| 1 | 库珀中心纵向研究:有氧运动的灵魂显示文摘目的:为肯尼斯·库珀(Kenneth H. Cooper)于1970年提出的库珀中心纵向研究(CCLS)提供详细历史。方法:对库珀中心纵向研究人群和库珀诊所所检查的重要参数,以及库珀诊所患者的各种疾病发病率和死亡率进行数据描述。并对近50年来已发表的库珀中心纵向研究的主要研究结果进行总结。结果:在库珀诊所检查期间,通过最大跑台运动测试客观地测量出的心肺功能(CRF)已成为各种疾病发病率和死亡率的强大且独立的风险因素。更具体地说,库珀中心纵向研究明确表明,中高水平的心肺功能与人体全因、心血管疾病和癌症死亡率有显著相关关系。此外,已经证明,中年人群的心肺水平是全因痴呆、Ⅱ型糖尿病、慢性肾病、癌症发病率和存活率以及一些其他慢性疾病的预测因子。因此,库珀中心纵向研究结果还表明,中年人群的心肺水平与老年时期的医疗保健成本呈显著相关。结论:除罕见情况以外,已经进行了近50年的库珀中心纵向研究的研究结果表明,相对于较低水平的心肺功能,中高水平的心肺功能可以有效预防许多疾病。 | Stephen W.Farrell Laura F.DeFina 阎海 朱为模 | 2018 | 体育科研2018，39，6： | 4 |
| 2 | Cardiorespiratory fitness,white blood cell count,and mortality in men and women显示文摘Background:We examined the associations of cardiorespiratory fitness(CRF) and white blood cell count(WBC) with mortality outcomes.Methods: A total of 52,056 apparently healthy adults completed a comprehensive health examination,including a maximal treadmill test and blood chemistry analyses.CRF was categorized as high,moderate,or low by age and sex;WBC was categorized as sex-specific quartiles.Results:During 17.8± 9.5 years(mean± SD) of follow-up,a total of 4088 deaths occurred.When regressed jointly,significantly decreased allcause mortality across CRF categories was observed within each quartile of WBC in men.Within WBC Quartile 1,all-cause mortality hazard ratios(HRs) with a 95% confidence interval(95%CI) were 1.0(referent),1.29(95%CI:1.06-1.57),and 2.03(95%CI:1.42-2.92) for high,moderate,and low CRF categories,respectively(p for trend <0.001).Similar trends were observed in the remaining 3 quartiles.With the exception of cardiovascular disease(CVD) mortality within Quartile 1(p for trend=0.743),there were also similar trends across CRF categories within WBC quartiles in men for both CVD and cancer mortality(p for trend <0.01 for all).For women,there were no significant trends across CRF categories for mortality outcomes within Quartiles 1-3.However,we observed significantly decreased all-cause mortality across CRF categories within WBC Quartile 4(HR=1.05(95%CI:0.76-1.44),HR=1.63(95%CI:1.20-2.21),and HR=1.87(95%CI:1.29-2.69) for high,moderate,and low CRF,respectively(p for trend=0.002)).Similar trends in women were observed for CVD and cancer mortality within WBC Quartile 4 only.Conclusion:There are strong joint associations between CRF,WBC,and all-cause,CVD,and cancer mortality in men;these associations are less consistent in women. | Stephen W.Farrell David Leonard Kerem Shuval Laura F.DeFina Carolyn E.Barlow Andjelka Pavlovic William L.Haskell | 2022 | Journal of Sport and Health Science2022，11，5： | 1 |
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