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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | 应用高压水射流作为一种高效率的磨煤工具显示文摘 | Mazurkiewicz M Summers D A | 1986 | 高压水射流1986，，2： | 2 |
| 3 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 4 | Positive Feedback Investment Strategies and Destabilizing Rational Speculation显示文摘 | DE LONG J B SHLEIFER A SUMMERS L H | 1990 | Journal of Finance1990，45，6： | 1 |
| 5 | Mesenchymal progenitor cell research: limitations and recommendations显示文摘 | Summer R Fine A | 2008 | Proc Am Thorac Soc2008，5，6： | 1 |
| 6 | Trends in the development of baculovirus expression vectors显示文摘 | Luekow V A Summers M D | 1988 | Biotechnology1988，6，： | 1 |
| 7 | Diagenesis and preservation of porosity in Norphlet Formation (Upper Jurassic), southern Alabama显示文摘 | DIXON S A SUMMERS D M SURDAM R C | 1989 | Am Assoc Pet Geol Bull1989，73，： | 1 |
| 8 | Phytoremediation of meth-ylmercury pollution:merB expression in Arabidopsis thaliana confers resistance to organomercurials显示文摘 | BIZILY S P PUGH C L SUMMERS A O | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 9 | Measured impedanceof vertical antennas over finite ground planes 显示文摘 | MEIER A S SUMMERS W P | 1949 | Proc IEEE1949，37，6： | 1 |
| 10 | Scale dependence of hypsometric integrals:An analysis of southeast African hasin显示文摘 | Waleott R C Summer? eld M A | 2008 | Geomorphology2008，96，17： | 1 |
| 11 | Earlyeventsin canine distemper demyelinating encephalomyelitis显示文摘 | SUMMERS B A GREISEN H A APPEL M J G | 1979 | Acta Neuropathologica1979，52，： | 1 |
| 12 | Performance on trials without knowledge of results (KR) in reduced relative frequency presentations of KR显示文摘 | Sparrow W A Summers J J | 1992 | Journal of Motor Behavior1992，，24： | 1 |
| 13 | Experimental investigation on the breakage of hard rock by the PDC cutters with combined action modes 显示文摘 | LI Xi -bing Summers D A Rupert G | 2001 | Tunnelling and Underground Space Technology2001，16，： | 1 |
| 14 | Protein and fat composition of mare's milk:Some nutritional remarks with reference to human and cow's milk显示文摘 | Malacarne M Martuzzi F Summer A | 2002 | International Dairy Journal2002，，12： | 1 |
| 15 | Pathogenicity of morbiliviruses for terresttial carnivores显示文摘 | Appel M J G Summer B A | 1995 | Vet Microbiol1995，44，： | 1 |
| 16 | Diagenesis and prservation of porosity in Norphlet Formation( Upper Jurassic) , southern Alabama 显示文摘 | DIXON S A SUMMERS D M SURDAM R C | 1989 | Am Assoc Petrol Geol Bull1989，73，6： | 1 |
| 17 | Cell fusion-independent differentiation of neural stem cells to the endothelial lineage显示文摘 | Nakashima K Summers RG | 2004 | Nature2004，430，6997： | 1 |
| 18 | Diagenesis and prservation of porosity in Norphlet Formation(Upper Jurassic),southern Alabama显示文摘 | Dixon S A Summers D M Surdam R C | 1989 | American Association of Petroleum Geologists Bulletin1989，73，6： | 1 |
| 19 | Structm and evolutionary implication of a'cysteine-rich'Campoletis sonorensis polydnavirus gene family Proc显示文摘 | Dib-Hajj S D Webb B A Summer M D | 1993 | Natl Acad Sci1993，90，： | 1 |
| 20 | Hyperinsulinism and sex hormones in young adult African Americans显示文摘 | Falkner B Sherif K Summer A | 1999 | Metabolism1999，48，1： | 1 |
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