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| 1 | 成人、儿童及孕妇特发性血小板减少性紫癜诊治指南显示文摘特发性血小板减少性紫癜(ITP)是一种自体免疫性疾病,以持续性血小板减少为特征(血小板<150×109/L).其发病机理是自身抗体与血小板抗原结合导致它们在未成熟时即被网状内皮系统,特别是在脾脏中被破坏引起血小板减少. | Provan D Newland A Norfolk D Bolton-Maggs P Lilleyman J Greer I May A Murphy M Ouwehand W Watson S 李振宇 徐开林 | 2004 | 国外医学(输血及血液学分册)2004，27，4： | 25 |
| 2 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 3 | Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation显示文摘 | GAUVREAU G M WATSON R M O'BYRNE P M | 1999 | Am J Respir Crit Care Med1999，160，2： | 1 |
| 4 | The percutaneous absorption of lead-203 in humans from cosmetic preparations containing lead acetate, as assessed by whole-body counting and other techniques 显示文摘 | Moore M Meredith P Watson W | 1980 | Food and Cosmetics Toxicology1980，18，： | 1 |
| 5 | Peanut hull pel- lets as a single use sorbent for the capture of Cu( Ⅱ )from wastewater 显示文摘 | Johnson P D Watson M A Brown J | 2002 | Waste Management2002，22，5： | 1 |
| 6 | Maturity indices for composted dairy and pig manures显示文摘 | P Wang C M Changa M E Watson | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 7 | Detection of specific polymerase chain reaction product by utilizing the 5′-3′exonoclease to thermos aquaticus DNA polymerase 显示文摘 | Holland P M Abramson R D Watson R | 1991 | Proc Natl Acd Sci USA1991，88，16： | 1 |
| 8 | Detection of specific polymerase chain reaction product by utilizing the 5 '3 ' exonucleas activity of the thermos aquaticus DNA polymerase显示文摘 | Holland P M Abramson R D Watson R | 1991 | Pro Nat Aca Sci USA1991，88，6： | 1 |
| 9 | Case series:Endoscopic management of fourth branchial arch anomalies显示文摘 | Watson GJ Nichani JR Rothera M P | 2013 | Int J Pediatr Oto- rhinolaryngol2013，77，5： | 1 |
| 10 | Investigations of Barium β- Diketonate Complexes Used in Chemical Vapour Deposition of High-Tc Oxide Films 显示文摘 | Watson I M Atwood M P Haq S | 1994 | Supercond Sci Technol1994，7，： | 1 |
| 11 | Plate tectonic history, basin development and petroleum source rock deposition onshore China显示文摘 | Watson M P Hayward A B Parkinson D N | 1987 | Marine and Petroleum Geology1987，4，： | 1 |
| 12 | Calculated optimal cooling rates for ram and human sperm cryopreservation fail to conform with empircal observations 显示文摘 | Curry M R Millar J D Watson P F | 1994 | Biol Reprod1994，51，： | 1 |
| 13 | Dental implant design effect on bone remodeling显示文摘 | Pilliar R M Deporter D A Watson P A | 1991 | J Biomed Mater Res1991，25，4： | 1 |
| 14 | Kinetics of aller- gen-induced airway eosinophilic cytokine production and air- way inflammation显示文摘 | Gauvreau G M Watson R M OByrne P M | 1999 | Am J Respir Crit Care Med1999，160，64： | 1 |
| 15 | Peanut hull pellets as a single use sorbent for the capture of Cu(Ⅱ) from wastewater显示文摘 | Johnson P D Watson M A Brown J | | 0，，03： | 1 |
| 16 | Copper-Catalyzed Enantioselective Additions to Oxocarbenium Ions: Alkynylation of Isochroman Acetals显示文摘 | Malty P Srinivas H D Watson M P | 2011 | Journal of the American Chemical Society2011，133，17： | 1 |
| 17 | Genotyping and phenotyping of platelet function disorders显示文摘 | Watson S P Lowe G C Lordkipanidze M | 2013 | J Thromb Haemost2013，11，1： | 1 |
| 18 | Identifia- ble factors in post-prostatectomy haemorrhage: the role of aspirin显示文摘 | Watson C J Deane A M Doyle P T | 1990 | BrJ Urol1990，66，： | 1 |
| 19 | A novel device for the collection,storage,transport and delivery of beneficial insects and its application to Ophraella communa (Coleoptera:Chrysomelidae)显示文摘 | Teshler M P Dernovic S A Di Tommaso A Coderre D Watson A K | 2004 | Biocontrol Science & Technology2004，14，： | 1 |
| 20 | A simple fluorogenic method to detect Vibrio cholerae and Aeromonas hydrophila in well water for areas impaeted by eatastrophie disasters显示文摘 | Richards G P Watson M A | 2006 | Am J Trop Med Hyg2006，75，： | 1 |
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