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| 1 | Earthquake relocation and 3-dimensional crustal structure of P-wave velocity in cen-tral-western China显示文摘采用中国中西部地区(2l°~36°N,98°~112°E)193个地震台在1992~1999年间记录到的9988次地震的Pg和Sg震相走时的读数资料,用Roecker的SPHYPIT90程序,反演了该地区三维地壳P波速度结构,并用SPHREL3D90程序进行了地震的重新定位.反演结果揭示了中国中西部地区地震P波速度结构明显的横向不均匀性,这些不同深度上波速的横向变化多以该地区的活动断裂为分界线.可以看出活动断裂两侧存在明显的速度反差.通过重新定位,得到了6459次地震的震源参数,这些精确定位的地震震中明显沿该区活动断裂呈现条带状分布,其范围和尺度清晰地表示了这一地区地震活动与活动断裂的紧密关系.其中,82%重新精确定位的事件的震源深度在20km以内.这一结果与笔者用双差地震定位法得到的重新定位的震源深度分布相一致. | 杨智娴 于湘伟 郑月军 陈运泰 倪晓晞 Winston CHAN | 2004 | 地震学报2004，26，1： | 26 |
| 2 | 不同程度慢性牙周炎患者病情的二年自然进展显示文摘目的 观察不同程度慢性牙周炎的自然进展规律。方法 纵向观察 16 9例轻、中、重度慢性牙周炎患者在 2年中的疾病自然进展 ,检查除第三磨牙外的全口牙 ,每颗牙 6个位点 ,以探诊深度、附着丧失为指标 ,两次检查之间附着丧失加重≥ 3mm的牙位定为活动性进展。结果 活动性发生率依基线时疾病的轻、中、重程度而逐渐增高 ,按位点活动性的发生率分别为 0 14 %、0 39%及0 73% ,按个体活动性的发生率分别为 15 5 6 %、2 9 89%及 4 3 2 4 % ,差异有统计学意义。结论 重度牙周炎患者是牙周破坏活动性进展的高危人群。 | 欧阳翔英 曹采方 Henry Liu 胡文杰 J Leslie Winston | 2004 | 中华口腔医学杂志2004，39，3： | 24 |
| 3 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 4 | 200例慢性牙周炎患者的病情调查显示文摘目的 调查城区职工中未经治疗的慢性牙周炎患者的疾病状况。方法 从北京城区某单位职工中筛选出未经治疗的慢性牙周炎患者 2 0 0例 ,检查除第三磨牙外的全口牙、6个位点 /牙的牙周情况 ,指标为探诊深度、附着丧失、探诊后出血。结果 附着丧失程度随患者的年龄增长而加重 ,男性的附着丧失重于女性 ,探诊出血位点的附着丧失重于不出血位点。在全口牙中 ,下切牙和上颌第一磨牙的附着丧失最多。结论 慢性牙周炎的程度与年龄、性别、牙龈炎症有关 ,病变的分布有牙位特异性。 | 欧阳翔英 曹采方 胡文杰 王鸿颖 J.Leslie Winston Henry Liu | 2004 | 现代口腔医学杂志2004，18，4： | 13 |
| 5 | 让肾脏健康人人可享,处处可及——从预防到诊治显示文摘Around 850 million people currently are affected by different types of kidney disorders.Up to 1 in 10 adults worldwide has chronic kidney disease(CKD),which is invariably irreversible and mostly progressive.The global burden of CKD is increasing,and CKD is projected to become the fifth most common cause of years of life lost globally by 2040.If CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease,CKD progresses to endstage kidney disease,where life cannot be sustained without dialysis therapy or kidney transplantation.Hence,CKD is a major cause of catastrophic health expenditure. | Philip Kam Tao Guillermo Garcia Garcia Siu Fai Lui Sharon Andreoli Winston Wing Shing Fung Anne Hradsky Latha Kumaraswami Vassilios Liakopoulos Ziyoda Rakhimova Gamal Saadi Luisa Strani Ifeoma Ulasi Kamyar Kalantar Zadeh 无 | 2020 | 肾脏病与透析肾移植杂志2020，29，1： | 6 |
| 6 | Gut Microbiota in Metabolic-associated Fatty Liver Disease and in Other Chronic Metabolic Diseases显示文摘The gut microbiome plays a key role in the health-disease balance in the human body.Although its composition is unique for each person and tends to remain stable throughout lifetime,it has been shown that certain bacterial patterns may be determining factors in the onset of certain chronic metabolic diseases,such as type 2 diabetes mellitus(T2DM),obesity,metabolic-associated fatty liver disease(MAFLD),and metabolic syndrome.The gut-liver axis embodies the close relationship between the gut and the liver;disturbance of the normal gut microbiota,also known as dysbiosis,may lead to a cascade of mechanisms that modify the epithelial properties and facilitate bacterial translocation.Regulation of gut microbiota is fundamental to maintaining gut integrity,as well as the bile acids composition.In the present review,we summarize the current knowledge regarding the microbiota,bile acids composition and their association with MAFLD,obesity,T2DM and metabolic syndrome. | Winston Hernández-Ceballos Jacqueline Cordova-Gallardo Nahum Mendez-Sanchez | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 6 |
| 7 | Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes显示文摘Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. | Marcello C Bertoluci Gislaine V Cé Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales | 2015 | World Journal of Diabetes2015，6，5： | 5 |
| 8 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
| 9 | Characteristics of the Chinese subjects entered the Hypertension in the Very Elderly Trial显示文摘在多民族的试用的病人的基线特征是的背景可能,与比较的心血管的 outcome.This 学习有关,病人的基线特征在中国招募了,那些在超过 80 年岁的 508 个中国高血压的男人和进入了高血压在的 728 个女人全部的另外的 countries.Methods A 招募了老试用( HYVET )与在 860 个男人和在另外的 countries.Results 进入了试用的 1 348 个女人的那些相比中国 | LIU Li-sheng WANG Ji-guang MA Shu-ping WANG Wen LU Fang-hong ZHANG Liang-qing Winston Banya Ruth Peters Nigel Beckett Astrid Fletcher Christopher J. Bulpitt | 2008 | Chinese Medical Journal2008，，16： | 5 |
| 10 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 11 | Solvent-free nanocasting toward universal synthesis of ordered mesoporous transition metal sulfide@N-doped carbon composites for electrochemical applications显示文摘Transition metal sulfides (TMSs) have a wide range of applications owing to their intriguing properties.Significant efforts have been devoted to nanostructuring TMSs to enhance their properties and performance,still there is a high need in general synthesis of TMS nanostructures.Herein,for the first time,a simple solvent free reactive nanocasting approach that integrates solid precursor loading,in-situ sulfuration and carbonization into a single heating step is developed for the universal synthesis of ordered mesoporous TMS@N-doped carbon composites (denoted as OM-TMS@NCs) with methionine (Met) and metal chlorides as the precursors and the mesoporous silica (SBA-15) as the hard template.A series of OM-TMS@NCs with a hexagonal mesostructure,ultra-high surface areas (430-754 m2·g-1),large pore volumes (0.85-1.32 cm3·g-1),and unique TMS stoichiometries,including MoS2,Fe7S8,Co9S8,NiS,Cu7S4 and ZnS,are obtained.Two distinct structure configurations,namely,highly dispersed ultrathin TMS nanosheets within NCs and TMS@NC co-nanowire arrays,can be obtained depending on different metals.The structure evolution of the OM-TMS@NCs over the solvent-free nanocasting process is studied in detail for a deep understanding of the synthesis.As demonstrations,these materials are promising for electrocatalytic hydrogen evolution reaction and lithium ion storage with high performances. | Jiahui Zhu Zhi Chen Lin Jia Yuqi Lu Xiangru Wei Xiaoning Wang Winston Duo Wu Na Han Yanguang Li Zhangxiong Wu | 2019 | Nano Research2019，12，9： | 5 |
| 12 | 缅甸和中国的非正式跨国界流动显示文摘西方国家对缅甸长达十余年的经济制裁严重阻碍了缅甸经济的发展。由于与发达国家的贸易异常艰难,缅甸贸易的中心转向邻国。本文分析了缅甸和中国非正式跨国界物资和人员流动的原因和影响,提出的对策建议包括:两国的管理部门之间要加强合作,将非正式流动顺利转变为正式流动。通过合作,重新认真审查和修订为非正式流动制定的限制性政策法规,降低非正式流动对当地社区的社会和经济造成的负面影响。文章提出只有利益相关各方长期合作共同制定多维政策,应对多维问题,才能实现双赢的局面。 | Winston Set Aung 张成霞 | 2011 | 东南亚纵横2011，，2： | 5 |
| 13 | Dickkopfs分泌蛋白调控肿瘤细胞机制显示文摘Dickkopfs是Wnt/β-catenin信号通路的抑制因子,具有抑制肿瘤生长的作用。Dickkopfs分泌蛋白可用作临床诊断和治疗的靶点,因此,有关Dickkopfs分泌蛋白精准有效调控肿瘤细胞机制及靶向抑制剂的研究,是癌症研究中重要的研究对象之一。目前的研究对Dickkopfs蛋白家族缺乏系统性归纳,因此对Dickkopfs在肿瘤细胞中的调控机制进行分析。结果发现:DKK1、DKK2、DKK4主要通过引起蛋白酶体β-catenin降解、诱导细胞凋亡和阻止细胞增殖来抑制Wnt/β-catenin通路;DKK3是通过对β-catenin的下游信号通路因子进行负调控的详细机制。阐述了Dickkopfs分泌蛋白在临床诊断、治疗及预后的应用,并对其可能存在抑制肿瘤血管生成机制进行了展望。 | 陈曦 孙延芳 WINSTON Nxumalo | 2020 | 浙江理工大学学报(自然科学版)2020，43，2： | 5 |
| 14 | Loss of IKB kinase βpromotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop显示文摘 | Liang Chen Zhimin Peng Qinghang Meng Maureen Mongan Jingcai Wang Maureen Sartor Jing-Chen Liang Niu Mario Medvedovic Winston Kao Ying Xia | 2016 | Protein & Cell2016，7，5： | 4 |
| 15 | 血管生成素-1对猪慢性缺血心肌中功能性新生血管增生的促进作用显示文摘目的对比血管生成素-1(angiopoietin-1,ANG-1)和血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)在猪慢性心肌缺血模型中的促血管再生效果。方法利用Ameroid血管压缩环建立26只猪慢性心肌缺血研究模型,4周后分成3组:腺病毒携带ANG-1组(Ad ANG-1,n=9),腺病毒携带VEGF组完全恢复灌注术后4周仍然保持缺血状态(Ad VEGF,n=10)和空载体对照组(n=7)。分别在腺病毒介导的基因移植4和12周后,利用荧光微球法测定缺血心肌的局部血流量,并同时进行免疫组化检测。结果基因移植后4周,Ad ANG-1组左心室心肌缺血区的灌注量[(3.25±0.16)m Lmin-1g-1]明显高于Ad VEGF组[(1.09±0.13)m Lmin-1g-1]和对照组[(1.20±0.03)m Lmin-1g-1](P<0.05)。基因移植后12周,Ad ANG-1组和Ad VEGF组的左心室缺血区心肌微血管密度分别为(19.61±1.76)/0.572 mm2心肌组织和(18.17±1.43)/0.572 mm2心肌组织,均明显高于对照组的(13.53±0.92)/0.572 mm2心肌组织(P<0.05)。但就直径50~100μm小动脉密度而言,Ad ANG-1组较空载体对照组显著增加[(1.9±0.4)/0.572 mm2心肌组织切面vs.(0.7±0.2)/0.572 mm2心肌组织切面,P<0.05],而VEGF组与空载体对照组相较则无明显差异。Ad ANG-1组增加了心肌微血管的密度进而提高了局部心肌灌注。结论 VEGF和ANG-1基因转移均可促进血管再生,但只有ANG-1可以促进功能性小血管的再生,从而稳定有效地增加了心肌灌注,并为心功能的改善提供了必要的组织解剖学基础。 | 李伟 Winston Ng Shim Eugene Kwangwei Sim | 2018 | 复旦学报(医学版)2018，45，3： | 4 |
| 16 | Landscape configuration and urban heat island effects: assessing the relationship between landscape characteristics and land surface temperature in Phoenix, Arizona显示文摘 | John Patrick Connors Christopher S. Galletti Winston T. L. Chow | 2013 | Landscape Ecology2013，，2： | 3 |
| 17 | GISAID’s Role in Pandemic Response显示文摘GISAID is a global data science initiative and the primary source of genomic and associated metadata of all influenza viruses,Respiratory Syncytial Virus(RSV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pandemic coronavirus causing coronavirus disease 2019(COVID-19).GISAID’s publicly accessible data sharing platform enables collaboration of over 42,000 participating researchers from 198 nations and data generators from over 3,500 institutions across the globe.Since the first wholegenome sequences were made available by China CDC through GISAID on January 10. | Shruti Khare Céline Gurry Lucas Freitas Mark B Schultz Gunter Bach Amadou Diallo Nancy Akite Joses Ho Raphael TC Lee Winston Yeo GISAID Core Curation Team Sebastian Maurer-Stroh | 2021 | China CDC weekly2021，3，49： | 3 |
| 18 | Optimal time for delivery with preterm premature rupture of membranes from 32 to 36 6/7 weeks显示文摘 | Christopher Nold Naveed Hussain Kathleen Smith Winston Campbell Adam Borgida James Egan | 2011 | Journal of Maternal-Fetal and Neonatal Medicine2011，，7： | 3 |
| 19 | 基于Copula贝叶斯估计的行业风险差异分析显示文摘通过对常替代弹性资本资产定价模型中投资标度问题的分析,提出了Copula贝叶斯估计方法用以获得系统风险β与投资标度比λ的联合后验分布.Copula贝叶斯估计方法针对数据非正态特征及强相关性特征而构建,采用Copula函数取代原有普通贝叶斯估计方法中的正态假设.传统贝叶斯估计方法假设了正态的似然函数,忽略了数据可能存在尖峰后尾等在金融实证数据分析中普遍存在的非正态情况.Copula贝叶斯估计算法采用半相依回归法处理数据的强相关性问题,将原有函数依照数据形式假设为非正态结构.针对来自6个工业产业24组公司数据的系统风险参数β与其对应的投资标度参数比λ进行估计,获得不同行业中系统风险参数与投资标度之间的动态关系并进行分析,为业界投资及相关研究提供有效参考建议. | 赵宁 Winston T Lin 孙雪卿 | 2015 | 数学的实践与认识2015，45，10： | 3 |
| 20 | 基于医学影像的血流动力学分析显示文摘随着计算机成像技术的发展,计算机断层扫描(CT)和核磁共振(MRI)已经广泛应用于临床,特别是血管类疾病的诊断,比如动脉狭窄、血管瘤、血管畸形等.除了可以提供高分辨率的静态图像,先进的MRI技术还可以通过时间序列直接反映血流动力学的变化.而基于计算机成像和三维重建技术,血流动力学的参数又可以通过计算流体力学的方法进行详细的分析.如何将血流动力学参数和临床诊断相结合是近年来在转化医学领域研究的热点.文中将结合文献调研和作者自己的研究工作对基于医学图像的血流动力学分析进行综述,并探讨未来的研究方向. | 陈宇 李睿 赵雪梅 李东海 徐文娟 刘爱华 Sia Sheau Fung Chong Winston 张宇 | 2016 | 力学进展2016，46，1： | 3 |
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