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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Structural effects on the magnetic hyperthermia properties of iron oxide nanoparticles显示文摘Magnetic iron oxide nanoparticles(IONPs) are heavily explored as diagnostic and therapeutic agents due to their low cost, tunable properties, and biocompatibility. In particular, upon excitation with an alternating current(AC) magnetic field, the NPs generate localized heat that can be exploited for therapeutic hyperthermia treatment of diseased cells or pathogenic microbes. In this review, we focus on how structural changes and inter-particle interactions affect the heating efficiency of iron oxide-based magnetic NPs. Moreover, we present an overview of the different approaches to evaluate the heating performance of IONPs and introduce a new theranostic modality based on magnetic imaging guided–hyperthermia. | Eric C.Abenojar Sameera Wickramasinghe Jesbaniris Bas-Concepcion Anna Cristina S.Samia | 2016 | Progress in Natural Science:Materials International2016，26，5： | 2 |
| 3 | A study of the correlation between dengue and weather in Kandy City, Sri Lanka (2003 -2012) and lessons learned显示文摘Background:Weather variables affect dengue transmission.This study aimed to identify a dengue weather correlation pattern in Kandy,Sri Lanka,compare the results with results of similar studies,and establish ways for better control and prevention of dengue.Method:We collected data on reported dengue cases in Kandy and mid-year population data from 2003 to 2012,and calculated weekly incidences.We obtained daily weather data from two weather stations and converted it into weekly data.We studied correlation patterns between dengue incidence and weather variables using the wavelet time series analysis,and then calculated cross-correlation coefficients to find magnitudes of correlations.Results:We found a positive correlation between dengue incidence and rainfall in millimeters,the number of rainy and wet days,the minimum temperature,and the night and daytime,as well as average,humidity,mostly with a five-to seven-week lag.Additionally,we found correlations between dengue incidence and maximum and average temperatures,hours of sunshine,and wind,with longer lag periods.Dengue incidences showed a negative correlation with wind run.Conclusion:Our results showed that rainfall,temperature,humidity,hours of sunshine,and wind are correlated with local dengue incidence.We have suggested ways to improve dengue management routines and to control it in these times of global warming.We also noticed that the results of dengue weather correlation studies can vary depending on the data analysis. | N D B Ehelepola Kusalika Ariyaratne W M N P Buddhadasa Sunil Ratnayake Malani Wickramasinghe | 2015 | Infectious Diseases of Poverty2015，4，1： | 2 |
| 4 | Intercomparison of Himawari-8 AHI-FSA with MODIS and VIIRS active fire products显示文摘The AHI-FSA(Advanced Himawari Imager-Fire Surveillance Algorithm)is a recently developed algorithm designed to support wildfire surveillance and mapping using the geostationary Himawari-8 satellite.At present,the AHI-FSA algorithm has only been tested on a number of case study fires in Western Australia.Initial results demonstrate potential as a wildfire surveillance algorithm providing high frequency(every 10 minutes),multi-resolution fire-line detections.This paper intercompares AHI-FSA across the Northern Territory of Australia(1.4 million km2)over a ten-day period with the well-established fire products from LEO(Low Earth Orbiting)satellites:MODIS(Moderate Resolution Imaging Spectroradiometer)and VIIRS(Visible Infrared Imaging Radiometer Suite).This paper also discusses the difficulties and solutions when comparing high temporal frequency fire products with existing low temporal resolution LEO satellite products.The results indicate that the multi-resolution approach developed for AHI-FSA is successful in mapping fire activity at 500 m.When compared to the MODIS,daily AHIFSA omission error was only 7%.High temporal frequency data also results in AHI-FSA observing fires,at times,three hours before the MODIS overpass with much-enhanced detail on fire movement. | Chathura Wickramasinghe Luke Wallace Karin Reinke Simon Jones | 2020 | International Journal of Digital Earth2020，13，4： | 2 |
| 5 | Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus显示文摘 | Reginald V.N. Lord Ji Min Park Kumari Wickramasinghe Steven R. DeMeester Stefan Oberg Dennis Salonga Jon Singer Jeffrey H. Peters Kathleen D. Danenberg Tom R. DeMeester Peter V. Danenberg | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，2： | 2 |
| 6 | Produced water treatment by nanofiltration and reverse osmosis mvrabranes 显示文摘 | Mondal S Wickramasinghe S R | 2008 | Joumal of Membrane Science2008，322，1： | 1 |
| 7 | Photo-induced graft polymer- ization of N-isopropyl acrylamide on thin film composite membrane: Produced water treatment and antifouling properties显示文摘 | S Mondal S R Wickramasinghe | 2012 | Separation and Purification Technology2012，90，： | 1 |
| 8 | Modeling sucrose hydrolysis in dilute sulfuric acid solutions at pretreatment conditions for lignocellulosic biomass显示文摘 | Bower S Wickramasinghe R Nagle N J | 2008 | Bioresource Technology2008，99，15： | 1 |
| 9 | Thermally assisted recording beyond traditional limits 显示文摘 | HAMANN H F MARTIN Y C WICKRAMASINGHE H K | 2004 | Ap- pl Phys Let2004，84，： | 1 |
| 10 | Glycosyla-tion of human milk lactoferrin exhibits dynamic changes dur-ing early lactation enhancing its role in pathogenic bacteria-host interactions 显示文摘 | Barboza M Pinzon J Wickramasinghe S | 2012 | Molecular Cellular Proteomics2012，11，6： | 1 |
| 11 | Serum response factor mediates NGF-de- pendent target irmervation by embryonic DRG sensory neurons显示文摘 | Wickramasinghe SR Alvania RS Ramanan N | 2008 | Neuron2008，58，： | 1 |
| 12 | Ribosome depurination assay for ribosome inactivting protein purification 显示文摘 | Wickramasinghe SR Bower SE | 2006 | J Qing Dao Univ (Eng & Technol Ed)2006，21，1： | 1 |
| 13 | SNP discovery in the bovine milk transcriptome using RNA-Seq technology显示文摘 | Angela Cánovas Gonzalo Rincon Alma Islas-Trejo Saumya Wickramasinghe Juan F. Medrano | 2010 | Mammalian Genome2010，，11： | 1 |
| 14 | Diagnosis of megaloblastic nanemias显示文摘 | Wickramasinghe S N | 2006 | Blood Rev2006，20，： | 1 |
| 15 | Type-specific antigenicity of avian reoviruses显示文摘 | Meanger J Wickramasinghe R Enriquez C E | 1995 | Avian Pathol1995，24，： | 1 |
| 16 | De- velopment of near - isogenic lines of wheat carrying different null Wx alleles and their starch properties 显示文摘 | Miura H Wickramasinghe M H A Subasinghe R M | 2002 | Euphytica2002，123，3： | 1 |
| 17 | Photo - induced graft polymerization of N - iso- propyl acrylamide on thin fdm composite membrane Produced water treatment and antifouling properties 显示文摘 | Mondal S Wickramasinghe S R | 2012 | Separation and Purification Technology2012，90，： | 1 |
| 18 | Development of thesmart spring for active vibration control of helicopter blades 显示文摘 | Yong C Zimcik D G Wickramasinghe V K | 2004 | Journal of Intelligent Material Systems and Structures2004，15，1： | 1 |
| 19 | Method for imaging side- walls by atomic forc, e microscopy 显示文摘 | Martin Y Wickramasinghe H K | 1994 | Applied Physics Let- ters1994，64，19： | 1 |
| 20 | Cathepsin B promotes beth motility and invasiveness of oral carcinoma cells显示文摘 | Nagaraj NS Vigneswaran N | 2005 | Arch Biochem Biophys2005，436，1： | 1 |
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