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| 1 | Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis显示文摘AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative colitis.METHODS: The ADAPT study was a prospective, openlabel, multicenter study in pediatric patients with moderate, active ulcerative colitis with pediatric ulcerative colitis activity index(PUCAI) of 35-64. Patients received one weekly apheresis with Adacolumn granulocyte, monocyte/macrophage adsorptive(GMA) apheresis over 5 consecutive weeks, optionally followed by up to 3 additional apheresis treatments over 3 consecutive weeks. The primary endpoint was the change in mean PUCAI between baseline and week 12; the secondary endpoint was improvement in PUCAI categorized as(Significant Improvement, PUCAI decrease of ≥ 35), Moderate Improvement(PUCAI decrease of 20 < 35), Small Improvement(PUCAI decrease of 10 < 20) or No change(PUCAI decrease of < 10). RESULTS: Twenty-five patients(mean age 13.5 years; mean weight 47.7 kg) were enrolled. In the intention-to-treat set(ITT), the mean value for PUCAI improvement was 22.3 [95%CI: 12.9-31.6; n = 21]. In the per-protocol(PP) set, the mean improvement was 36.3 [95%CI: 31.4-41.1; n = 8]. Significant Improvement was recorded for 9 out of 20 patients(45%); 5 out of 20 patients(25%) had Moderate Improvement and one patient(5%) had No Change in PUCAI score at week 12. In the PP set, six out of eight patients(75%) showed Significant Improvement; and in two out of eight patients(25%) Moderate Improvement was recorded. The endoscopic activity index(EAI) decreased by 3 points on average. Seven(7) out of 21(33%) patients in ITT and 4 out of 8(50%) patients in PP have used steroids during the clinical investigation. The mean steroid dosage for these patients in the ITT set decreased from a mean 12.4 mg to 10 mg daily on average from Baseline to week 12.CONCLUSION: Adacolumn; GMA apheresis treatment was effective in pediatric patients with moderate active Ulcerative Colitis. No new safety signals were reported. The present data contribute to considering GMA apheresis as a therapeutic option in pediatric patients having failed first line therapy. | Tarja Ruuska Peter Küster Lena Grahnquist Fredrik Lindgren Anne Vibeke Wewer | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 2 | Environmental factors and risk of developing paediatric inflammatory bowel disease — A population based study 2007–2009显示文摘 | Christian Jakobsen Anders Paerregaard Pia Munkholm Vibeke Wewer | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 3 | Gallstones in children显示文摘 | WEWER AV HOVENDAL CP PAERREGAARD A | 2005 | Ugeskr Laeger2005，167，24： | 1 |
| 4 | A critical review of visual analogue scales in the measurement of clinical phenomena显示文摘 | Wewers ME Lowe NK | 1990 | Res Nurs Health1990，13，4： | 1 |
| 5 | Infliximab Dependency in a National Cohort of Children with Crohn?s Disease显示文摘 | Vibeke Wewer Lene Riis Ida Vind Steffen Husby Pia Munkholm Anders Paerregaard | 2006 | Journal of Pediatric Gastroenterology and Nutrition2006，，1： | 1 |
| 6 | A critical review of visual analogue scales in the measurement of clinical phenomena显示文摘 | Wewers ME Lowe NK | | 0，，04： | 1 |
| 7 | A critical review of visual analogue scales in the measurement ol clinical phenomena显示文摘 | Wewers ME Lowe NK | 1990 | Res Nurs Health1990，13，4： | 1 |
| 8 | Gallstones in children 显示文摘 | Wewer AV Hovendal CP Paerre-gaard A | 2005 | Ug-eskr Laeger2005，167，： | 1 |
| 9 | Regulation of monocyte apoptosis by the protein kinase Cdelta-depend- ent phosphorylation of caspase-3 显示文摘 | Voss O H Kim S Wewers M D | 2005 | J Biol Chem2005，280，17： | 1 |
| 10 | Different Patterns of Helicobacter pylori Adherence to Gastric Mucosa Cells in Children and Adults: An Ultrastructural Study显示文摘 | J. Blom A. Gernow S. Holck V. Wewer A. N?rgaard L. B. Graff P. A. Krasilnikoff L. P. Andersen S. O. Larsen | 2000 | Scandinavian Journal of Gastroenterology2000，，10： | 1 |
| 11 | Regulation of ROCK activity in cancer显示文摘 | Morgan-Fisher M Wewer U M Yoneda A | 2013 | J Histochem Cytochem2013，61，18： | 1 |
| 12 | A critical review of visual analogue scales in the measurement of clinical phenomena显示文摘 | Wewers ME Lowe NK | 1990 | Res Nurs Health1990，13，4： | 1 |
| 13 | A critical review of visual analogue scales in the measurement of clinical phenomena显示文摘 | Wewers ME Lowe NK | 1990 | Research in Nursing and Health1990，13，3： | 1 |
| 14 | A critical review of visual analogue scales in the measurement of clinical phenomena显示文摘 | Wewers M E Lowe N K | 1990 | Res Nurs Health1990，13，4： | 1 |
| 15 | Gallstones in children显示文摘 | Wewer AV HovendaI CP Paerregaard A | 2005 | Ugeskr Laeger2005，167，24： | 1 |
| 16 | Gallstones in children显示文摘 | Wewer AV Hovendal CP Paertegaad A | 2005 | Ugeskr Laeger2005，167，24： | 1 |
| 17 | Gallstones in children 显示文摘 | Wewer AV Hovendal CP Paerregaard A | 2005 | Ugeskr Laeger2005，167，24： | 1 |
| 18 | Development of an abrasion re-sistant steel composite with in situ TiC partides显示文摘 | Birgit Wewers | 2001 | Wear2001，251，： | 1 |
| 19 | ADAM12 in human liver cancers:TGF-beta-regulated expression in stellate cells is associated with matrix remodeling显示文摘 | Le Pabic H Bonnier D Wewer U M | 2003 | Hepatology2003，37，5： | 1 |
| 20 | ADAM12 in human liver cancers:TGF-beta-regulated expression in stellate cells is associated with matrix remodeling显示文摘 | Le Pabic H Bonnier D Wewer U M | 2003 | Hepatology2003，37，5： | 1 |
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