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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Recent advances in the laboratory detection of Mycobacterium tuberculosis complex and drug resistance 显示文摘 | Wilson ML | 2011 | Clin Infect Dis2011，52，11： | 1 |
| 3 | The corticomotor representation of upper limb muscles in writer's cramp and changes following botulinum toxin injection 显示文摘 | Bymes ML Thickbroom GW Wilson SA | 1998 | Brain1998，121，5： | 1 |
| 4 | Outcomes from mild and moder- ate traumatic brain injuries among children and adolescents:A system- atic review of studies from 2008-2013 显示文摘 | Lloyd J Wilson ML Tenovuo O | 2015 | Brain Inj2015，29，5： | 1 |
| 5 | Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase显示文摘 | Smith MR Wilson ML Hamanaka R | 1997 | Biochem Biophys Res Commun1997，234，2： | 1 |
| 6 | Sorption of PFOA and PFOS to aquifer sediment显示文摘 | Ferrey ML Adair C Wilson JT | 2009 | Reproductive Toxicology2009，27，34： | 1 |
| 7 | Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase显示文摘 | Smith MR Wilson ML Hamanaka R | 1997 | Biochem Biophys Res Commun1997，234，2： | 1 |
| 8 | Herbal and dietary therapies for primary and secondary dysmenorrhoea显示文摘 | Wilson ML Muiphy PA | 2001 | Nurs Times2001，97，36： | 1 |
| 9 | Mycoplasma pneumoniae associated with hemolytic anemia, cold agglutinins, and recurrent arterial thrombosis显示文摘 | Wilson ML Menjivar E Kalapatapu V | 2007 | South Med J2007，100，2： | 1 |
| 10 | Molecular epidemiology of Preeclampsia 显示文摘 | Wilson ML Murphy GT Pan VL | 2002 | Obstet Gynecol Surv2002，58，1： | 1 |
| 11 | The results of the 'Active by Choice Today' (ACT) trial for increasing moderate- to-vigorous physical activity (MVPA) in low-income and minority adolescents 显示文摘 | Wilson DK Van Horn ML Kitzman-Ulrich H | 2011 | Health Psychol2011，30，4： | 1 |
| 12 | Hamsters and guinea Pigs differ in their Plasma lipoprotein cholesterol dis- tribution when fed diets varying in animal Protein, soluble fiber or cholesterol content显示文摘 | Fernandez ML Wilson TA Conde K | 1999 | J Nutr1999，129，7： | 1 |
| 13 | Localisation and regulation of the eIF4E binding protein 4E BP3显示文摘 | Kleijn M Scheper GC Wilson ML | 2002 | FEBS Letters2002，532，3： | 1 |
| 14 | Bact/Alert: an antomated colrimetric micorbial detection system显示文摘 | Thope TC Wilson ML Turner JE | 1990 | J Clin Microbiol1990，28，7： | 1 |
| 15 | Osteopontin inhibits inducible nitric oxide synthase activity in rat vascular tissue 显示文摘 | Scott JA Weir ML Wilson SM | 1998 | Am J Physiol1998，275，11： | 1 |
| 16 | Experience modifies olfactory acuity: acetylcholine-dependent learning decreases behavioral generalization between similar odorants 显示文摘 | FLECHER ML WILSON DA | 2002 | J Neurosci2002，22，： | 1 |
| 17 | Recent advances in the laboratory detection of Mycobacterium tuberculosis complex and drug resistance显示文摘 | Wilson ML | | 0，，11： | 1 |
| 18 | Mycoplasma pneumoniae associated with hemolytic anemia, cold aggln- tinins, and recurrent arterial thrombosis 显示文摘 | Wilson ML Menjivar E Kalapatapu V | 2007 | South Med J2007，100，2： | 1 |
| 19 | Prediction of the physiologic significance of coronary arterial lesions by quantitative lesion geometry in patients with limited coronary artery disease 显示文摘 | Wilson RF Marcus ML White CW | 1987 | Circulation1987，75，4： | 1 |
| 20 | Update on detection of bacte- remia and fungemia显示文摘 | Reimer LG Wilson ML Weinstein MP | 1997 | Clin Microbiol Rev1997，10，： | 1 |
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