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| 1 | Effect of precut sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis:A systematic review and meta-analysis显示文摘AIM:To conduct a systemic review and meta-analysis to investigate the role of early precut technique.Multiple randomized controlled trails(RCTs)have reported conflicting results of the early precut sphincterotomy.METHODS:MEDLINE/PubMed,EMBASE,Cochrane Central Register of Controlled Trials and Database of Systematic Reviews,and recent abstracts from major conference proceedings were searched(June 2013).Randomized and non-randomized studies comparing early precut technique with prolonged standard methods were included.Pooled estimates of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP),cannulation and adverse events were analyzed by using odds ratio(OR).Random and fixed effects models were used as appropriate.Publication bias was assessed by funnel plots.Heterogeneity among studies was assessed by calculating I2 measure of inconsistency.RESULTS:Seven randomized and seven non-randomized trials met inclusion criteria.Meta-analysis of RCTs showed a decrease trend for PEP with early precut sphincterotomy but was not statistically significant(OR=0.58;95%CI:0.32-1.05;P=0.07).No heterogeneity was noted among the studies with I2 of 0%.CONCLUSION:Early precut technique for common bile duct cannulation decreases the trend of post-ERCP pancreatitis. | Abhishek Choudhary Jessica Winn Sameer Siddique Murtaza Arif Zainab Arif Ghassan M Hammoud Srinivas R Puli Jamal A Ibdah Matthew L Bechtold | 2014 | World Journal of Gastroenterology2014，20，14： | 13 |
| 2 | Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody显示文摘AIM To investigate near-infrared photoimmunotherapeutic effect mediated by an anti-tissue factor(TF) antibody conjugated to indocyanine green(ICG) in a pancreatic cancer model.METHODS Near-infrared photoimmunotherapy(NIR-PIT) is a highly selective tumor treatment that utilizes an antibody-photosensitizer conjugate administration, followed by NIR light exposure. Anti-TF antibody 1849-ICG conjugate was synthesized by labeling of rat IgG2 b anti-TF monoclonal antibody 1849(anti-TF 1849) to a NIR photosensitizer,ICG. The expression levels of TF in two human pancreatic cancer cell lines were examined by western blotting. Specific binding of the 1849-ICG to TF-expressing BxPC-3 cells was examined by fluorescence microscopy. NIR-PITinduced cell death was determined by cell viability imaging assay. In vivo longitudinal fluorescence imaging was used to explore the accumulation of 1849-ICG conjugate in xenograft tumors. To examine the effect of NIRPIT, tumor-bearing mice were separated into 5 groups:(1) 100 μg of 1849-ICG i.v. administration followed by NIR light exposure(50 J/cm2) on two consecutive days(Days 1 and 2);(2) NIR light exposure(50 J/cm2) only on two consecutive days(Days 1 and 2);(3) 100 μg of 1849-ICG i.v. administration;(4) 100 μg of unlabeled antiTF 1849 i.v. administration; and(5) the untreated control. Semiweekly tumor volume measurements, accompanied with histological and immunohistochemical(IHC) analyses of tumors, were performed 3 d after the 2nd irradiation with NIR light to monitor the effect of treatments. RESULTS High TF expression in BxPC-3 cells was observed via western blot analysis, concordant with the observed preferential binding with intracellular localization of 1849-ICG via fluorescence microscopy. NIR-PIT-induced cell death was observed by performing cell viability imaging assay. In contrast to the other test groups, tumor growth was significantly inhibited by NIR-PIT with a statistically significant difference in relative tumor volumes for 27 d after the treatment start date [2.83 ± 0.38(NIR-PIT) vs 5.42 ± 1.61(Untreated), vs 4.90 ± 0.87(NIR), vs 4.28 ±1.87(1849-ICG), vs 4.35 ± 1.42(anti-TF 1849), at Day 27, P < 0.05]. Tumors that received NIR-PIT showed evidence of necrotic cell death-associated features upon hematoxylin-eosin staining accompanied by a decrease in Ki-67-positive cells(a cell proliferation marker) by IHC examination.CONCLUSION The TF-targeted NIR-PIT with the 1849-ICG conjugate can potentially open a new platform for treatment of TF-expressing pancreatic cancer. | Winn Aung Atsushi B Tsuji Aya Sugyo Hiroki Takashima Masahiro Yasunaga Yasuhiro Matsumura Tatsuya Higashi | 2018 | World Journal of Gastroenterology2018，24，48： | 7 |
| 3 | Dedifferentiated liposarcoma arising from the sigmoid mesocolon: A case report显示文摘Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. It occurs most commonly in the retroperitoneum and rarely in other anatomic locations. In the present report, we describe a case of dedifferentiated liposarcoma that occurred in an unusual location, sigmoid mesocolon, which has not yet been documented. | Brody Winn John Gao Homayoon Akbari Baishali Bhattacharya | 2007 | World Journal of Gastroenterology2007，13，30： | 5 |
| 4 | Sonoelastography in the musculoskeletal system:Current role and future directions显示文摘Ultrasound is an essential modality within musculoskeletal imaging, with the recent addition of elastography. The elastic properties of tissues are different from the acoustic impedance used to create B mode imaging and the flow properties used within Doppler imaging, hence elastography provides a different form of tissue assessment. The current role of ultrasound elastography in the musculoskeletal system will be reviewed, in particular with reference to muscles, tendons, ligaments, joints and soft tissue tumours. The different ultrasound elastography methods currently available will be described, in particular strain elastography and shear wave elastography. Future directions of ultrasound elastography in the musculoskeletal system will also be discussed. | Naomi Winn Radhesh Lalam Victor Cassar-Pullicino | 2016 | World Journal of Radiology2016，8，11： | 5 |
| 5 | Investigations on longwall mining subsidence impacts on Pennsylvania highway alignments显示文摘Over 600 longwall panels have been mined in Pennsylvania in the last 50 years. Of those 600 panels, 25 panels undermined interstates highways. Despite this quantity of panels, much is still unknown regarded the detailed effects of undermining highways. The Gateway Mine, the Emerald Mine, and the Cumberland Mine undermined I-79 with 17 panels in 1982–1989 and in 2003–2008, respectively;Mine 84 undermined I-70 with 4 panels in 1987–2000. Through the examination of the panels that undermined I-70 and I-79, it is possible to determine which factors have most impacted the highway alignments. In some locations, the highway intersects with panels at angles ranging from 45° to 80°;and at the others, it runs between two panels, which simulates the effect of gateroads on the subsidence. The panel width to overburden ratio varies between 0.64 and 1.7, meaning that the interstates were influenced by both subcritical and supercritical subsidence basins. The face advance rates and overburden depths also vary between the panels. Unfortunately, specific information detailing highway impacts associated with unique characteristics of the subsidence basins are limited. In this paper, using the profile function model and influence function model within the surface deformation prediction system(SDPS), the effects of overburden,panel size, and orientation of the road on the highway can be indirectly assessed. | Emily Adelsohn Anthony Iannacchione Robert Winn | 2020 | International Journal of Mining Science and Technology2020，30，1： | 2 |
| 6 | The Pascal Visual Object Classes (VOC) Challenge显示文摘 | Mark Everingham Luc Gool Christopher K. I. Williams John Winn Andrew Zisserman | 2010 | International Journal of Computer Vision2010，，2： | 2 |
| 7 | A dielectric omnidirectional reflector显示文摘 | Fink Y Winn J N Fan S | 1998 | Science1998，282，5394： | 2 |
| 8 | Omnidirectional reflection from a one-dimentional photonic crystal 显示文摘 | Fink Y Winn J N Fan S | 1998 | Opt Lett1998，23，20： | 2 |
| 9 | A dielectric omnidirectional reflector显示文摘 | Fink Y Winn J N Fan S | 1998 | Science1998，282，： | 1 |
| 10 | Hyperglycemia and neurological outcome in patient with head injury显示文摘 | Winn HR Cullen BF | 1991 | Neurosurg1991，75，： | 1 |
| 11 | A mutation in the TRPC6cation channel causes familial focal segmnental glomerulosclerosis显示文摘 | Winn MP Conlon PJ Lynn KL | 2005 | Science2005，308，5729： | 1 |
| 12 | Three portmicro laparoscopic cholecystectomy in 159 patients显示文摘 | Leggett PL Bissell CD Churchman Winn R | 2001 | SurgEndosc2001，15，2： | 1 |
| 13 | Fabrication of poly ( alpha-hydroxy acid) foam scaffolds using multiple solvent systems 显示文摘 | Hu Y Grainger D W Winn S R | 2002 | J Biomed Mater Res2002，59，3： | 1 |
| 14 | Surgical resection ofepileptogenic cortex associated with structural lesion 显示文摘 | Weber JP Silbergeld DL Winn HR | 1993 | Neurosurg Clin N Am1993，4，2： | 1 |
| 15 | Interrelationships between hu-man capital,HRM and innovation in Belgian start - ups aiming at aninnovation strategy 显示文摘 | DE WINNE SOPHIE LUC SELS | 2010 | International Journal of Human ResourceManagement2010，9，21： | 1 |
| 16 | Evidence for genetic factors in the development and progression of IgA nephropathy显示文摘 | Hsu SI Ramirez SB Winn MP | 2000 | Kidney Int2000，57，5： | 1 |
| 17 | Phase Ⅱ study of taxol in patients with untreated advanced non-small lung cancer显示文摘 | Fossella FV Winn RJ | 1993 | J Natl Cancer Inst1993，85，： | 1 |
| 18 | Insulin-like growth factor iso- forms in skeletalmuscle aging, regeneration,and disease显示文摘 | Winn N PaulA Musaro A | 2002 | Cold Spring Harb Syrup Quant Biol2002，67，： | 1 |
| 19 | TRPC6 and FSGS: the lat- est TRP channelopathy 显示文摘 | Mukerji N Damodaran TV Winn MP | 2007 | Biochim Biophys Acta2007，1772，： | 1 |
| 20 | Smoking and drinking in relation to oral and pharyngeal cancer 显示文摘 | Blot WJ McLaughlin JK Winn DM | 1988 | Cancer Resesrch1988，48，： | 1 |
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