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| 1 | Significance of hepatitis virus infection in the oncogenicinitiation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus(HBV) and/or hepatitis C virus(HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC. | Caecilia HC Sukowati Korri E El-Khobar Susan I Ie Beatrice Anfuso David H Muljono Claudio Tiribelli | 2016 | World Journal of Gastroenterology2016，22，4： | 18 |
| 2 | Characterization of multiple-antimicrobial resisitant escherichia coli isolates from diseased chickens and swine in chian显示文摘 | Chen S David GW | 2004 | J Clin Microbiol2004，42，8： | 1 |
| 3 | A wen-Yuh chung gamma knife radiosurgery for central neuroeytoma:retrospeetive analysis of fourteen cases with a median follow-up period of sixty-five 显示文摘 | CHEN MC DAVID PAN HC | 2011 | Months Stereotaet Funet Neurosurg2011，89，3： | 1 |
| 4 | Effect of Early vs Late Tracheostomy Placement on Survival in Patients Receiving Mechanical Ventilation The TracMan Randomized Trial显示文摘 | Duncan Y David AH Brian HC | 2013 | JAMA2013，9，20： | 1 |
| 5 | Interventional spine research:The evolutionof informed consentl 显示文摘 | David AL Larry HC | 2002 | Pain Physician2002，5，1： | 1 |
| 6 | Do bone marrow cells generate neurons? 显示文摘 | David HC William HD James CE | 2004 | Archives of Neurol2004，61，4： | 1 |
| 7 | Characterization of multiple-antimicrobial resisitant Escherichia coli isolated from diseased chickens and swine in China显示文摘 | Yang HC Chen S David GW | 2004 | J Clin Microbiol2004，42，8： | 1 |
| 8 | Cell wall metabolism during maturation,ripening and senescence of peach fruit显示文摘 | DAVID AB VALERIANO DC CARLOS HC | 2004 | Journal of Experimental Botany2004，55，： | 1 |
| 9 | ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult显示文摘 | Sharon AH David WB Marshall HC | 2001 | J Am Coll Cardiol2001，38，7： | 1 |
| 10 | Evidence based guidelines for the secondary prevention of falls in older adults显示文摘 | Julie M Julie R David HC | 2003 | Gerontology2003，49，： | 1 |
| 11 | Characterization of multiple- antimicrobial-resistant Escherichia coli isolates from diseased chickens and swine in china显示文摘 | Yang HC Chen SH David G | 2004 | Journal of clinical microbiology2004，，8： | 1 |
| 12 | Cardiac troponin I measurement with the ACCESS immunoassay system:analytical and clinical performance characteristics显示文摘 | Robert HC Fred SA David LM | 1998 | Clin Chem1998，44，： | 1 |
| 13 | Evidence-based guidelines for the secondary prevention of falls in older adults 显示文摘 | Jutie M Julie R David HC | 2003 | Gerontology2003，49，： | 1 |
| 14 | Treatment with the tumor necrosis factor-inducing drug 5,6-dimethylxanthenone-4-acetic acid enhances the antitumor activity of the photodynamic therapy of RIF-1 mouse tumors显示文摘 | David AB Sandra OG Susan HC | 2003 | Cancer Res2003，63，： | 1 |
| 15 | Patients with coronary artery dis- ease prevalence of extraeranial carotid and vertebral artery diseasein Chinese显示文摘 | Wai HC David S Shu L H | 1998 | Stroke1998，29，： | 1 |
| 16 | An immunophenotypic and molecular study of primary large B-cell lymphoma of bone 显示文摘 | David HC Bernie F Guisheng Y Lim MS | 2001 | Mod Pathol2001，14，10： | 1 |
| 17 | Cryptogenic cirrhosis : clini- cal characterization and risk factor for underlying disease显示文摘 | Stephen HC David HO Julia CI | 1999 | Hep- atology1999，29，： | 1 |
| 18 | Effect of aging on stem cells显示文摘Pluripotent stem cells have the remarkable self-renewal ability and are capable of differentiating into multiple diverse cells. There is increasing evidence that the aging process can have adverse effects on stem cells. As stem cells age, their renewal ability deteriorates and their ability to differentiate into the various cell types is altered. Accordingly, it is suggested aging-induced deterioration of stem cell functions may play a key role in the pathophysiology of the various aging-associated disorders. Understanding the role of the aging process in deterioration of stem cell function is crucial, not only in understanding the pathophysiology of agingassociated disorders, but also in future development of novel effective stem cell-based therapies to treat agingassociated diseases. This review article first focuses on the basis of the various aging disease-related stem cell dysfunction. It then addresses the several concepts on the potential mechanism that causes aging-related stem cell dysfunction. It also briefly discusses the current potential therapies under development for aging-associated stem cell defects. | Abu Shufian Ishtiaq Ahmed Matilda HC Sheng Samiksha Wasnik David J Baylink Kin-Hing William Lau | 2017 | World Journal of Experimental Medicine2017，7，1： | 1 |
| 19 | 主观理性视角:原位与在体可持续性供应链管理显示文摘文章旨在为可持续性供应链管理提供一个新的理论视角,即主观理性视角(SRP,the subjective rationality perspective)。不同企业对是什么构成了“更美好的世界”具有自己主观的和规范的信念。SRP将可持续性本身视为一种主观性和规范性的追求,将可持续性供应链管理视为在供应链层面上实施企业信念的行为。在实践中,由于独立运营的企业对现代可持续性的构成持有不同的信念和优先顺序,而供应链中的企业又是相互依存的,因此,采用SRP可使得我们就可持续性供应链管理如何在现代实践中发挥作用建立起一个概念模型。SRP的概念视角还阐明了当今企业所面临的两种常见的可持续性供应链管理问题,即SRP I型和SRP II型故障。通过可持续性供应链管理理论,文章对学者和实践者看待和管理供应链可持续性的方式进行了全新的重构;推进了新的可持续性供应链管理结构和术语的文献讨论;为诊断和处理当前供应链可持续性问题提供了新概念工具。 | David HC Correll Alexis Bateman 郭杰群 | 2022 | 供应链管理2022，3，2： | 0 |
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