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| 1 | Who benefits from percutaneous closure of patent foramen ovale vs medical therapy for stroke prevention? In-depth and updated metaanalysis of randomized trials显示文摘BACKGROUND A few randomized clinical trials(RCT) and their meta-analyses have found patent foramen ovale closure(PFOC) to be beneficial in prevention of stroke compared to medical therapy. Whether the benefit is extended across all groups of patients remains unclear.AIM To evaluate the efficacy and safety of PFOC vs medical therapy in different groups of patients presenting with stroke, we performed this meta-analysis of RCTs.METHODS Electronic search of PubMed, EMBASE, Cochrane Central, CINAHL and ProQuest Central and manual search were performed from inception through September 2018 for RCTs. Ischemic stroke(IS), transient ischemic attack(TIA), a composite of IS, TIA and systemic embolism(SE), mortality, major bleeding,atrial fibrillation(AF) and procedural complications were the major outcomes.Random-effects model was used to perform analyses.RESULTS Meta-analysis of 6 RCTs including 3560 patients showed that the PFOC,compared to medical therapy reduced the risk of IS [odds ratio: 0.34; 95%confidence interval: 0.15-0.78; P = 0.01] and the composite of IS, TIA and SE [0.55(0.32-0.93); P = 0.02] and increased the AF risk [4.79(2.35-9.77); P < 0.0001]. No statistical difference was observed in the risk of TIA [0.86(0.54-1.38); P = 0.54],mortality [0.74(0.28-1.93); P = 0.53] and major bleeding [0.81(0.42-1.56); P = 0.53]between two strategies. Subgroup analyses showed that compared to medical therapy, PFOC reduced the risk of stroke in persons who were males, ≤ 45 years of age and had large shunt or atrial septal aneurysm.CONCLUSION In certain groups of patients presenting with stroke, PFOC is beneficial in preventing future stroke compared to medical therapy. | Khagendra Dahal Adil Yousuf Hussam Watti Brannen Liang Sharan Sharma Jharendra Rijal Pavan Katikaneni Kalgi Modi Neeraj TANDon Michael Azrin Juyong Lee | 2019 | World Journal of Cardiology2019，11，4： | 4 |
| 2 | Existence theorem for travelling waves on lattices 显示文摘 | Friesecke G Wattis J | 1994 | Communications in Mathematical Physics1994，161，2： | 1 |
| 3 | Procalcitonin:a marker ofbacteraemia in SIRS显示文摘 | Bell K Wattie M Byth K | 2003 | Anaesth Intensive Care2003，31，： | 1 |
| 4 | The effects of intranasal budesonide on allergen-induced production of interleukin-5 and eotaxin, airways, blood, and bone marrow eosinophilia, and eosinophil progenitor expansion in sensitized mice 显示文摘 | Shen H O'Byrne PM Ellis R Wattie J Tang C Inman MD | 2002 | Respir Crit Care Med2002，166，2： | 1 |
| 5 | Procalcitonin:a marker of hacteraemia in SIRS 显示文摘 | Bell K Wattie M Byth K | 2003 | Anaesth Intensive Care2003，31，6： | 1 |
| 6 | Procalcitonin: a marker of bacteraemia in SIRS 显示文摘 | Bell K Wattie M Byth K | 2003 | Anaesth Intensive Care2003，31，6： | 1 |
| 7 | Procalcitonin:A marker of bacteraemia in SIRS显示文摘 | Bell K Wattie M Byth K | 2003 | Anaesth Intensive Care2003，31，6： | 1 |
| 8 | Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis显示文摘 | Botha S S WattI Slagboom E et a1 | 2008 | Ann Rheum Dis2008，67，8： | 1 |
| 9 | Effects of a β-blocker on bone turnover in normal postmenopausal women:a randomized controlled trial显示文摘 | REID I LUCAS J WATTIE D | 2005 | Journal of Clinical Endocrinology & Metabolism2005，90，9： | 1 |
| 10 | Allergen-induced increase in airway responsiveness。airway eosinophilia and bone marrow eosinophil progenilors in mice显示文摘 | Inman MD Ellis R Wattie J et a1 | 1999 | Am J Respir Cell Mol Biol1999，21，： | 1 |
| 11 | Procaleitonin : a Balker of bacteremia in SIRS显示文摘 | Bell K Wattie M Syth K | 2003 | Anacsth Intensive Care2003，31，6： | 1 |
| 12 | Modelling the regulation of telom- ere length:the effects of telomerase and G-quadruplex stabilising drugs 显示文摘 | Hirt BV Wattis JA Preston SP | 2014 | Journal of Mathematical Biology2014，68，6： | 1 |
| 13 | Dysfunction and remodeling of the mouse airway persis after resolution of acute allergeninduced airway inflammation显示文摘 | Leigh R Ellis R Wattie J | 2002 | Am J Respir Cell Mol Boil2002，27，5： | 1 |
| 14 | Type 2 cytokines in the pathogenesis of sustained airway dysfunetion and airway remod - eling in mice 显示文摘 | Leigh R Ellis R Wattie JN | 2004 | Am J Respir Crit Care Med2004，169，7： | 1 |
| 15 | Procalcitonin : a marker of bacteravmia in SIRS显示文摘 | Bell K Wattie M Byth K | 2003 | Anaesth Intensive Care2003，31，6： | 1 |
| 16 | Procalcitonin:a marker of bacteraemia in SIRS显示文摘 | BELL K WATTIE M BYTH K | 2003 | Anaesth Intensive Care2003，31，6： | 1 |
| 17 | Allergen- induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhi- nitis显示文摘 | SAITO H HOWIE K WATTIE J | 2001 | Immunology2001，104，： | 1 |
| 18 | Amelioration of ovalbumin-induced allergic airway disease following Der pl peptide immunotherapy is not associated with induction of IL-35显示文摘 | Moldaver DM Bharhani MS Wattie JN | 2014 | Mucosal Immunol2014，7，2： | 1 |
| 19 | Type 2 cytokin-es in the pathogenesis of sustainee airway dysfunction and airway remodeling in mice显示文摘 | LEIGH R ELLIS R WATTIE J N | 2004 | Am J Respir Crit Care Med2004，169，： | 1 |
| 20 | Students' approaches to assessment in accounting education: the unique student perspective 显示文摘 | Watty K Jackson M Yu X | 2010 | Accounting Education: An International Journal2010，19，3： | 1 |
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