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| 1 | Flavonoid profiling of a traditional Chinese medicine formula of Huangqin Tang using high performance liquid chromatography显示文摘The quality control processes for herbal medicines have been problematic. Flavonoids are the major active components of Huangqin Tang(HQT, a traditional Chinese medicine formula). In this study, we used a combinative method approach consisting of chromatographic fingerprinting(high performance liquid chromatography; HPLC), quantitative methods and a pharmacodynamic evaluation model to analyze the flavonoids of HQT obtained from different sources. Ten batches of HQT were analyzed by the HPLC fingerprinting method and 26 common peaks were detected, of which 23 peaks corresponded with the chemical profile of HQT. In addition, 11 major compounds were identified by LC–MS analysis(liquid chromatography–tandem mass spectrometer; LC–MS^n) and quantified by the HPLC quantitative method approach. The studied10 batches of HQT were found to be homogeneous in their composition with a similarity between 0.990 and1.000. The distribution of the 11 identified compounds was found to be very similar among the batches. Only slight pharmacodynamic differences were detected between the different batches, confirming the homogeneity of HQT. The results of this study prove that the combination of chromatographic fingerprinting and quantitative analysis can be readily used for comprehensive quality control of herbal medicines. | Tao Li Shuaixing Zhuang Yiwei Wang Yanli Wang Weihao Wang Huihui Zhang Li Chen Dunfang Wang Zhongming Zhou Weipeng Yang | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 19 |
| 2 | The effects of spring-neap tide on the phytoplankton community development in the Jiaozhou Bay, China显示文摘The development of the phytoplankton community was studied in the Jiaozhou Bay during the spring to neap tide in August2001, through three cruises and a 15 d continuous observation. This investigation indicates that diatom cell abundance increasedsharply following the end of a spring tide, from 9 cells/cm3 to a peak of 94 cells/cm3. The dominant species composition andabundance show a quick species sequence from spring to neap tide, and the dominant species at the start phase is Skeletomenacostatum, then changes to Chaetoceros curvisetus, finally it changes to Eucampia zodiacus. Silicate concentration increasesduring spring tide, as a result of nutrient replenishment from the watersediment interface, its initial average concentration inneap tide is 1.39 mmol/dm3 and reached the peak average concentration of 8.40 mmol/dm3 in spring tide. But the nitrogenconcentration dropped due to dilution by the low nitrogen seawater from the Huanghai Sea, its initial average concentration inneap tide is 67 mmol/dm3 and decreased to the average concentration of 54 mmol/dm3 in spring tide. The degree of siliconlimitation was decreased and phytoplankton, especially diatoms, responds immediately after nutrient replenishment in thewater column. Skeletonmea costatum, as one of the dominant species in the Jiaozhou Bay, shows a quicker response tonutrient availability than Eucampia zodiacus and Chaetoceros curvisetus. It is proposed that dominant species compositionand water column stability synchronously determine the development of phytoplankton summer blooms in the Jiaozhou bay. | LIUDongyan SUNJun LIUZhe CHENHongtao WEIHao ZHANGJing | 2004 | Acta Oceanologica Sinica2004，23，4： | 18 |
| 3 | Effects of molybdenum on the microstructure and mechanical properties of Ti(C,N)-based cermets with low Ni显示文摘微观结构和机械性质上的瞬间的效果经常我(C, N ) 有低 Ni 的基于的金属陶瓷系统地被学习了。瞬间(4-12wt .%) 的不同内容被增加进 Ti (C, N ) 基于的金属陶瓷。标本被常规粉末冶金学和真空 sintered 个别地在 1440, 1450,和 1460 ℃的温度制作。Themicrostructure 和破裂形态学被扫描电子显微镜调查,并且象横向的力量和坚硬那样的机械性质被测量。结果证明微观结构是一致的,当瞬间的内容是 8wt .% 时,边界阶段的厚度是中等的;在 1450 ℃的标本 sintered 的机械性质比 1440 和 1460 ℃的那些 sintered 擅长。当瞬间的内容是 8 wt.% , sintering 温度是 1450 ℃时,横向的力量和坚硬的综合性质是最好。 | WANG Saiyu XIONG Weihao YAN Mingshuang FAN Chou | 2006 | Rare Metals2006，25，1： | 17 |
| 4 | Pm21 from Haynaldia villosa Encodes a CC-NBS- LRR Protein Conferring Powdery Mildew Resistance in Wheat显示文摘 | Liping Xing Ping Hu Jiaqian Liu Kamil Witek Shuang Zhou Jiefei Xu Weihao Zhou Li Gao Zhenpu Huang Ruiqi Zhang Xiue Wang Peidu Chen Haiyan Wang Jonathan D.G. Jones Miroslava Karafiatova Jan Vrana Jan Baros Jaroslav Dolezel Yuanchun Tian Yufeng Wu Aizhong Cao | 2018 | Molecular Plant2018，11，6： | 16 |
| 5 | SIMO detection schemes for underwater optical wireless communication under turbulence显示文摘In underwater optical wireless communication(UOWC),a channel is characterized by abundant scattering/absorption effects and optical turbulence.Most previous studies on UOWC have been limited to scattering/absorption effects.However,experiments in the literature indicate that underwater optical turbulence(UOT)can cause severe degradation of UOWC performance.In this paper,we characterize an UOWC channel with both scattering/absorption and UOT taken into consideration,and a spatial diversity receiver scheme,say a singleinput–multiple-output(SIMO) scheme,based on a light-emitting-diode(LED) source and multiple detectors is proposed to mitigate deep fading.The Monte Carlo based statistical simulation method is introduced to evaluate the bit-error-rate performance of the system.It is shown that spatial diversity can effectively reduce channel fading and remarkably extend communication range. | Weihao Liu Zhengyuan Xu Liuqing Yang | 2015 | Photonics Research2015，3，3： | 16 |
| 6 | Cesium lead halide perovskite triangular nanorods as high-gain medium and effective cavities for multiphoton- pumped lasing显示文摘基于铯铅卤化物 perovskite, nanostructures 在综合 photonics 为非线性的光学和实际频率 upconversion 设备正在答应的高效的抽 multiphoton 的激光。然而,如此的激光的表演高度依赖于材料和洞的质量,它使他们的制造挑战性。此处,我们表明经由蒸汽方法制作的三角形的 nanorods 能作为抽 multiphoton 的激光的获得媒介和有效的洞服务的那铯铅卤化物 perovskite。我们观察了在刺激的放射激光的模式蓝移动在增加的刺激的 fluence 依赖的放射激光系列驱动充满效果的乐队引起的移动,它与 Burstein 苔藓的动力学适合很好。而且,在 CsPbBr 3 nanorods 放射激光的有效 multiphoton 能在一个宽刺激波长范围(700-1,400 nm ) 被认识到。放射激光的 multiphoton 的动力学被解决时间的光致发光光谱学调查,它显示电子洞血浆负责抽 multiphoton 的放射激光。这个工作能在放射激光的频率 upconversion 为铯铅卤化物 perovskite nanostructures 导致新机会和应用设备并且光互连系统。 | Xiaoxia Wang Hong Zhou Shuangping Yuan Weihao Zheng Ying Jiang Xiujuan Zhuang Hongjun Liu Qinglin Zhang Xiaoli Zhu Xiao Wang Anlian Pan | 2017 | Nano Research2017，10，10： | 10 |
| 7 | Effect of surface roughness on the aerodynamic performance of turbine blade cascade显示文摘The effect of surface roughness on the boundary development and loss behavior of turbine blades is investigated with different Reynolds numbers in this paper.The result shows that the velocity profile in boundary layer is plumper on rough surface than on smooth blade.The aerodynamic loss is lowered at low Reynolds number,but becomes significantly large at high Reynolds number.The total pressure loss coefficient of cascade can reach a top increase of 129%for rougher blades comparing with smooth blades at Re=300000. | Tao Bain Jingyuan Liu Weihao Zhang Zhengping Zou | 2014 | Propulsion and Power Research2014，3，2： | 9 |
| 8 | Effect of Powder Particle Size on the Properties and Microstructure of Ti(C,N)-Based Cermet显示文摘The influence of raw powder particle size on the properties and microstructures of Ti (C, N)-based cermets has been studied. The conclusions are as follows: The microsmictures of cermets were composed of two kinds of grains, the one with black cores surrounded by obvious rim structures, and the other whose cores were white with unconspicuous rim structures and adhesive phase. In the cermet made from fine powders, the amount of grains with white cores was much more than that in cermet made from coarse powders. In addition, their properties were also much better. | Yong Zheng, Weihao Xiong (Key State Laboratory of Die Technology, Huazhong University of Science and Technology, Wuhan 430074, China) | 2001 | Rare Metals2001，20，1： | 8 |
| 9 | The Electric Field Detector (EFD) onboard the ZH-1 satellite and firstobservational results显示文摘Previous studies have reported that, before or after occurrences of strong earthquakes, some low earth orbit satellites recorded ionospheric disturbances, including electromagnetic emissions and plasma fluctuations over the epicenter region or its conjugate point.Theoretically speaking, due to some electromagnetic coupling effect, electromagnetic emissions from the earthquake preparation zone could propagate from the lithosphere to the atmosphere, and could reach the ionosphere, even up to the inner magnetosphere. This paper introduces the electric field detector(EFD) onboard the ZhangHeng-1 satellite(ZH-1). The EFD is designed to measure electric field fluctuations within the broad frequency range of DC to 3.5 MHz, divided into 4 channels: ULF(DC–16 Hz), ELF(6 Hz–2.2 kHz), VLF(1.8 kHz–20 kHz) and HF(18 kHz–3.5 MHz). The sampling rates of the channels are 125 Hz, 5 kHz, 50 kHz and 10 MHz, respectively. The EFD includes4 spherical probes mounted on a over 4.5 m boom and an electronic box inside the satellite module. The resolution of the EFD is 1μV·m-1·Hz-1/2 at frequencies from DC to 16 Hz, and the sensitivity is 0.1 μV·m-1·Hz-1/2 at frequencies from 6 Hz to 2.2 kHz, 0.05 μV·m-1·Hz-1/2 in the band 1.8 kHz to 20 kHz, and 0.1μV·m-1·Hz-1/2 from 20 kHz to 3.5 MHz. The dynamic range from DC to 20 kHz is over 120 dB, and over96 dB from 20 kHz to 3.5 MHz. The EFD has two observation modes: survey mode and burst mode. The survey mode concentrates primarily on electric field power density values; the burst mode provides high sampling rate waveform data. The detailed configuration of the EFD onboard the ZH-1 is also introduced in this paper. During the six months' orbit test phase, the EFD recorded a number of natural electromagnetic emissions. Preliminary analysis of these data suggests that the EFD performs well onboard the ZH-1 and is meeting the requirements of the scientific objectives of ZH-1. | JianPing Huang JunGang Lei ShiXun Li ZhiMa Zeren Cheng Li XingHong Zhu WeiHao Yu | 2018 | Earth and Planetary Physics2018，2，6： | 8 |
| 10 | ZIF-8/LiFePO4 derived Fe-N-P Co-doped carbon nanotube encapsulated Fe2P nanoparticles for efficient oxygen reduction and Zn-air batteries显示文摘Iron-based oxygen reduction reaction(ORR)catalysts have been the focus of research,and iron sources play an important role for the preparation of efficient ORR catalysts.Here,we successfully use LiFePO4 as ideal sources of Fe and P to construct the heteroatom doped Fe-based carbon materials.The obtained Fe-N-P co-doped coral-like carbon nanotube arrays encapsulated Fe2P catalyst(C-ZIF/LFP)shows very high half-wave potential of 0.88 V in alkaline electrolytes toward ORR,superior to Pt/C(0.85 V),and also presents a high half-wave potential of 0.74 V in acidic electrolytes,comparable to Pt/C(0.8 V).When further applied into a home-made Zn-air battery as cathode,a peak power density of 140 mW·cm^-2 is reached,exceeds commercial Pt/C(110 mW·cm^-2).Besides,it also presents exceptional durability and methanol resistance compared with Pt/C.Noticeably,the preparation method of such a high-performance catalyst is simple and easy to optimize,suitable for the large-scale production.What’s more,it opens up a more sustainable development scenario to reduce the hazardous wastes such as LiFePO4 by directly using them for preparing high-performance ORR catalysts. | Huihui Jin Huang Zhou Pengxia Ji Chengtian Zhang Jiahuan Luo Weihao Zeng Chenxi Hu Daping He Shichun Mu | 2020 | Nano Research2020，13，3： | 8 |
| 11 | Well-ordered layered LiNi0.8Co0.1Mn0.1O2 submicron sphere with fast electrochemical kinetics for cathodic lithium storage显示文摘Nickel-rich layered oxides have drawn sustainable attentions for lithium ion batteries owing to their higher theoretical capacities and lower cost.However,nickel-rich layered oxides also have exposed several defects for commercial application,such as uncontrollable ordered layered structure,which leads to higher energy barrier for Li+diffusion.In addition,suffering from structural mutability,the bulk nickelrich cathode materials likely trigger overall volumetric variation and intergranular cracks,thus obstructing the lithium ion diffusion path and shortening the service life of the whole device.Herein,we report wellordered layered Li Ni0.8Co0.1Mn0.1O2 submicron spheroidal particles via an optimized co-precipitation and investigated as LIBs cathodes for high-performance lithium storage.The as-fabricated Li Ni0.8Co0.1Mn0.1O2 delivers high initial capacity of 228 mAh g–1,remarkable energy density of 866 Wh kg–1,rapid Li ion diffusion coefficient(10–9cm2s–1)and low voltage decay.The remarkable electrochemical performance should be ascribed to the well-ordered layered structure and uniform submicron spheroidal particles,which enhance the structural stability and ameliorate strain relaxation via reducing the parcel size and shortening Li-ion diffusion distance.This work anticipatorily provides an inspiration to better design particle morphology for structural stability and rate capability in electrochemistry energy storage devices. | Jianing Liang Yun Lu Jie Wang Xupo Liu Ke Chen Weihao Ji Ye Zhu Deli Wang | 2020 | Journal of Energy Chemistry2020，29，8： | 8 |
| 12 | Suspended particulate matter in Jiaozhou Bay:Properties and variations in response to hydrodynamics and pollution显示文摘Based on water samples collected and observations of currents, tidal levels as well as turbidities taken, respectively over a period of 15 and 7 d, in southwestern Jiaozhou Bay on August, 2001, it was found that: ( i ) the average content of non mineral component amounted to 87% of the suspended sediment matter (SPM) in Jiaozhou Bay,much higher than in estuaries and bays where turbidity is high and mineral particulates dominates; (ii) in contrast to high turbid bays, SPM was generally coarser than bed deposits and in upper water column than in lower water column in Jiaozhou Bay; (iii) in fair weathers, suspended sediment concentration (SPC) varied regularly within tidal cycles and neap-spring cycles, but the regularity was deformed in storms; and (iv) SPC was controlled by settling/resuspension near the bed and by advection at the surface at the study site with a depth of 20 m, suggesting weak vertical exchanges. It was concluded that SPM property of a low turbid bay is sensitive to pollution, and that the maintenance of low turbidity in the bay depends on less SPM supply, low waves and currents, and controlling on discharge of particulate pollutants. | YANGShilun MENGYi ZHANGJing XUEYuanzhong CHENHongtao WEIHao LIUZhe WURuiming WANGLingxiang YANGHua WANGLiang ZHANGWenxiang | 2004 | Chinese Science Bulletin2004，49，1： | 8 |
| 13 | Identification of autophagy signaling network that contributes to stroke in the ischemic rodent brain via gene expression显示文摘Autophagy plays a vital role in cerebral ischemia and may be a potential target for developing novel therapy for stroke. In this study, we constructed an autophagy-related pathway network by analyzing the genes related to autophagy and ischemic stroke, and the risk genes were screened. Two autophagy-related modules were significantly up-regulated and clustered to influence cerebral ischemia. Besides, three key modular genes(NFKB1, RELA, and STAT3) were revealed. With 5-fold cross validation, the ROC curves of NFKB1, RELA, and STAT3 were 0.8256, 0.8462, and 0.8923. They formed a complex module and competitively mediated the activation of autophagy in cerebral ischemia. In conclusion, a module containing NFKB1, RELA, and STAT3 mediates autophagy, serving as a potential biomarker for the diagnosis and therapy of ischemic stroke. | Kun Liang Lei Zhu Jinyun Tan Weihao Shi Qing He Bo Yu | 2015 | Neuroscience Bulletin2015，31，4： | 7 |
| 14 | Microstructure and shear strength of the brazed joint of Ti(C,N)-based cermet to steel显示文摘Firm joins were obtained between Ti(C,N)-based cermet and steel with Ag-Cu-Zn-Ni filler metal by vacuum brazing. The effects of technological parameters such as brazing temperature, holding time, and filler thickness on the shear strength of the joints were investigated. The microstructure of welded area and the reaction products of the filler metal were examined by scanning electron microscopy (SEM), metallographic microscope (OM), energy-dispersive X-ray analysis (EDS), and X-ray diffraction (XRD). The brazing temperature of 870°C, holding time of 15 min, and filler thickness of 0.4 mm are a set of optimum technological parameters, under which the maximum shear strength of the joints, 176.5 MPa, is achieved. The results of microstructure show that the wettability of the filler metal on Ti(C,N)-based cermet and steel is well. A mutual solution layer and a diffusion layer exist between the welding base materials and the filler metal. | YE Dameng, XIONG Weihao, Zhang Xiuhai, QU Jun, and YAO Zhenghua State Key Laboratory of Plastic Forming Simulation and Die & Mould Technology, Huazhong University of Science and Technology, Wuhan 430074, China | 2010 | Rare Metals2010，29，1： | 7 |
| 15 | Bisphosphonate-based nanocomposite hydrogels for biomedical applications显示文摘Nanocomposite hydrogels consist of polymeric network embedded with functional nanoparticles or nanostructures,which not only contribute to the enhanced mechanical properties but also exhibit the bioactivities for regulating cell behavior.Bisphosphonates(BPs)are capable of coordinating with various metal ions and modulating bone homeostasis.Thanks to the inherent dynamic properties of metal–ligand coordination bonds,BPbased nanocomposite hydrogels possess tunable mechanical properties,highly dynamic structures,and the capability to mediate controlled release of encapsulated therapeutic agents,thereby making them highly versatile for various biomedical applications.This review presents the comprehensive overview of recent developments in BP-based nanocomposite hydrogels with an emphasis on the properties of embedded nanoparticles(NPs)and interactions between hydrogel network and NPs.Furthermore,various challenges in the biomedical applications of these hydrogels are discussed to provide an outlook of potential clinical translation. | Weihao Yuan Zhuo Li Xian Xie Zhi-Yong Zhang Liming Bian | 2020 | Bioactive Materials2020，5，4： | 7 |
| 16 | State-of-the-Art Review of High-Throughput Statistical Spatial-Mapping Characterization Technology and Its Applications显示文摘Macroscopic materials are heterogeneous,multi-elementary,and complex.No material is homogeneous or isotropic at a certain small scale.Parts of the material that differ from one another can be termed'natural chips.'At different spots on the material,the composition,structure,and properties vary slightly,and the combination of these slight differences establishes the overall material performance.This article presents a state-of-the-art review of research and applications of high-throughput statistical spatialmapping characterization technology based on the intrinsic heterogeneity within materials.Highthroughput statistical spatial-mapping uses a series of rapid characterization techniques for analysis from the macroscopic to the microscopic scale.Datasets of composition,structure,and properties at each location are obtained rapidly for practical sample sizes.Accurate positional coordinate information and references to a point-to-point correspondence are used to set up a database that contains spatialmapping lattices.Based on material research and development design requirements,dataset spatialmapping within required target intervals is selected from the database.Statistical analysis can be used to select a suitable design that better meets the targeted requirements.After repeated verification,genetic units that reflect the material properties are determined.By optimizing process parameters,the assembly of these genetic unit(s)is verified at the mesoscale,and quantitative correlations are established between the microscale,mesoscale,macroscale,practical sample,across-the-scale span composition,structure,and properties.The high-throughput statistical spatial-mapping characterization technology has been applied to numerous material systems,such as steels,superalloys,galvanization,and ferrosilicon alloys.This approach has guided the composition and the process optimization of various materials. | Haizhou Wang Lei Zhao Yunhai Jia Dongling Li Lixi Yang Yuhua Lu Guang Feng Weihao Wan | 2020 | Engineering2020，6，6： | 7 |
| 17 | The transcription factor SlHY5 regulates the ripening of tomato fruit at both the transcriptional and translational levels显示文摘Light plays a critical role in plant growth and development,but the mechanisms through which light regulates fruit ripening and nutritional quality in horticultural crops remain largely unknown.Here,we found that ELONGATED HYPOCOTYL 5(HY5),a master regulator in the light signaling pathway,is required for normal fruit ripening in tomato(Solanum lycopersicum).Loss of function of tomato HY5(SlHY5)impairs pigment accumulation and ethylene biosynthesis.Transcriptome profiling identified 2948 differentially expressed genes,which included 1424 downregulated and 1524 upregulated genes,in the Slhy5 mutants.In addition,genes involved in carotenoid and anthocyanin biosynthesis and ethylene signaling were revealed as direct targets of SlHY5 by chromatin immunoprecipitation.Surprisingly,the expression of a large proportion of genes encoding ribosomal proteins was downregulated in the Slhy5 mutants,and this downregulation pattern was accompanied by a decrease in the abundance of ribosomal proteins.Further analysis demonstrated that SlHY5 affected the translation efficiency of numerous ripening-related genes.These data indicate that SlHY5 regulates fruit ripening both at the transcriptional level by targeting specific molecular pathways and at the translational level by affecting the protein translation machinery.Our findings unravel the regulatory mechanisms of SlHY5 in controlling fruit ripening and nutritional quality and uncover the multifaceted regulation of gene expression by transcription factors. | Weihao Wang Peiwen Wang Xiaojing Li Yuying Wang Shiping Tian Guozheng Qin | 2021 | Horticulture Research2021，8，1： | 6 |
| 18 | Tribological properties of TiAlN-coated cermets显示文摘Ti(C,N)-based cermets were coated with TiAlN using multi-arc ion plating technology. Sliding wear tests were performed on the coated cermets. The microstructure and morphologies of the coated cermets before and after friction and wear tests were characterized. The results show that the TiAlN coating surface was smooth and its root mean square roughness was 16.6 nm. The hardness (HK) of TiAlN coating lay-ers reached approximately 3200 and the critical load (Lc) under which the coating failure occurred was 59 N. The sliding wear test results show that the friction coefficients of the TiAlN-coated cermets were lower than that of the cermets without any coating. Under the same load, the adhesion phenomenon of the counterpart materials on the specimens was improved and the mean friction coefficient increased with in-creasing sliding velocity. When the sliding velocity was 0.26 m·s-1, the mass of the coated cermets reduced. At the same sliding velocity, the average friction coefficient of the TiAlN-coated cermets was lower under a higher load. The wear mechanisms of the TiAlN-coated cermets were mainly adhesive and abrasive wear. | ZHENG Liyun ZHAO Lixin XIONG Weihao | 2009 | Rare Metals2009，28，1： | 4 |
| 19 | Microstructure and cutting performance of Ti(C, N)-based cermets heat-treated in nitrogen显示文摘Ti(C, N)-based cermets were treated using hot isostatic pressing (HIP) at 1423 K in nitrogen. The microstructures compared with the as-sintered cermets were investigated using X-ray diffraction, scanning electron microscopy, transmis- sion electron microscopy, energy-dispersive X-ray analysis, and electron microprobe analysis. It was found that high nitro- gen activity in the surface zone resulted in the formation of gradient structure. Approximately 20-μm-deep, nitrogen-rich and titanium-rich hard surface zone was introduced by the heat treatment. The nitrogen activity was the driving force that caused the transportation of the atoms through the binder, titanium towards the surface, and tungsten and molybdenum in- wards. In the surface zone, the particle size became fine, the inner rim disappeared, and the volume fraction of the outer rim and the binder phase considerably reduced. Small grains of TiN, WC, Mo2C, and nitrogen-rich carbonitride phases formed in the surface zone during the heat treatment, improving the tribological property of the heat-treated cermet. | LIU Wenjun XIONG Weihao ZHENG Yong SHI Zengmin YE Jiajian | 2007 | Rare Metals2007，26，4： | 4 |
| 20 | Asymmetric distribution of cytokinins determines root hydrotropism in Arabidopsis thaliana显示文摘The phenomenon of plant root tips sensing moisture gradient in soil and growing towards higher water potential is designated as root hydrotropism,which is critical for plants to survive when water is a limited factor.Molecular mechanisms regulating such a fundamental process,however,are largely unknown.Here we report our identification that cytokinins are key signaling molecules directing root growth orientation in a hydrostimulation(moisture gradient)condition.Lower water potential side of the root tip shows more cytokinin response relative to the higher water potential side.Consequently,two cytokinin downstream type-A response regulators,ARR16 and ARR17,were found to be up-regulated at the lower water potential side,causing increased cell division in the meristem zone,which allows the root to bend towards higher water potential side.Genetic analyses indicated that various cytokinin biosynthesis and signaling mutants,including the arr16 arr17 double mutant,are significantly less responsive to hydrostimulation.Consistently,treatments with chemical inhibitors interfering with either cytokinin biosynthesis or cell division completely abolished root hydrotropic response.Asymmetrically induced expression of ARR16 or ARR17 effectively led to root bending in both wild-type and miz1,a previously known hydrotropism-defective mutant.These data demonstrate that asymmetric cytokinin distribution is a primary determinant governing root hydrotropism. | Jinke Chang Xiaopeng Li Weihao Fu Jiawen Wang Yueyuan Yong Hongyong Shi Zhaojun Ding Hong Kui Xiaoping Gou Kai He Jia Li | 2019 | Cell Research2019，29，12： | 4 |
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