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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Removal of selected metal ions from aqueous solution using modified corncobs显示文摘 | Trivette Vaughan Chung W Seo Wayne E Marshall | 2001 | Bioresource Technology2001，，2： | 2 |
| 3 | Grading system modification and management of blunt aortic injury显示文摘 | Kaavya N Reddy Tim Matatov Linda D Doucet Maureen Heldmann Cynthia X Zhao Wayne W Zhang | 2013 | Chinese Medical Journal2013，，3： | 2 |
| 4 | Microsatellites and their application to population genetic studies显示文摘 | BRUFORD M W WAYNE R K | 1993 | Current Opinion in Genetics and Development1993，3，： | 1 |
| 5 | Properties, problems and adhensive technology of crop straw panel显示文摘 | Wayne W Wang S G | 2001 | Wood-basedPanels2001，1217，： | 1 |
| 6 | Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association显示文摘 | Li W H Wayne A | 2004 | PNAS2004，101，8： | 1 |
| 7 | Tectonic contraction across Los Angeles after removal of groundwater pumping effects 显示文摘 | Gerald W Bawden Wayne Thatcher Ross S Stein | 2001 | Nature2001，412，6849： | 1 |
| 8 | A corporate govern- ance explanation of the A-B share discount in China 显示文摘 | Tong Wilson H S Yu Wayne W | 2012 | Journal of International Money and Finance2012，31，2： | 1 |
| 9 | Verruca plantaris显示文摘 | WAYNE W | 1955 | Calif Med1955，82，2： | 1 |
| 10 | A practical scientific app roach to riparian vegetation rehabilitation in Australia显示文摘 | Ashley A W Wayne D E | 2003 | Journal of Environmental Management2003，68，4： | 1 |
| 11 | Ch OpenCV for interactive open architecture computer vision显示文摘 | Qingcang Yu Harry H Cheng Wayne W Cheng | 2004 | Advances in Engineering Software2004，35，9： | 1 |
| 12 | Treatment of Multiple Sleep Problems in Children with Developmental Disabilities:Faded Bedtime with Response Cost Versus Bedtime Scheduling 显示文摘 | Cathleen C P Wayne W F | 1997 | Developmental Medicine and Child Neurology1997，，39： | 1 |
| 13 | Treatment of generalized anxiety disorder with escitalopram:Pcoled results from double-blind,placebo-controlled trials显示文摘 | WAYNE K GOODMAN A B QIN W | 2005 | Journal of Affective Disorders2005，87，： | 1 |
| 14 | Dynamic adsorption of radon by activated carbon 显示文摘 | WAYNE C G UNDERHILL D W | 2005 | Health Physics2005，88，4： | 1 |
| 15 | A numerical model for the point contact of dissimilar materials considering tangential tractions 显示文摘 | WAYNE C W JANE W Q | 2008 | Mechanics of Materials2008，，： | 1 |
| 16 | Experimental study on micro-macro manipulator vibration control显示文摘 | DAVID W C DAVID P M WAYNE J B | 1996 | ICRA1996，，： | 1 |
| 17 | New national guidelines on hypertension:A summary for dentistry显示文摘 | Joseph L Michael LP | 2004 | J Am Dent Assoc2004，135，5： | 1 |
| 18 | A numerical model for the point contact of dissimilar materials considering tangential tractions 显示文摘 | Wayne C W Jane W Q | 2008 | Mechanics of Materials2008，40，： | 1 |
| 19 | Accumulation and crop uptake of soil mineral nitrogen as influenced by tillage,cover crops,and nitrogen fertilization显示文摘 | Upendra M S Bharat P S Wayne F W | 2007 | Agronomy Journal2007，99，： | 1 |
| 20 | Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood:preclinical studies and phase I clinical trial显示文摘 | Wayne A S Kreitman R J Findley H W | 2010 | Clin Cancer Res2010，16，6： | 1 |
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