| 1 | Cardiorespiratory fitness,white blood cell count,and mortality in men and women显示文摘Background:We examined the associations of cardiorespiratory fitness(CRF) and white blood cell count(WBC) with mortality outcomes.Methods: A total of 52,056 apparently healthy adults completed a comprehensive health examination,including a maximal treadmill test and blood chemistry analyses.CRF was categorized as high,moderate,or low by age and sex;WBC was categorized as sex-specific quartiles.Results:During 17.8± 9.5 years(mean± SD) of follow-up,a total of 4088 deaths occurred.When regressed jointly,significantly decreased allcause mortality across CRF categories was observed within each quartile of WBC in men.Within WBC Quartile 1,all-cause mortality hazard ratios(HRs) with a 95% confidence interval(95%CI) were 1.0(referent),1.29(95%CI:1.06-1.57),and 2.03(95%CI:1.42-2.92) for high,moderate,and low CRF categories,respectively(p for trend <0.001).Similar trends were observed in the remaining 3 quartiles.With the exception of cardiovascular disease(CVD) mortality within Quartile 1(p for trend=0.743),there were also similar trends across CRF categories within WBC quartiles in men for both CVD and cancer mortality(p for trend <0.01 for all).For women,there were no significant trends across CRF categories for mortality outcomes within Quartiles 1-3.However,we observed significantly decreased all-cause mortality across CRF categories within WBC Quartile 4(HR=1.05(95%CI:0.76-1.44),HR=1.63(95%CI:1.20-2.21),and HR=1.87(95%CI:1.29-2.69) for high,moderate,and low CRF,respectively(p for trend=0.002)).Similar trends in women were observed for CVD and cancer mortality within WBC Quartile 4 only.Conclusion:There are strong joint associations between CRF,WBC,and all-cause,CVD,and cancer mortality in men;these associations are less consistent in women. | Stephen W.Farrell David Leonard Kerem Shuval Laura F.DeFina Carolyn E.Barlow Andjelka Pavlovic William L.Haskell | 2022 | Journal of Sport and Health Science2022，11，5： | 1 |
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