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| 1 | Strong modulation of two-photon excited fluorescence of quadripolar dyes by (De) protonation显示文摘 | Werts M H V Gmouh S Mongin O | 2004 | J Am Chem Soc (Communication)2004，126，16： | 1 |
| 2 | Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy显示文摘Diabetic retinopathy(DR)affects approximately one-third of diabetic patients and,if left untreated,progresses to proliferative DR(PDR)with associated vitreous hemorrhage,retinal detachment,iris neovascularization,glaucoma and irreversible blindness.In vitreous samples of human patients with PDR,we found elevated levels of hypoxia inducible factor 1 alpha(HIF1α).HIFs are transcription factors that promote hypoxia adaptation and have important functional roles in a wide range of ischemic and inflammatory diseases.To recreate the human PDR phenotype for a preclinical animal model,we generated a mouse with neuroretinal-specific loss of the von Hippel Lindau tumor suppressor protein,a protein that targets HIF1αfor ubiquitination.We found that the neuroretinal cells in these mice overexpressed HIF1αand developed severe,irreversible ischemic retinopathy that has features of human PDR.Rapid progression of retinopathy in these mutant mice should facilitate the evaluation of therapeutic agents for ischemic and inflammatory blinding disorders.In addition,this model system can be used to manipulate the modulation of the hypoxia signaling pathways,for the treatment of non-ocular ischemic and inflammatory disorders. | Katherine J Wert Vinit B Mahajan Lijuan Zhang Yuanqing Yan Yao Li Joaquin Tosi Chun Wei Hsu Takayuki Nagasaki Kerstin M Janisch Maria B Grant MaryAnn Mahajan Alexander G Bassuk Stephen H Tsang | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 1 |
| 3 | Inereased metalloProteinase activity oxidant Production, and emphysema in surfactant Protein D gene-inaetivated mice 显示文摘 | Wert SE Yoshida M LeVine AM | 2000 | Proe Natl Acad Sci USA2000，，97： | 1 |
| 4 | Audiometric outcomes for acoustic neuroma patients after single versus multiple fraction stereotactic irradiation显示文摘 | McWilliams W Trombetta M Werts ED | | 0，，02： | 1 |
| 5 | Angular dependence of single event sensitivity in hardened flip/flop designs显示文摘 | BAZE M P HUGHLOCK B WERT J | | 0，，06： | 1 |
| 6 | Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice显示文摘 | WERT S E NOGEE L M | 2003 | J Biol Chem2003，278，52： | 1 |
| 7 | Heavy ion, high-energy, and low-energy proton SEE sensitivity of 90 nm RHBD SRAMs显示文摘 | CANNON E H CABANASHOLMEN M WERT J | 2010 | IEEE Trans Nucl Sci2010，57，6： | 1 |
| 8 | Deletion of scap in alveolar type Ⅱ cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipoflbroblasts显示文摘 | Besnard V Wert S E Stahlman M T | 2009 | J Biol Chem2009，284，6： | 1 |
| 9 | Allelic heterogeneity in hereditary surfactant protein B (SP-B) deficiency显示文摘 | NOGEE L M WERT S E PROFFIT S A | 2000 | Am J Respir Crit Care Med2000，161，31： | 1 |
| 10 | Investigating so- lidification with the laser- engineered net shaping ( LENSTM ) process显示文摘 | Hofmeister W Wert M Smugeresky J | 1999 | JOM1999，51，7： | 1 |
| 11 | Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice显示文摘 | Wert SE Yoshida M Levine AM | | 0，，： | 1 |
| 12 | Modeling creep deformation of a two-phase TiAl/Ti3 Al alloy with a lamellar microstructure显示文摘 | WERT J A | 1994 | Metall Mater Trans1994，25，6： | 1 |
| 13 | Modelling of continuous recrystaUization in aluminium alloys 显示文摘 | LYTTLE M T WERT J A | 1994 | Journal of Materials Science1994，29，12： | 1 |
| 14 | Strong modulation of two-photon excited fluorescence of quadripolar dyes by (de)protonation显示文摘 | Werts M H V Gmouh S Mongin O | 2004 | J Am Chem Soc (Communication)2004，126，16： | 1 |
| 15 | Lung Kruppel-like factor, a zinc finger transcription factor, is essential for normal tung development 显示文摘 | Wani M A Wert S E Lingrel J B | 1999 | J Biol Chem1999，274，21： | 1 |
| 16 | Low Target Prevalence is a Stubborn Source of Errors in Visual Search Tasks 显示文摘 | Wolfe J M Horowitz T S Van Wert M J | 2007 | Journal of Experimental Psychology: General2007，136，4： | 1 |
| 17 | Precipitate-induced Plastic Anisotropy:Explicit Solution of the Plastic Anisotropy due to Plate-shaped Precipitates显示文摘 | Lyttle M T Wert J A | 1999 | Metallurgcal and Materials Transactions1999，，30： | 1 |
| 18 | Investigation of solidification in the laser engineered net shaping (LENSTM) process显示文摘 | HOFMEISTER W WERT M SMUGERESKY J | 1999 | JOM1999，51，7： | 1 |
| 19 | Beta-catenin regulates differentiation of respiratory epithelial cells in vivo显示文摘 | Mucenski M L Nation J M Thitoff A R Besnard V Xu Y Wert S E | 2005 | Am J Physiol Lung Cell Mol Physiol2005，289，： | 1 |
| 20 | Adsorption of bacteriophage lambda on the LamB protein of Escherichia coli K-12:point mutations in gene J of lambda responsible for extended host range显示文摘 | WERTS C MICHEL V HOFNUNG M | 1994 | J Bacteriol1994，176，4： | 1 |
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