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| 1 | Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis显示文摘BACKGROUND Acute severe ulcerative colitis unresponsive to systemic steroid treatment is a lifethreatening medical condition requiring hospitalization and often colectomy.Despite the increasing choice of medical therapy options for ulcerative colitis, the condition remains a great challenge in the field of inflammatory bowel diseases(IBD). The performance of the calcineurin inhibitor tacrolimus in this clinical setting is insufficiently elucidated.AIM To evaluate the short and long-term outcomes of tacrolimus therapy in adult inpatients with steroid-refractory acute severe ulcerative colitis.METHODS We conducted a retrospective monocentric study enrolling 22 patients at a tertiary care center for the treatment of IBD. All patients who were admitted to one of the wards of the Department of Gastroenterology and Hepatology of the Heidelberg University Hospital with acute severe ulcerative colitis between 2007 and 2018, and who received oral or intravenous tacrolimus for steroid-refractory disease were included. Baseline characteristics and data on the disease courses were retrieved from entirely computerized patient charts. The primary study endpoint was clinical response to tacrolimus therapy, resulting in discharge from the hospital. Secondary study endpoints were colectomy rate and time to colectomy, achievement of clinical remission under tacrolimus therapy, and the occurrence of side effects.RESULTSIn the majority of the 22 included patients(68.2%), tacrolimus therapy was initiated intravenously and subsequently converted to oral administration. The treatment duration was 128 ± 28.5 d(mean ± SEM), and the patients were followed up for 705 ± 110 d after treatment initiation. Among all patients, 86.4%were discharged from the hospital under continued oral tacrolimus therapy. In36.4% of the patients, the administration of tacrolimus resulted in clinical remission at some point during the treatment. Thirty-two percent of the patients underwent colectomy between 5 and 194 d after the initiation of tacrolimus treatment(mean: 97.4 ± 20.8 d). Colectomy-free survival rates at 1, 3, 6 and 12 mo after the initiation of tacrolimus therapy were 90.9%, 86.4%, 77.3% and 68.2%,respectively. The safety profile of tacrolimus was overall favorable. Only two patients discontinued the treatment due to side effects.CONCLUSION The short-term outcome of tacrolimus in steroid-refractory acute severe ulcerative colitis was beneficial, and side effects were rare. In all, tacrolimus therapy appears to be a viable option for short-term treatment of steroidrefractory acute severe ulcerative colitis besides ciclosporin and anti-tumor necrosis factor α treatment. | Peter Hoffmann Cyrill Wehling Johannes Krisam Jan Pfeiffenberger Nina Belling Annika Gauss Department of | 2019 | World Journal of Gastroenterology2019，25，13： | 2 |
| 2 | Modulation of myostatin expression during modified muscle use显示文摘 | Wehling M Cai B Tidhall J G | 2000 | Faseb J2000，14，： | 1 |
| 3 | Multifunction millimeter-wave systemsfor armored vehicle application显示文摘 | John H Wehling | 2005 | IEEE Transactions onMicrowave Theory and Techniques2005，53，3： | 1 |
| 4 | Near- infrared spectro- scopic determination of degradation in vegetable oils used to fry various foods 显示文摘 | Ng C L Wehling R L Cuppet S L | 2011 | Journal of Agricultural and Food Chem- istry2011，59，12： | 1 |
| 5 | A novel formulation technique for metered dose inhaler (MDI) suspensions 显示文摘 | Steekel H Wehle S | 2004 | Int J Pharm2004，284，： | 1 |
| 6 | Multifunction millimeter-wave systems for armored vehicle application 显示文摘 | WEHLING J H | 2005 | IEEE Transactions on Mi- crowave Theory and Techniques2005，53，3： | 1 |
| 7 | Translational medicine:science or wishful thinking显示文摘 | Wehling M | | 0，，： | 1 |
| 8 | Extraction of cholesterol and other lipids from dried egg yolk using supercritical carbondioxide显示文摘 | Froning G Wehling R Cuppett S | 1990 | J Food Sci1990，55，1： | 1 |
| 9 | Transfer of genes to chondrocytic cells of Ihe lumbar spine:proposal for a treatment strategy of spinal disorders by local gene therapy显示文摘 | Wehling P Schulitz KP Tobbins PD | 1997 | Spine1997，22，： | 1 |
| 10 | Multifunction Millimeter-Wave systems for armored vehicle application显示文摘 | John H Wehling | 2005 | IEEE Transaction on Microwave Theory and Techniques2005，3，： | 1 |
| 11 | Translational medicine: science or wishfu thinking显示文摘 | Wehling M | 2008 | J Transl Med2008，6，： | 1 |
| 12 | Method for determining frying oil degradation by near-infrared spectroscopy显示文摘 | Choo Lum Ng Randy L Wehling Susan L Cuppet | 2007 | Journal of Agricultural and Food Chemistry2007，，55： | 1 |
| 13 | Modulation of myostatin expression during modified muscle use显示文摘 | Wehling M Cai B Tidball J G | | 0，，： | 1 |
| 14 | Moni- toring PV in corn and soybean oils by NIR spectrosco py显示文摘 | YILDIZ G WEHLING R L CUPPETT S L | 2002 | Journal of the American Oil Chemists Society2002，79，11： | 1 |
| 15 | The headquarters-subsidiaries trench: tracing perception gaps within the multinational corporation 显示文摘 | Tina Chini Bjom Ambos Katrin Wehle | 2005 | European Management Journal2005，23，2： | 1 |
| 16 | Identification of Microsatellite Polymorphisms in an Expressed Portion of the Rye Genome显示文摘 | Hackauf B Wehling P | 2002 | Plant Breed2002，，121： | 1 |
| 17 | Investigation of pigments in medieval manuscripts by micro raman spectroscopy and Total Reflection X- Ray fluorescence spectrometry显示文摘 | Bernhard Wehling Peter Vandenabeele Luc Moens | 1999 | Mikrochim Acta1999，130，： | 1 |
| 18 | Recognition of a human sperm surface protein involved in the progesterone-initiated acrosome reaction by antisera against an endomembrane progesterone binding protein from porcine liver 显示文摘 | Buddhikot M Falkenstein E Wehling M | 1999 | Mol Cell Endocrinol1999，158，12： | 1 |
| 19 | A new hypothesis of modular glucocorticoid actions:steroid treatment of rheumatic diseases revisited显示文摘 | Buttgereit F Wehling M Burmester GR | 1998 | Arthritis Rheum1998，41，5： | 1 |
| 20 | Sequencing of HLA class Ⅱ genes based on the conserved diversity of the non-coding regions:sequencing based typing of HLA-DRB genes显示文摘 | Kotsch K Wehling J Blasczyk R | 1999 | Tissue Antigens1999，53，5： | 1 |
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