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| 1 | Free-breathing radial volumetric interpolated breathhold examination vs breath-hold cartesian volumetric interpolated breath-hold examination magnetic resonance imaging of the liver at 1.5T显示文摘AIM: To compare breath-hold cartesian volumetric interpolated breath-hold examination(cVIBE) and freebreathing radial VIBE(rVIBE) and determine whether rVIBE could replace cVIBE in routine liver magnetic resonance imaging(MRI).METHODS: In this prospective study, 15 consecutive patients scheduled for routine MRI of the abdomen underwent pre- and post-contrast breath-hold cVIBE imaging(19 s acquisition time) and free-breathing rVIBE imaging(111 s acquisition time) on a 1.5T Siemens scanner. Three radiologists with 2, 4, and 8 years post-fellowship experience in abdominal imaging evaluated all images. The radiologists were blinded to the sequence types, which were presented in a random order for each patient. For each sequence, the radiologists scored the cVIBE and rVIBE images for liver edge sharpness, hepatic vessel clarity, presence of artifacts, lesion conspicuity, fat saturation, and overall image quality using a five-point scale. RESULTS: Compared to rVIBE, cVIBE yielded significantly(P < 0.001) higher scores for liver edge sharpness(mean score, 3.87 vs 3.37), hepatic-vessel clarity(3.71 vs 3.18), artifacts(3.74 vs 3.06), lesion conspicuity(3.81 vs 3.2), and overall image quality(3.91 vs 3.24). cVIBE and rVIBE did not significantly differ in quality of fat saturation(4.12 vs 4.03, P = 0.17). The inter-observer variability with respect to differences between rVIBE and cVIBE scores was close to zero compared to random error and inter-patient variation. Quality of rVIBE images was rated as acceptable for all parameters. CONCLUSION: rVIBE cannot replace cVIBE in routine liver MRI. At 1.5T, free-breathing rVIBE yields acceptable, although slightly inferior image quality compared to breath-hold cVIBE. | Sireesha Yedururi HyunSeon C Kang Wei Wei Nicolaus A Wagner-Bartak Leonardo P Marcal R Jason Stafford Brandy J Willis Janio Szklaruk | 2016 | World Journal of Radiology2016，8，7： | 9 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity显示文摘 | Ma Z Wei X Fontanilla C Noelker C Dodel R Hampel H Du Y | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 4 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 5 | 查看详情显示文摘 | Wei Y Connors E J Jia X R Wang C | | 0，，： | 1 |
| 6 | Akt SUMOylation regulates cell proliferation and tumorigenesis显示文摘 | Li R Wei J Jiang C | 2013 | Cancer Res2013，73，18： | 1 |
| 7 | Fast speciation of mercury in seawater by short-column high-performance liquid chromatography hyphenated to inductively coupled plasma spectrometry after on-line cation exchange column preconcentration 显示文摘 | Jia X Y Gong D R Han Y Wei C Duan T C Chen H T | 2012 | Talanta2012，88，： | 1 |
| 8 | Pressure transient and rate decline analysis for hydraulic fractured vertical wells with finite conductivity in shale gas reservoirs显示文摘 | Guo C Xu J Wei M Jiang R | 2014 | Journal of Petroleum Exploration and Production Technology2014，，： | 1 |
| 9 | Formation of ultranano- crystalline diamond films with nitrogen addition 显示文摘 | LIN C R LIAO W H WEI D H | 2011 | Diamond and Related Materials2011，20，3： | 1 |
| 10 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 11 | An order-disorder transition in Sr2IrD5: Evidence for square pyramidal IrD5 units from powder neutron diffraction data 显示文摘 | ZHUANG J HASTINGS J M CORLISS L M BAU R WEI C Y MOYER R O J | 1981 | J Solid State Chem1981，40，： | 1 |
| 12 | PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis 显示文摘 | Tsutsumi R Xie C Wei X | 2009 | J Bone Miner Res2009，10，： | 1 |
| 13 | Kinematical analyses and transmission efficiency of a preloaded ball screwoperating at high rotational speeds显示文摘 | Wei C C Lai R S | 2011 | Mechanism and Machine Theory2011，46，7： | 1 |
| 14 | Structure and properties of PbO2-CeO2 anodes on stainless steel显示文摘 | Song Y H Wei G Xiong R C | | 0，，24： | 1 |
| 15 | Phosphorus removal by acid mine drainage sludge from secondary effluents of municipal wastewater treatment plants显示文摘 | Wei X Viadero R C Bhojappa S | 2008 | Water Research2008，42，13： | 1 |
| 16 | Actuat显示文摘 | Wei B Y Hsu M C Su P G Lin H M Wu R J Lai H J Sensor | 2004 | B2004，101，： | 1 |
| 17 | Antibacterial ActiviW of Some Essential Oil Components against Five Foodborne Pathogens显示文摘 | Kim J Marshall M R Wei C | 1995 | Journal of agricultural and food chemistry1995，43，11： | 1 |
| 18 | Preparation and Characteriza- tion of EP/SiOz Composite Materials Containing PEG Flexible Chain显示文摘 | Lu S R Jiang Y M Wei C | 2009 | Journal of Materials Science2009，44，5： | 1 |
| 19 | Hepatocytes proteomic alteration and seroproteome analysis of HBV-transgenic mice显示文摘 | Ding C Wei H Sun R | 2009 | Proteomics2009，9，1： | 1 |
| 20 | Diamondoid hydrocarbons as a molecular proxy for thermal maturity and oil cracking: Geochemical models from hydrous pyrolysis显示文摘 | Wei Z B Moldowan J M Zhang S C Hill R Jarvie D M Wang H T Song F Q Fago F | 2007 | Org Geochem2007，38，2： | 1 |
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