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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Hepatitis B virus reactiva- tion in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab 显示文摘 | Winnie Yeo Tung C Nancy WY | 2009 | Journal Of Clinical Oncology2009，27，4： | 1 |
| 3 | Early appraisal of China' s huge and complex health-care reforms显示文摘 | Winnie Chi-Man Yip W C H W | 2012 | Lancet2012，379，： | 1 |
| 4 | Peer assessment of language proficiency显示文摘 | Winnie C Martin W | 2005 | Language Testing2005，22，1： | 1 |
| 5 | Cooperative and Competitive Conflict for Quality Supply Partnerships between China and Hong Kong 显示文摘 | Alfred Wong Dean Tjosvold Winnie Y L Wong C K Liu | 1999 | International Journal of Physical Distribution & Logistics Management1999，29，1： | 1 |
| 6 | Particulate matter (PM) concentra- tions in underground and ground-level rail systems of the Los Angeles Metro显示文摘 | Winnie K Kalam C Nancy D | 2011 | Atmos Environ2011，45，： | 1 |
| 7 | Success or failure:selectivity and reasons of return migration in Sichuan andAnhui, China 显示文摘 | Wenfei Winnie Wang C Candy Fan | 2006 | Environment and Planning A2006，38，： | 1 |
| 8 | Hsiao,' Market Watch: The Chinese Health System at a Crossroads'显示文摘 | Winnie Yip William C | 2008 | Health Af- fairs2008，27，： | 1 |
| 9 | Hydronephrosis index:A better physiological reference in antenatal ultrasound for assessment of fetal hydronephrosis显示文摘 | Yee V Leung M Winnie C | 2008 | J Pediatr2008，6，： | 1 |
| 10 | Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes 显示文摘 | RAYMOND H S WINNIE W S ALEX H C | 1992 | Infection and Immunity1992，60，7： | 1 |
| 11 | The incidence of deepvein thrombosis in women undergoing cesarean delivery显示文摘 | Winnie W S Raymond O P Ann B C | 2009 | ThrombosisResearch2009，123，3： | 1 |
| 12 | Tunneling or propping:evidence from connected transactions in Chi-na显示文摘 | Winnie Q P Wei K C Yang Z | | 0，，2： | 1 |
| 13 | Early appraisal of China' s huge and complex health-care reforms显示文摘 | Winnie C M Y William C H Wen C | 2012 | The Lancet2012，379，9818： | 1 |
| 14 | Targeting GRB7/ERK/FOXM1 signaling pathway impairs aggressiveness of ovarian cancer cells 显示文摘 | David W C Winnie W Y Patty C H | 2012 | PLoS One2012，7，12： | 1 |
| 15 | Physician response to Medicare fee reductions: changes in the volume of coronary artery bypass graft (CABG) surgeries in the Medicare and private sectors 显示文摘 | Winnie C Y | 1998 | Journal of Health Economics1998，，17： | 1 |
| 16 | Anxiety, depression and quality of life among Chinese breast cancer patients during adjuvant therapy 显示文摘 | Winnie KW Marsh C Ling WM | 2010 | Eur Jorcol Nurs2010，14，1： | 1 |
| 17 | Invasion of v-Fos(FBR) -transformed cells is dependent upon histone deacetylaseactivity and suppression of histone deacetylase regulated genes显示文摘 | McGarry L C Winnie J N Ozanne B W | 2004 | Oncogene2004，23，31： | 1 |
| 18 | Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab 显示文摘 | Winnie Yeo Tung C Chan Nancy W Y Leung | 2009 | Journal of Clinical Oncology2009，27，4： | 1 |
| 19 | Early appraisal of China's huge and complex healthcare reforms显示文摘 | Winnie Chi-Man Yip William C Hsiao Wen Chen | | 0，，： | 1 |
| 20 | Success or Failure : Selectivity and Reasons of Return Migration in Sichuan and Anhui, China显示文摘 | Wenfei Winnie Wang C Cindy Fan | 2006 | Environment and Planning2006，，38： | 1 |
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