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| 1 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 2 | ACC/AHA 2008 Guidelines for the Management of Adults with Congenital Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Ouidelines (writing committee to develop guidelines on the management of adults with eongenital heart disease) 显示文摘 | Warnes CA Williams RG Bashore TM | 2008 | Circulation2008，118，23： | 1 |
| 3 | V-Src phosphorylation of connexin43 on Tyr247 and Tyr265 disrupts gap junction communication显示文摘 | RUI L BONNIE J WARN C | 2001 | The Journal of Cell Biology2001，154，4： | 1 |
| 4 | Production of measles nucleoprotein in different expression systems and its use as a diagnostic reagent显示文摘 | Warnes A Fooks A R Stephenson J R | 1994 | J Virol Meth1994，49，： | 1 |
| 5 | Can difference in soil community composition after peat meadow restoration lead to decomposition and mineralization rate显示文摘 | Vandijk J Van Didden Warn Kuenen F | 2009 | Soil Biology & Biochemistry2009，41，： | 1 |
| 6 | Variation in,and causes of,toxicity of cigarette butts to a cladoceran and microtox显示文摘 | Micevska T Warne MSJ Pablo F | | 0，，02： | 1 |
| 7 | Immune interferon inhibits prolifotation and induces 2'-5'-oligoademylate synthetase gene expression in human vascular smooth muscle cells显示文摘 | Warne SJ Friedman GB Libby P | 1989 | J Clin Invest1989，83，14： | 1 |
| 8 | Differentiation of DNA reactive and non - reactive genotoxic mechanisms using gene expression profile analysis 显示文摘 | DICKINSON D A WARNES G R QUIEVRYN G | 2004 | Murat Res2004，549，： | 1 |
| 9 | Clinical learning environment and supervision:Testing a research instrument in an international comparative study显示文摘 | Saarikoski M Kilpi HL Warne T | 2002 | Nurse Education Today2002，22，： | 1 |
| 10 | The risk of gallbladder cancer from polyps in a large multiethnic series 显示文摘 | Aldouri AQ Malik HZ Warn J | 2009 | Eur J Surg Oncol2009，35，1： | 1 |
| 11 | Optimizing the working life of hydrocarbon slurry pumps 显示文摘 | Cheryl Moreland Cliff Warne | 2007 | World Pumps2007，，9： | 1 |
| 12 | Growth in congenital hyperplasia显示文摘 | Nguyen An TT Brown JJ Warne GL | 2006 | Indian J Pediatr2006，73，1： | 1 |
| 13 | 查看详情显示文摘 | Singh A P Anderson C R Warnes J M | | 0，，05： | 1 |
| 14 | Four-week habituation to simulated barefoot running improves running economy when compared with shod running显示文摘 | Warne JP Warrington GD | | 0，，： | 1 |
| 15 | PIK3 CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer ceils to mTOR inhibitory drugs 显示文摘 | Weigeh B Warne PH Downward J | 2011 | Oncogene2011，30，29： | 1 |
| 16 | Improved aluminnide / MCrAlX coating systems for super alloys using CVD low activity aluminizing显示文摘 | Warnes B M | 2003 | Surface & Coatings Technology2003，，： | 1 |
| 17 | The toxicity and bioavailability of atrazine and molinate to Chironomus tepperi larvae in laboratory and river water in the presence and absence of sediment显示文摘 | PHYU Y L WARNE M S J LIM R P | 2005 | Chemosphere2005，58，： | 1 |
| 18 | Signal transduction by the TGF-beta superfamily显示文摘 | Attisano L Warne JL | 2002 | Science2002，296，5573： | 1 |
| 19 | Genotypic approaches to therapy in children: a national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children 显示文摘 | Ross C J Carleton B Warn DG | 2007 | Ann NY Acad Sci2007，1110，： | 1 |
| 20 | Risk based voltage security assessment显示文摘 | Warn H McCalley J D Vittal V | 2000 | IEEE Transactions on Power Systems2000，15，4： | 1 |
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