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| 1 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 2 | The effects of insulin - like growth factor (IGF) - I , IGF- II, and des-IGF- 1ron neuronal loss after hypoxic - ischemic brain injury in adult rats : evidence for a role for IGF binding proteins 显示文摘 | Guan J Williams CE Skinner SJ | 1996 | Endocrinology1996，137，3： | 1 |
| 3 | Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs显示文摘 | Johnston BM Mallard EC Williams CE | 1996 | Clin Invest1996，97，2： | 1 |
| 4 | Mechanisms of de- layed cell death following hypoxic- ischermia injury in the immature rat:evidence for apoptosis during selective neuronsalloss显示文摘 | Beilharz E J Williams CE Dragunow M | 1995 | Mol Br Res1995，29，1： | 1 |
| 5 | Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs显示文摘 | Mallard EC Williams CE | 1996 | J Clin Invest1996，97，2： | 1 |
| 6 | Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss显示文摘 | Beilharz EJ Williams CE Dragunow M | 1995 | Mol Br Res1995，29，： | 1 |
| 7 | Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-schemic injury in fetal lambs 显示文摘 | JOHNSTON BM MALLARD EC WILLIAMS CE | 1996 | J Clin Invest1996，97，2： | 1 |
| 8 | Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss显示文摘 | Beibarz EJ Williams CE Dragunow M | 1995 | Mol Brain Res1995，29，： | 1 |
| 9 | Maternal periodontal disease and preterm low birthweight: case -control study 显示文摘 | Davenport ES Williams CE Sterne JA | 2002 | J Dent Res2002，81，5： | 1 |
| 10 | A guide to conducting consensual qualitative research 显示文摘 | Hill CE Thompson BJ Williams EN | 1997 | The Counseling Psychologist1997，25，： | 1 |
| 11 | Colon perforation following percutaneous nephrostomy and renal calculus removal显示文摘 | LeRoy AJ Williams HJ Jr Bender CE | 1985 | Radiology1985，155，1： | 1 |
| 12 | Bone marrow disorders:characterization with quantitative MR imaging 显示文摘 | Smith SR Williams CE Davies JM | 1989 | Radiology1989，172，： | 1 |
| 13 | Neuro-protective effects of the N-terminal tripeptide of IGF-1,glycine-proline-glutamate,in the immature rat brain after hypoxic-isehemic injury显示文摘 | Sirimanne ES Williams CE | 2001 | Brain Res2001，922，： | 1 |
| 14 | The effects of insulin-like growth factor IGF-I,IGF-2,and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats:evidence for a role for IGF binding proteins显示文摘 | Williams CE Skinner SJ | 1996 | Endocri-nology1996，137，： | 1 |
| 15 | Neuroprotective effects of Gly-Pto-Glu,the N-terminal tripeptide of IGF-1,in the hippocampus in vitro显示文摘 | Cnratolo L Williams CE | 1999 | Neuroreport1999，10，： | 1 |
| 16 | Quantitative electroen- cephalographic patterns in normal preterm infants over the first week after birth 显示文摘 | West CR Harding JE Williams CE | 2006 | Early Hum Dev2006，82，1： | 1 |
| 17 | The effects of insulin like growth faetor(IGF)-1,IGF-2 and des-1GF-1 on neuroral loss after hypoxic-isehemie brain injury in adult rats:evidence for a role for IGF binding proteins显示文摘 | GUAN J WILLIAMS CE SKINNER S J | 1996 | Endocrinolgy1996，137，3： | 1 |
| 18 | Do bone marrow cells generate neurons? 显示文摘 | David HC William HD James CE | 2004 | Archives of Neurol2004，61，4： | 1 |
| 19 | In-vitro measurement of apically extruded irrigant in primary molars 显示文摘 | Williams CE Reid JS Sharky SW | 1995 | Int Endod J1995，28，4： | 1 |
| 20 | Outcome after ischemia in the developing sheep brain:an electroencephalographic and histological study显示文摘 | Williams CE Gurin AJ Mallard C | 1992 | Ann Neurol1992，31，1： | 1 |
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