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| 1 | From blood to breath: New horizons for esophageal cancer biomarkers显示文摘Esophageal cancer is a lethal cancer encompassing adenocarcinoma and squamous cell carcinoma subtypes. The global incidence of esophageal cancer is increasing world-wide, associated with the increased prevalence of associated risk factors. The asymptomatic nature of disease often leads to late diagnosis and five-year survival rates of less than 15%. Current diagnostic tools are restricted to invasive and costly endoscopy and biopsy for histopathology. Minimally and non-invasive biomarkers of esophageal cancer are needed to facilitate earlier detection and better clinical management of patients. This paper summarises recent insights into the development and clinical validation of esophageal cancer biomarkers, focussing on circulating markers in the blood, and the emerging area of breath and odorant biomarkers. | Roger Yazbeck Simone E Jaenisch David I Watson | 2016 | World Journal of Gastroenterology2016，22，46： | 6 |
| 2 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 3 | PM 2.5 chemical source profiles for vehicle exhaust, vegetative burning, geological material, and coal burning in Northwestern Colorado during 1995显示文摘 | John G Watson Judith C Chow James E Houck | 2001 | Chemosphere2001，，8： | 2 |
| 4 | Genetic and environmental control of fruit maturation,dry matter and firmness in apple(Malus×domestica Borkh.)显示文摘For any given genotype,the environment in which an apple is grown can influence the properties of the fruit considerably.While there has been extensive research on the mechanism of the genetic control of fruit quality traits,less effort has been made to investigate the way that these genetic mechanisms interact with the environment.To address this issue,we employed a large‘Royal Gala’בBraeburn’population of 572 seedlings replicated over sites in three climatically diverse apple-growing regions in New Zealand.Phenotyping for traits including fruit maturation timing,firmness and dry matter content was performed at each of these three sites for a single growing season(2011),and at two sites(Motueka and Hawke’s Bay)for two seasons(2009 and 2010).The phenotype data collected over 2 years at two sites enabled the detection of 190 quantitative trait loci(QTL)that controlled these traits regardless of year or growing location,as well as some chromosomal loci that influenced the traits in a single given environment or year.For those loci that were environmentally stable over three sites,there was an interdependency of fruit maturation date,dry matter content and storage potential within this population,with two regions on Linkage Groups(LGs)10 and 16 strongly contributing.If these loci were used in a marker-assisted selection programme to select for progeny bearing firmer fruit,this would have the unintentional consequence of selecting,high dry matter content,later maturing apples.In addition,a further 113 new QTLs with a smaller effect were identified,some of which were exhibited only in a single growing environment,demonstrating the underlying complexity of control of traits determining fruit quality,in addition to the need for being aware of environmental effects when developing new apple varieties. | David Chagne Daya Dayatilake Robert Diack Murray Oliver Hilary Ireland Amy Watson Susan E Gardiner Jason W Johnston Robert J Schaffer Stuart Tustin | 2014 | Horticulture Research2014，1，1： | 2 |
| 5 | Rare-earth diffusion in zircon 显示文摘 | Cherniak D J Hanchar J M Watson E B | 1997 | Chemical Geology1997，134，4： | 1 |
| 6 | Endogenous opioids: biology and function 显示文摘 | Akil H Watson SJ Young E | 1984 | Annu Rev Neurosci1984，7，： | 1 |
| 7 | Continuous passive motion with accelerated flexion after total knee arthroplasty 显示文摘 | Yashar AA Venn Watson E Welsh T | 1997 | Clin Orthop1997，12，： | 1 |
| 8 | Maturity indices for composted dairy and pig manures显示文摘 | P Wang C M Changa M E Watson | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 9 | Mechanisms of thrombogenesis in atrial fibrillation:Virchow's triad revisited显示文摘 | Watson T Shantsila E Lip GY | 2009 | Lancet2009，373，9658： | 1 |
| 10 | Pb diffusion in zircon 显示文摘 | CHERNIAK D Jt WATSON E B | 2001 | Chemical Geology2001，，： | 1 |
| 11 | Individual kernel weight distri-bution of 12 varieties of hard red winter wheat 显示文摘 | C A Watson E G Heyne | 1977 | Ceral Chem1977，54，1： | 1 |
| 12 | Graphite fiber brush anodes for increased power production in air- cathode microbial fuel cells显示文摘 | Logan B E Cheng S Watson V | 2007 | Environ Sci Technol2007，41，9： | 1 |
| 13 | Nestle switches to vendor managed inventory with Tesco显示文摘 | Watson E | 2005 | Food Manufacture2005，80，8： | 1 |
| 14 | Approximate solutions for multi-location inventory systems with transshipments显示文摘 | Hu J Watson E Schneider H | 2005 | International Journal of Production Economics2005，97，1： | 1 |
| 15 | Pb diffusion in zircon 显示文摘 | Chemiak D J Watson E B | 2000 | Chemical Geology2000，172，12： | 1 |
| 16 | Identifying a randomly amplified polymorphic DNA(RAPD)marker linked to a gene for root-knot nematode resistance in sweetpotato显示文摘 | Ukoskit K Thompson P G Watson Jr C E | 1997 | J Am Soc Hort Sci1997，122，： | 1 |
| 17 | Altered estrogen receptor alpha and beta messenger RNA expression during human breast tumorigenesis显示文摘 | Leygue E Dotzlaw H Watson PH | 1998 | Cancer Res1998，58，15： | 1 |
| 18 | Diffusion in oscillatory pipe fow显示文摘 | Watson E | 1983 | J Fluid Mech1983，133，23： | 1 |
| 19 | Role of Self-Efficacy and Behavior Change显示文摘 | Halloway A Watson H E | 2002 | Int J Nurs Pract2002，8，2： | 1 |
| 20 | Dopamine agonis! therapy for neglect in humans显示文摘 | Fleet WS Valenstein E Watson RT | 1987 | Neurology1987，37，11： | 1 |
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