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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | The soil-freezing method for large tunnel construction显示文摘 | Wind H | 1979 | Engineering Geol1979，，13： | 1 |
| 3 | Computer Enhanced Separation of Compound Classes in Fuel Mixtures Using a Combined LC-MS Approach显示文摘 | Hoesterey B L McClennen W H Winding W | 1985 | Amer Chem Soc Div Fuel Chem Prepr1985，30，1： | 1 |
| 4 | Efficient whole-cell biotransformation of 5-(hydroxymethyl)furfural into FDCA, 2,5-furandicarboxylic acid 显示文摘 | KOOPMAN F WIERCKX N DE WINDE J H | 2010 | Bioresource Technology2010，101，16： | 1 |
| 5 | The impact of cross reactivity of anti-HLA-B27 monoclonal antibodies on flow cytometric HLA-B27 screening显示文摘 | Levering H Wind K Sintnicolaas | 2002 | Human Immunology2002，63，10： | 1 |
| 6 | Synthetic matrixmetalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice 显示文摘 | Winding B NicAmhlaoibh R Misander H | 2002 | Clin Cancer Res2002，8，6： | 1 |
| 7 | Systematic review of enhanced recovery programmes in colonic surgery显示文摘 | WIND J POLLE S W FUNG KONJIN P H | 2006 | Br J Surg2006，93，7： | 1 |
| 8 | Design and application of decision support systems for integrated water management:lessons to be learnt显示文摘 | de Kok J L Wind H G | 2003 | Physics and Chemistry of the Earth2003，28，： | 1 |
| 9 | Flow cytometric HLA-B27 screening : cross-reactivity patterns of commercially available anti-HLA-B27 monoclonal antibodies with other HLA-B antigens显示文摘 | Levering WH Wind H Sintnicolaas K | 2003 | Cytometry2003，54，1： | 1 |
| 10 | Flow cytometric HLA-B27 screening:cross-reactivity patterns of commercially available anti-HLA-B27 monoclonal antibodies with other HLA-B antigens显示文摘 | Levering WH Wind H Sintnicolaas K | 2003 | Cytometry B Clin Cytom2003，54，1： | 1 |
| 11 | Overcoming environmental dose rate changes in luminescence dating of waterlain deposits 显示文摘 | Li B Li S H Winde A G | 2008 | Geochronometria2008，30，： | 1 |
| 12 | Effect of functional capacity evaluation information on the judgment of physicians about physical work ability in the context of disability claims显示文摘 | Wind H Gouttebarge V Kuijer PPFM | 2009 | International archives of occupational and environmental health2009，82，9： | 1 |
| 13 | Surgical cure for early rectal carcinomas (T1)显示文摘 | Winde G Nottberg H Keller R | | 0，，09： | 1 |
| 14 | DataWare: sea clutter and small boat radar reflectivity databases 显示文摘 | WIND H J CILLIERS J E HERSEI34AN P L | 2010 | IEEE Signal Processing Magazine2010，，： | 1 |
| 15 | Efficient whole-cell biotransformation of 5-(hydroxymethyl) furfural into FDCA, 2, 5-furandicarboxylic acid显示文摘 | Koopman F Wierckx N de Winde J H | 2010 | Bioresource Technology2010，101，16： | 1 |
| 16 | Physiological and genomewide transcriptional responses of Saccharomyces cerevisiae to high carbon dioxide concentrations 显示文摘 | Aguilera J Petit T De Winde J H et ol | 2005 | FEMs Yeast Research2005，，67： | 1 |
| 17 | Systematic review of enhanced recovery programmes in colonic surgery 显示文摘 | Wind J Polle S W Fung Kon Jin P H | 2006 | Br J Surg2006，93，7： | 1 |
| 18 | Flow cytometric HLA-B27 screening: cross-reactivity patterns of commercially available anti-HLA-B27 monoclonal antibodies with other HLA-B antigens显示文摘 | Levering WH Wind H Sintnicolaas K | 2003 | Cytometry2003，54，1： | 1 |
| 19 | The will and the way, Sports Illustrated显示文摘 | Wind H | 1960 | 231960，，3： | 1 |
| 20 | Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae:novel variations of STRE-mediated transcription control?显示文摘 | Winderickx J De Winde J H Crauwels M | 1996 | Mol Gen Genet1996，252，： | 1 |
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