kliemann Axel Enninger Stefan Wirth | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 3 | The Hepatitis B Virus Seroconversion to Anti-HBe Is Frequently Associated with HBV Genotype Changes and Selection of preS2-Defective Particles in Chronically Infected Children显示文摘 | Patrick R. Gerner Michael Friedt Robert Oettinger Ekkehart Lausch Stefan Wirth | 1998 | Virology1998，，1： | 1 |
| 4 | Recombinant alfa-interferon plus ribavirin therapy in children and adolescents with chronic hepatitis C显示文摘 | Stefan Wirth Thomas Lang Stephan Gehring Patrick Gerner | 2002 | Hepatology2002，，5： | 1 |
| 5 | Prevalence of hepatitis B virus precore stop codon mutations in chronically infected children显示文摘瞄准:为了发现是否在 precore 站的流行有有效差量,在在积极的 HBeAg 和 anti-HBe 之间的变化上哄骗积极孩子。方法:我们调查了 155 个欧洲孩子的一张大小儿科的人口(意味着年龄 10.9 年) 与由 PCR 并且直接定序的长期的肝炎 B。90 是积极的 HBeAg 和 65 有的 seroconversion 到 anti-HBe。另外, genotyping 被执行。结果:(48%) 74 定序的 HBV 紧张被归因于遗传型 D 并且 81 (52%) 到遗传型 A。在 90 个 HBeAg 积极病人的组, 2 (2.2%) 变化上的 1896-G-to-A 转变导致 precore 站鳕鱼被发现,并且在 65 anti-HBe 的组积极孩子,(7.7%) 5 被识别 harbouring HBeAg 减异种。差别不是统计上重要的(P = 0.13 ) 。结论:减占优势的病毒的 HB 紧张在欧洲孩子在长期的肝炎 B 期间起一个次要的作用的变体的 HBeAg。 | Philip Wintermeyer Patrick Gerner Stephan Gehring Afshin Karimi Stefan Wirth | 2006 | World Journal of Gastroenterology2006，12，14： | 1 |
| 6 | Relationship Between Viral Load and Genotypes of Hepatitis B Virus in Children With Chronic Hepatitis B显示文摘 | Prasad T. Oommen Stefan Wirth Philip Wintermeyer Patrick Gerner | 2006 | Journal of Pediatric Gastroenterology and Nutrition2006，，3： | 1 |
| 7 | Prevalence of hepatitis C virus infection in children admitted to an urban hospital显示文摘 | Patrick Gerner Stefan Wirth Philip Wintermeyer Alexander Walz Andreas Jenke | 2005 | Journal of Infection2005，，4： | 1 |
| 8 | Vitamin E treatment for children with chronic hepatitis B:A randomized placebo controlled trial显示文摘AIM:To evaluate the safety and efficacy of vitamin E in children with chronic hepatitis B.METHODS:We randomly assigned patients with chronic hepatitis B,positive for hepatitis B e antigen(HBeAg),to receive either vitamin E or placebo once daily for 6 mo in a 3:1 ratio and double-blind manner.The primary end point was HBeAg seroconversion,defined as the loss of HBeAg,undetectable levels of serum hepatitis B virus DNA,and the appearance of antibodies against HBeAg 12 mo after therapy.RESULTS:At baseline visit,49 patients had normal and 43 had increased serum aminotransferase levels.Twenty-nine patients did not respond to previous treatment with interferon-α or lamivudine.Seventy-six children completed the study;16 were non-compliant(n = 7),lost to follow-up(n = 7),or started another antiviral treatment(n = 3).Intention-to-treat analysis showed HBeAg seroconversion in 16 children(23.2%) treated with vitamin E and two(8.7%) in the placebo group(P = 0.13).Vitamin E was well tolerated.CONCLUSION:There is only a tendency that vitamin E may promote HBeAg seroconversion.Therefore larger studies are needed to clarify the role of antioxidants in the therapy of chronic hepatitis B. | Patrick Gerner Hans-Georg Posselt Andreas Krahl Antje Ballauff Albina Innerhofer Christa Binder Tobias G Wenzl Matthias Zense Ariadne Hector Gerhard Dockter Rüdiger Adam Jenny Neubert Martin Claβen Robert van Gemmern Stefan Wirth | 2008 | World Journal of Gastroenterology2008，14，47： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员