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| 1 | TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-αpathway显示文摘Background:Inflammation is a complex physiological and pathological process.Although many types of inflammation are well characterized,their physiological func-tions are largely unknown.tRNA aspartic acid methyltransferase 1(TRDMT1)has been implicated as a stress-related protein,but its intrinsic biological role is unclear.Methods:We constructed a Trdmt1 knockout rat and adopted the LPS-induced sepsis model.Survival curve,histopathological examination,expression of inflammatory fac-tors,and protein level of TLR4 pathway were analyzed.Results:Trdmt1 deletion had no obvious impact on development and growth.Trdmt1 de-letion slightly increased the mortality during aging.Our data showed that Trdmt1 strongly responded in LPS-treated rats,and Trdmt1 knockout rats were vulnerable to LPS treat-ment with declined survival rate.We also observed more aggravated tissue damage and more cumulative functional cell degeneration in LPS-treated knockout rats compared with control rats.Further studies showed upregulated TNF-αlevel in liver,spleen,lung,and serum tissues,which may be explained by enhanced p65 and p38 phosphorylation.Conclusions:Our data demonstrated that Trdmt1 plays a protective role in inflamma-tion by regulating the TLR4-NF-κB/MAPK-TNF-αpathway.This work provides useful information to understand the TRDMT1 function in inflammation. | Zhengguang Li Xiaolong Qi Xu Zhang Lei Yu Lijuan Gao Weining Kong Wei Chen Wei Dong Lijun Luo Dan Lu Lianfeng Zhang Yuanwu Ma | 2022 | Animal Models and Experimental Medicine2022，5，2： | 5 |
| 2 | Investigation on induction brazing of profiled cBN wheel for grinding of Ti-6Al-4V显示文摘Profiled monolayer cBN wheel was induction brazed for grinding of titanium dovetail slot in this study.Aimed at acquiring a uniform temperature distribution along the profiled surface and reducing the thermal deformation of the brazed wheel,a finite element model was established to investigate the temperature uniformity during induction brazing.A suitable induction coil and the related working parameters were designed and chosen based on the simulation results.Ag-Cu-Ti alloy and cBN grains were applied in the induction brazing experiment.The results showed geometric deformation of the brazed wheel was no more than 0.01 mm and chemical reaction layer were found on the brazed joint interface.Further validation tests were carried out by grinding of Ti-6 Al-4 V alloy.Compared to the electroplated wheel,the brazed wheel showed better performance such as low specific grinding energy and good ground quality in grinding of Ti-6 Al-4 V alloy.Abrasion wear was found to be the main failure mode for the induction brazed wheel,while adhesion and grains pull-out were the main failure mode for the electroplated wheel. | Qilin LI Kai DING Weining LEI Jiajia CHEN Qingshan HE Zhenzhen CHEN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 2 |
| 3 | Application of an antibody chip for screening differentially expressed proteins during peach ripening and identification of a metabolon in the SAM cycle to generate a peach ethylene biosynthesis model显示文摘Peach(Prunus persica)is a typical climacteric fruit that produces ethylene rapidly during ripening,and its fruit softens quickly.Stony hard peach cultivars,however,do not produce large amounts of ethylene,and the fruit remains firm until fully ripe,thus differing from melting flesh peach cultivars.To identify the key proteins involved in peach fruit ripening,an antibody-based proteomic analysis was conducted.A mega-monoclonal antibody(mAb)library was generated and arrayed on a chip(mAbArray)at a high density,covering~4950 different proteins of peach.Through the screening of peach fruit proteins with the mAbArray chip,differentially expressed proteins recognized by 1587 mAbs were identified,and 33 corresponding antigens were ultimately identified by immunoprecipitation and mass spectrometry.These proteins included not only important enzymes involved in ethylene biosynthesis,such as ACO1,SAHH,SAMS,and MetE,but also novel factors such as NUDT2.Furthermore,protein–protein interaction analysis identified a metabolon containing SAHH and MetE.By combining the antibody-based proteomic data with the transcriptomic and metabolic data,a mathematical model of ethylene biosynthesis in peach was constructed.Simulation results showed that MetE is an important regulator during peach ripening,partially through interaction with SAHH. | Wenfang Zeng Liang Niu Zhaohui Wang Xiaobei Wang Yan Wang Lei Pan Zhenhua Lu Guochao Cui Weining Weng Mingqiao Wang Xun Meng Zhiqiang Wang | 2020 | Horticulture Research2020，7，1： | 2 |
| 4 | Vapor phase growth of two-dimensional PdSe2 nanosheets for high-photoresponsivity near-infrared photodetectors显示文摘Palladium diselenide(PdSe2),a stable layered material with pentagonal structure,has attracted extensive interest due to its excellent electrical and optoelectronic performance.Here,we report a reliable process to synthesize PdSe2 via chemical vapor deposition(CVD)method.Through systematic regulation of temperature in the growth process,we can tune the thickness,size,nucleation density and morphology of PdSe2 nanosheets.Field-effect transistors based on PdSe2 nanosheets exhibit n-type behavior and present a high electron mobility of 105 cm^2·V^−1·s^−1.The electrical property of the devices after 6 months keeping in the air show little change,implying outstanding air-stability of PdSe2.In addition,PdSe2 near-infrared photodetector shows a photoresponsivity of 660 A·W^−1 under 914 nm laser.These performances are better than those of most CVD-grown 2D materials,making ultrathin PdSe2 a highly qualified candidate material for next-generation optoelectronic applications. | Weiting Xu Jiayang Jiang Huifang Ma Zhengwei Zhang Jia Li Bei Zhao Ruixia Wu Xiangdong Yang Hongmei Zhang Bailing Li Weining Shu Zucheng Zhang Bo Li Yuan Liu Lei Liao Xidong Duan | 2020 | Nano Research2020，13，8： | 1 |
| 5 | Geneticdiversity of mitochondrial eytochrome b gene in Chinese native buffalo显示文摘 | LEI C Z ZHANG C M WEINING S | 2011 | Anita Genet2011，42，4： | 1 |
| 6 | Synthesis ofnanocrystalline nickel in pulse deposition显示文摘 | LEI Weining ZHU Di QU Ningsong | 2002 | Transactions of theInstitute of Metal Finishing2002，80，6： | 1 |
| 7 | Electrodeposition of bright nickel coating under perturbation of hard particles显示文摘 | Zengwei Zhu Di Zhu Ningsong Qu Weining Lei | 2006 | Materials and Design2006，，6： | 1 |
| 8 | C-V char- acteristic of MFIS structure显示文摘 | Yan Lei Tang Ting'ao Huang Weining | 2000 | Chinese Journal of Semicon- ductors2000，21，12： | 1 |
| 9 | Genetic diversity of mitochondrial cytochrome b gene in Chinese native buffalo显示文摘 | Lei C Z Zhang C M Weining S | 2011 | Animal genetics2011，42，4： | 1 |
| 10 | Synthesis of nanocrystalline nickel in pulse deposition显示文摘 | Lei Weining Zhu Di Qu Ningsong | 2002 | Transactions of the Institute of Metal Finishing2002，80，6： | 1 |
| 11 | Direct observation of spreading precursor liquids in a corner显示文摘Precursor liquid is a nanoscale liquid creeping ahead of the macroscopic edge of spreading liquids,whose behaviors tightly correlate with the three-phase reaction efficiency and patterning accuracy.However,the important spatial-temporal characteristic of the precursor liquid still remains obscure because its real-time spreading process has not been directly observed.Here,we report that the spreading ionic liquid precursors in a silicon corner can be directly captured on video using in situ scanning electron microscopy.In situ spreading videos show that the precursor liquid spreads linearly over time(ΔL~ΔT)rather than obeying the classic Lucas-Washburn law(l~t^(1/2))and possesses a characteristic width of~250-310 nm.Theoretical analyses and molecular dynamics simulations demonstrate that the unique behaviors of precursor liquids originate from the competing effect of van der Waals force and surface energy.These findings provide avenues for directly observing liquid/solid interfacial phenomena on a microscopic level. | Weining Miao Shihao Tian Quanzi Yuan Ye Tian Lei Jiang | 2023 | National Science Review2023，10，7： | 0 |
| 12 | Deleterious effects of electron beam irradiation on development and reproduction of tomato/potato psyllids, Bactericera cockerelli显示文摘The potato/tomato psyllid Bactericera cockerelli causes serious damage to several solanaceous crops by direct feeding and vectoring Candidatus Liberibacter solanacearum,a bacterial pathogen.Electron beam(eBeam)irradiation is an environmentally friendly,chemical-free alternative method that is increasing in use for disinfestation of insect pests.We hypothesize that this irradiation technology will have detrimental effects on potato psyllid and thus impede its disease vectoring.To this end,we explored the effects of eBeam treatment ranging from 50 to 500 Gy on survival,development and reproduction of this pest.Impact on psyllids was apparently dose-dependent.When irradiated at 350 Gy,eggs could not hatch,1st instar nymphs failed to emerge,and although a small portion of irradiated 5th instar nymphs survived,the emerged adults were mostly deformed.Abnormality in eclosed adults suggests harmful effects of eBeam on metamorphosis.Reproduction was seriously impaired when female psyllids were exposed to eBeam at the 5th instar nymphal or young adult stage,presumably due to inability to form oocytes.In addition,reciprocal crosses between irradiated and untreated psyllids indicated that female psyllids were more radiosensitive than males to eBeam.Taken together,these findings indicate that eBeam negatively impacted potato psyllid development and reproduction,which would inevitably compromise its disease transmission capacity.A dose of 350 Gy can be considered as a reference dose for effective control of potato psyllids. | Jiaxin Lei Jia Meng Ivy WChen Weining Cheng Andrea L.Beam Md-Sajedul Islam Woodward D.Bailey Suresh Pillai Keyan Zhu-Salzman | 2020 | Insect Science2020，27，6： | 0 |
| 13 | Patterns and impacting factors of gene evolutionary rate between wild and cultivated emmer wheat(Triticum turgidum)显示文摘Tetraploid emmer wheat(Triticum turgidum L.,BBAA)is the founder progenitor of bread wheat,providing the valuable genetic resource and gene pool for wheat improvement.However,the evolutionary trajectory of tetraploid wheat,especially the evolutionary fate of different types of genes has not been well studied.In this study,the rate of non-synonymous substitution(dN)and synonymous substitution(dS)was calculated by comparing the orthologs between the wild emmer and cultivated durum wheat at the whole genome and subgenome levels to obtain the positively selected genes(PSGs)and negatively selected genes(NSGs).Then,mutation rate,gene length,exon number,GC content,codon bias,and expression level were comprehensively investigated and compared between the PSGs and NSGs.Within both wild emmer and cultivated durum wheat,PSGs between A and B subgenome displayed shorter gene and exon lengths as well as fewer exon numbers compared with NSGs,whereas from wild emmer to cultivated durum wheat,PSGs showed longer gene length and more exon numbers.Furthermore,PSGs displayed much higher expression levels and stronger codon usage bias,but lower genetic diversity compared with NSGs.Finally,two PSGs TdER1-6B,and TdLC7-2A,were found to play the crucial roles in regulating grain width and plant height of tetraploid wheat,respectively.This study systematically investigated the evolutionary,structural,and functional difference between PSGs and NSGs in tetraploid wheat,which will contribute to a better understanding of the selective mode and evolutionary trajectory during wheat domestication and evolution. | Peng-Zheng Lei Qi Ai Zhu-Pei Xiong Jia-Nan Lu Xiu-Lan Wei Weining Song Xiao-Qin Liu Xiao-Jun Nie | 2023 | Journal of Systematics and Evolution2023，61，2： | 0 |
| 14 | Etiological characteristics of influenza-like illness in Jiangsu province from 2012 to 2016显示文摘Influenza-like illness(ILI)is an acute respiratory infection caused by various pathogens.However,the epidemiologic characteristics of ILI pathogens in Jiangsu province are unclear.To better understand the ILI etiology,the characteristics of the pathogens from nasopharyngeal swab samples of patients with ILI collected from 2012 to 2016 in 6 hospitals in Jiangsu province were studied.The pathogens,including influenza virus,respiratory syncytial virus(RSV),rhinovirus(HRV),adenovirus(ADV),herpes simplex virus(HSV),human coronavirus(hCoV),Streptococcus pneumoniae and Haemophilus influenzae,were detected by real-time PCR.At least one pathogen was identified in 1334 of the patients(40.23%).Among viruses,HRV,influenza A virus(Flu A),ADV and RSV were the most frequently detected.ADV was the only pathogen that was distributed evenly in different years and regions(P>0.05).The etiological distribution varied in different age groups.Streptococcus pneumoniae was the most common pathogen in co-infections with a co-detection rate of 64.57%(319/494).The spectrum of etiologies could help to estimate disease burden and provide guidance for vaccination. | Ke Xu Xiang Huo Rongqiang Zu Shenjiao Wang Yuanfang Qin Qigang Dai Xian Qi Huiyan Yu Lilin Chen Lei Hong Yangting Xu Qianhua Yi Weixiang Wang Xuan Wang Wenjun Dai Jie Zha Weining Han Changjun Bao | 2019 | The Journal of Biomedical Research2019，33，6： | 0 |
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