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| 1 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 2 | V-Src phosphorylation of connexin43 on Tyr247 and Tyr265 disrupts gap junction communication显示文摘 | RUI L BONNIE J WARN C | 2001 | The Journal of Cell Biology2001，154，4： | 1 |
| 3 | 查看详情显示文摘 | Singh A P Anderson C R Warnes J M | | 0，，05： | 1 |
| 4 | Genotypic approaches to therapy in children: a national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children 显示文摘 | Ross C J Carleton B Warn DG | 2007 | Ann NY Acad Sci2007，1110，： | 1 |
| 5 | Electromagnetic penetration of narrow slot apertures having depth显示文摘 | Warne L K Chen K C | 1988 | Interaction Note1988，464，： | 1 |
| 6 | Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue 显示文摘 | Warne J P John C D Christian H C | 2006 | Am J Physiol Endocrinol Metab2006，291，6： | 1 |
| 7 | Comparison of the outcome of porcine bioprosthetic versus mechanical prosthetic replacement of the tricuspid valve in the Ebstein anomaly显示文摘 | Brown M L Dearani J A Danielson G K Cetta F Connolly H M Warnes C A | 2009 | Am J Cardiol2009，103，： | 1 |
| 8 | Low pressure giant pulmonary artery aneurysms in the adult:natural history and management strategies显示文摘 | Veldtman G R Dearani J A Warnes C A | 2003 | Heart2003，9，9： | 1 |
| 9 | Minor stud- ies from the psychological laboratory of Cornell University: On the lapse of verbal meaning with repetition显示文摘 | BASSETT M F WARNE C J TITCHENER E B | 1919 | American Journal of Psyc- hology1919，30，4： | 1 |
| 10 | Clean diffusion coatings by chemi- cal vapor deposition 显示文摘 | Warnes B M Punola D C | 1997 | Surface and Coatings Technology1997，9495，： | 1 |
| 11 | ACC/AHA 2008 guidelines for management of adults with congenital heart disease 显示文摘 | WARNES C A WILLIAMS R G BASHORE T M | 2008 | Circulation2008，118，23： | 1 |
| 12 | Vertical stiffness of elastomeric and lead - rubber seismic isolation bearings 显示文摘 | Warn G P Whittaker A S Constantinou M C | 2007 | Journal of Structural Engineering2007，133，9： | 1 |
| 13 | Bioactivity of POPs and their effects in mosquitofish in Sydney Olympic Park,Australia显示文摘 | Rawson C Tremblay L Warne M | 2009 | Science of the Total Environment2009，407，12： | 1 |
| 14 | ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines on the Management of Adults With Congenital Heart Disease) Developed in Collaboration With the American Society of Eehocardiography, Heart Rhythm Society,International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons显示文摘 | Warnes C A Williams R G Bashore T M | 2008 | Journal of the American College of Cardiology2008，52，23： | 1 |
| 15 | Deletion of PDE2, the gene encoding the high-affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicans显示文摘 | Jung W H Warn P Ragni E Popolo L Nunn C D Turner M P | 2005 | Yeast2005，22，： | 1 |
| 16 | Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration,immunity and central nervous system infection:to die or not to die-that is the question显示文摘 | Rosello A Warnes G Meier U C | | 0，，01： | 1 |
| 17 | Verticalstiffness of elastomeric and lead-rubber seismic isolationbearings 显示文摘 | Warn G P Whittaker A S Constantinou M C | 2007 | Journal of Structural Engineering ASCE2007，133，9： | 1 |
| 18 | Equivalent antenna radius for narrow slot apertures having depth显示文摘 | Chen K C | 1989 | IEEE Transactions on Antennas and Propagation1989，37，7： | 1 |
| 19 | Low pressure giant pulmonary artery aneurysms in the adult:natural history and management strategies显示文摘 | Veldtman G R Dearani J A Warnes C A | 2003 | Heart2003，89，9： | 1 |
| 20 | Aspergillus flavus : human pathogen, allergen and mycotoxin producer显示文摘 | Hedayati M T Pasqualotto A C Warn P A | 2007 | Microbiol2007，153，6： | 1 |
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