|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | 孤儿受体-雌激素受体相关受体(ERRs)在雌激素信号途径中的研究进展显示文摘 | 孙蓬明 Jalied Sehouli Werne rlitchnegger 魏丽惠 | 2006 | 中国妇产科临床杂志2006，7，1： | 2 |
| 3 | Crenarchaeotal lipids in lake sediments: A new paleotemperature proxy for continental paleoclimate reconstruction? 显示文摘 | Powers L A Werne J P Johnson T C | 2004 | Geology2004，32，： | 1 |
| 4 | Can positive employees help positive organizational change impact of psychological capital and emotions on relevant attitudes and behaviors 显示文摘 | Avey JB Werning TS Luthans F | 2008 | J Applied Behav Sci2008，44，1： | 1 |
| 5 | Procalcitonin for guidance of antibiotic therapy显示文摘 | Philipp Schuetz Werne Albrich Mirjam Christ-Crain | 2010 | Exp Rev Anti-infect Ther2010，8，5： | 1 |
| 6 | Management of T1-T2 glottic carcinomas显示文摘 | Mendenhall W M Werning J W Hinerman R W | 2004 | Cancer2004，100，9： | 1 |
| 7 | Elective management ofthe clinically negative neck by otolaryngologists in patients with o2ral tongue cancer显示文摘 | Werning JW Heard D Pagano C | 2003 | Arch Otolaryngol Head Neck Surg2003，129，1： | 1 |
| 8 | Local search heuristics for two-stage flow shopproblems with secondary criterion显示文摘 | Guptaind H K Werne F | 2002 | Computer & Operations Research2002，29，2： | 1 |
| 9 | Influence of Measurement and Evaluation Parameters on Stress Distributions Investigated by X -rays 显示文摘 | WERN H | 1991 | Strain1991，27，11： | 1 |
| 10 | Localizing and segmenting text in images and videos显示文摘 | LIENHART R WERN/CKE A | 2002 | IEEE Transactions on Circuits and Systems for Video Technology2002，12，4： | 1 |
| 11 | Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin显示文摘 | Hanna J Werning M Markoulaki S | 2007 | Science2007，318，5858： | 1 |
| 12 | Adenoid cystic carcinoma of the head and neck显示文摘 | Balamucki CJ Amdur RJ Werning JW | 2012 | Am J Otolaryn- gol2012，33，5： | 1 |
| 13 | In vitro differentiation of transplantable neural precursors from human embryonic stem cells 显示文摘 | Zhang S C Werning M Duncan I D | 2001 | Nat Biotechnol2001，19，12： | 1 |
| 14 | Quantification of via-ble Escherichia coli 0157 : H7 in meat products by duplex real-timePCR assays 显示文摘 | Gordillo R Rodriguez A 'Werning ML | 2014 | Meat Sci2014，962，： | 1 |
| 15 | Dual-Band Planar Inverted F Antenna for GSM/DCS Mobile Phones 显示文摘 | YEH Shih Huang WONG Kin Lu CHIOU Tzung Wern | 2003 | Antennas and Propagation IEEE Transactions2003，51，5： | 1 |
| 16 | Climate-induced variations in productivity and planktonic ecosystem structure from the Younger Dryas to Holocene in the Cariaco Basin, Venezuela显示文摘 | WERNE J P HOLLANDER D J LYONS T W | 2000 | Paleoceanography2000，15，： | 1 |
| 17 | Cutting edge wear of tungsten carbide tool in continuous and interrupted cutting of a polymer composite显示文摘 | Wang D H Wern C W Ramulu M | 1995 | Materials and Manufacturing Processes1995，10，3： | 1 |
| 18 | Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium dependent显示文摘 | Werns S W | 1986 | Circulation1986，74，1： | 1 |
| 19 | In vitro differentiation of transplantable neural precursors from human embryonic stem cells显示文摘 | Zhang SC Werning M | 2001 | Nat Biotechnol2001，19，： | 1 |
| 20 | Manage-ment of T1-T2 glottic carcinomas显示文摘 | Mendenhall WM Werning JW Hinerman RW | 2004 | Cancer2004，100，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员