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19篇 您的检索式：作者名="Watson PL"

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		题名	作者	年代	出处	被引量
	1	miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium.	Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey	2011	World Journal of Gastroenterology2011，17，8：	13
	2	Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-as-sociated lactonase and protects low density lipoprotein against oxidation显示文摘	Stetson PL Watson CE	2000	J Biol Chem2000，275，33：	1
	3	Molecular phylogeny of subtribe Artemisiinae (Asteraceae), including Artemisia and its allied and segregate genera 显示文摘	Watson LE Bates PL Evans TM	2002	BMC Evol Biol2002，2，：	1
	4	Presence of electroencephalogram burst suppression in sedated,critically ill patients is associated with increased mortality显示文摘	Watson PL Shintani AK Tyson R		0，，12：	1
	5	Measuring sleep in critically ill patients: beware the pitfalls显示文摘	Watson PL	2007	Crit Care2007，11，4：	1
	6	Effects of steroids on cerebral electrical activity显示文摘	Watson CW Goldman PL	1966	Arch Neurol1966，15，：	1
	7	Bench-to-bedside review:delirium in ICU patients-importance of sleep deprivation显示文摘	Weinhouse GL Schwab RJ Watson PL		0，，06：	1
	8	Effects of variations in hippocampal slice preparation protocol on the electrophysiological stability, epileptogenicity and graded hypoxia responses of CA1 neurons显示文摘	Watson PL Weiner JL Carlen PL	1997	Brain Res1997，775，12：	1
	9	Bench-to-bedside review: delirium in ICU patients-importance of sleep deprivation 显示文摘	Weinhouse GL Schwab R J Watson PL	2009	Crlt Care2009，13，6：	1
	10	Cisplatin inhibits paclitaxel-induced apoptosis in cisplatin-resistant ovarian cancer cell lines显示文摘	Judson PL Watson JM Gehrig PA	1999	Cancer Res1999，59，5：	1
	11	Peroxisome proliferator-activated receptor (PPAR)-alpha activiation lowers muscle lipids and improves insulin sensitivily in high fat rat: comparision with PPAR-gamma activation显示文摘	Ye JM Doyle PL Iglesias MA Watson DG Cooney GJ Kraegen	2001	Diabetes2001，50，：	1
	12	Gastrointestinal tolerability of the selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib compared with nonselective COX-1 and COX-2 inhibitors in osteoarthrits 显示文摘	Watson DJ Harper SE Zhao PL	2000	Arch Intern Med2000，160，19：	1
	13	Rabbit serum paraoxonase 3(PON3)is a high-density lipoprotein-associated lactonase and protects lipoprotein against oxidation显示文摘	Draganov D Stetson PL Watson C	2000	J Biol Chem2000，275，33：	1
	14	Magnesium sulfate: rationale for its usein pre-eclampsia显示文摘	Watson KV Moldow CF Ogburn PL Jacob HS	1986	Proc Natl Acad Sci USA1986，83，：	1
	15	Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associ- ated lactonase and protects low density lipoprotein against oxidation显示文摘	Draganov DI Stetson PL Watson CE	2000	J Biol Chem2000，275，33：	1
	16	Bench-to-bedside review:delirium in ICU patients-importance of sleep deprivation显示文摘	Weinhouse GL Schwab RJ Watson PL	2009	Crit Care2009，13，6：	1
	17	Bench-to-bedside review:delirium in ICU patients-importance of sleep deprivation 显示文摘	Weinhouse GLtSchwab RJ Watson PL	2009	Crit Care2009，13，6：	1
	18	Bench-to-bedside review:delirium in ICU patients-importance of sleep deprivation显示文摘	Weinhouse GL Schwab RJ Watson PL	2009	Crit Care2009，13，6：	1
	19	Cisplatin inhibits paclitaxel-induced apoptosis in cisplatin-resistant ovarian cancer cell lines: possible explanation for failure of combination therapy显示文摘	Judson PL Watson JM Gehrig PA	1999	Cancer Res1999，59，10：	1

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