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| 1 | Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients显示文摘Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. | Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 5 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | Long term effects of non invasive mechanical ventilation on pulmonary haemodynamics in patients w ith chronic respiratory failure显示文摘 | Schonhofer B Barchfeld T Wenzel M | 2001 | Thorax2001，56，： | 2 |
| 4 | Current understanding of sepsis显示文摘 | Wenzel R P Pinsky M R Ulevitch R J | 1996 | Clin Infect Dis1996，22，3： | 1 |
| 5 | Near-infrared spectroscopy: does it function in functional activation studies of the adult brain? 显示文摘 | Obrig H Wenzel R Kohl M | 2000 | International Journal of Psychophysiology2000，35，2： | 1 |
| 6 | Continuous production of ethylene-based diblock copolymers using coordinative chain transfer polymerization显示文摘 | Hustad P D Kuhlman R L Arriola D J Carnahan E M Wenzel T T | | 0，，： | 1 |
| 7 | Impact of the changing epidemidogy of fungal infections in the 1990s 显示文摘 | Pfaller M Wenzel R | 1992 | Eur J Clin Microbiol Infect Dis1992，11，4： | 1 |
| 8 | Accuracy of caries detection with four storage phosphor systems and E - speed radiographs 显示文摘 | Hintze H Wenzel A Frydenberg M | 2002 | Dentomaxillofac Radiol2002，31，3： | 1 |
| 9 | Survivin-ΔEx3 and survivin-2B:two novel splice variants of the apoptosis inhibitor survivin with different anti-apoptosis properties显示文摘 | MAHOTKA C WENZEL M SPRINGER E | 1999 | Cancer Res1999，59，24： | 1 |
| 10 | Cone beam CT and conventional tomography for the detection of morphological temporomandibular joint changes显示文摘 | Hintze H Wiese M Wenzel A | 2007 | Dentomaxillofac Radiol2007，36，4： | 1 |
| 11 | Impact of the changing epidemiology og fungal infection in the 1990s显示文摘 | Pfaller M Wenzel R | 1992 | Eur J Clin Microbiol Infect Dis1992，11，4： | 1 |
| 12 | Division and apoptosis of E2f-deficient retinal progenitors显示文摘 | CHEN D PACAL M WENZEL P | 2009 | Nature2009，462，7275： | 1 |
| 13 | PreSEIS:A neural network-based approach to earthquake early warning for finite faults显示文摘 | B(o)se M Wenzel F Erdik M | 2008 | Bull Seismol Soc Am2008，98，： | 1 |
| 14 | Pilot study on theefficacy of an ondansetron-versus palonosetron-eontaining antiemetie regimen prior to highly emetogenic chemotherapy显示文摘 | Wenzell C M Berger M J Blazer M A | 2013 | Support Care Cancer2013，21，10： | 1 |
| 15 | HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration显示文摘 | Grimm C Wenzel A Groszer M | 2002 | Nat Med2002，8，7： | 1 |
| 16 | Survivin delta x-3 and Survivin--2B two novel splice variants of the apoptosis inhibitors Survivin with different antiapoptic properties显示文摘 | Mahotka G Wenzel M Springer E | | 0，，24： | 1 |
| 17 | An experimental study of axial dispersion in a countercurrent magnetically stabilized bed显示文摘 | FLEMING M R WENZEL L A CHAO T | 1991 | Powder Technology1991，64，： | 1 |
| 18 | HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration显示文摘 | Grimm C Wenzel A Groszer M etal | 2002 | Nat Med2002，8，7： | 1 |
| 19 | Survivin-ΔEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties显示文摘 | Mahotka C Wenzel M Springer E | 1999 | Cancer Res1999，59，24： | 1 |
| 20 | Molecular mechanisms of light - induced photoreceptor apoptosis and neuroprotection for retinal degeneration 显示文摘 | Wenzel A Grimm C Samardzija M | 2005 | Prog Retin Eye Res2005，24，2： | 1 |
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