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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | A versatile vector set for animal transgenesis显示文摘 | Horn C Wimmer E A | 2000 | Dev Genes Evol2000，210，： | 1 |
| 3 | Management of postoperative wound infec- tion in posterior spinal fusion with instrumentation 显示文摘 | Wimmer C Gluch H | 1996 | J Spinal Disord1996，9，6： | 1 |
| 4 | Progress in CT imaging for the cardiac surgeon显示文摘 | Herzog C Wimmer Greinecker G Schwarz W | 2004 | Semin Thorac Cardiovasc Surg2004，16，3： | 1 |
| 5 | Translation of poliovirus RNA:role of an essential eis-aeting oligopyrimidine element within the 5 'nontranslated region and involvement of a cellular 57-kilodalton protein显示文摘 | Pestova T V Hellen C U Wimmer E | 1991 | J Virol1991，65，11： | 1 |
| 6 | A versatile vector set for animal trans- genesis 显示文摘 | Horn C Wimmer E A | 2000 | Dev Genes Evoi2000，210，12： | 1 |
| 7 | Numerical simulation of delamination in laminated composite components-A combination of a strength criterion and fracture mechanics显示文摘 | Wimmer G Schuecker C Pettermann H E | 2009 | Composites Part B:Engineering2009，40，2： | 1 |
| 8 | 7-Deoxy-desulfocylindrospermopsin and 7-deoxy-desulfo-12-acetylcylindrospermopsin:Two new cylindrospermopsin analogs isolated from a Thai strain of Cylindrospermopsisraciborskii显示文摘 | Wimmer K M Strangman W K Wright J L C | 2014 | Harmful Algae2014，，20： | 1 |
| 9 | Voltage-dependent Ca2 + channels, not ryanodine receptors, activate Ca2 +-dependent BK potassium channels in human retinal pigment epithelial cells 显示文摘 | Wimmers S Halsband C Seyler S | 2008 | Mol Vis2008，14，： | 1 |
| 10 | Methodology for Prod- uct Service System Innovation显示文摘 | VAN H C CARLO V C WIMMER R | 2005 | Assen: Uitgeverij Van Gor- cum2005，，： | 1 |
| 11 | The Role of Associative Strength in Children' s False Memory Illusions显示文摘 | Howe M L Wimmer M C Blease K | 2009 | Memory2009，11，： | 1 |
| 12 | A versatile vector set for animal transgenesis显示文摘 | Horn C Wimmer EA | 2000 | Dev Genes Evol2000，210，12： | 1 |
| 13 | Management of postoperative wound infec- tion in posterior spinal fusion with instrumentation 显示文摘 | Wimmer C Gluch H | 1996 | J Spinal Discord1996，9，6： | 1 |
| 14 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner MA Arzhaeva Y Aurich V Bauer C Beck A Becket C Beichel R Bekes G Bello F Binnig G Bischof H Bornik A Cashman PM Chi Y Cordova A Dawant BM Fidrich M Furst JD Furukawa D Grenacher L Hornegger J Kainmuller D Kitney RI Kobatake H Lamecker H Lange T Lee J Lennon B Li R Li S Meinzer HP Nemeth G Raicu DS Rau AM van Rikxoort EM Rousson M Rusko L Saddi KA Schmidt G Seghers D Shimizu A Slagmolen P Sorantin E Soza G Susomboon R Waite JM Wimmer A Wolf I | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 15 | An Associative Activation Theory of Children's and Adults' Memory Illusions 显示文摘 | Howe M L Wimmer M C Gagnon N | 2009 | Journal of Memory and Language2009，60，： | 1 |
| 16 | Management of postoperative wound infection in posterior spinal fusion with instrumentation显示文摘 | Wimmer C Gluch H | 1996 | J Spinal Disord1996，9，： | 1 |
| 17 | Management of postoperative wound infection in posterior spinal fusion with instrumentation显示文摘 | Wimmer C Gluch H | 1996 | J Spinal Disord1996，9，6： | 1 |
| 18 | The plant PTS1 receptor:similarities and differences to its human and yeast counterparts显示文摘 | Wimmer C Schmid M Veenhuis M | 1998 | Plant J1998，16，4： | 1 |
| 19 | Genetics of poliovirus显示文摘 | Wimmer E Hellen C U Cao X | 1993 | Annu Rev Gennet1993，27，： | 1 |
| 20 | Associations of func- tional candidate genes derived from gene-expression profiles of prenatal porcine muscle tissue with meat quality and muscle de- position显示文摘 | Wimmers K Murani E Chang K C et ol | 2007 | Anim Genet2007，38，5： | 1 |
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