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| 1 | Fluvastatin prevents renal injury and expression of lactin-like exidized low-density lipoprotein receptor-1 in rabbits with hypercholesterolemia显示文摘Background Lipid abnormalities are often complicated by renal dysfunction. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are the first-line choice for lowering cholesterol levels. The present study was designed to investigate whether statins could prevent and invert the development of renal injury in cholesterol-fed rabbits and to find the possible mechanism of their effects by detecting gene and protein expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the renal artery.Methods Twenty-four male New Zealand white rabbits were divided into three groups: (1) control group, regular granules chow; (2) HC-diet group, granules chow with 1% cholesterol and 5% lard oil; and (3) fluvastatin group, 1% cholesterol and 5% lard oil diet plus fluvastatin (10 mg·kg -1 ·d -1 ) . After 16 weeks, serum total cholesterol (TC), low-density lipoprotein(LDL) and creatinine (Cr) levels were measured. Renal hemodynamics and function, mainly including glomerular filtration rate (GFR) in vivo were quantified using 99m Tc-DTPA single photon emission computed tomograph ( 99m Tc-DTPA SPECT). The thickness of the renal artery intima was quantitated in HE-stained segments by histomorphometry. Gene expression of LOX-1 in the renal artery was examined by semi-quantitative RT-PCR and its protein expression was evaluated by immunohistochemistry.Results High cholesterol diet induced hypercholesterolemia (HC) complicated by renal dysfunction with increased levels of serum lipid and Cr, decreased GFR and delayed excretion and extensively thickened renal arterial intima in the HC-diet group. Rabbits in the control group showed a minimal LOX-1 expression (mRNA and protein) in the endothelium and neointima of the renal artery. Intimal proliferation of the renal artery in the HC-diet group was associated with a marked increase of LOX-1 expression (protein and mRNA). Treatment with fluvastatin improved renal function, attenuated intimal proliferation of the renal artery and markedly decreased the enhanced LOX-1 expression in the endothelium and neointima of the renal artery in rabbits. Conclusions Fuvastatin treatment could prevent the development of renal injury in patients with HC and early atherosclerosis (AS). This beneficial effect might be mediated by its pleiotropic effects including a decrease in total cholesterol exposure level and prevention of LOX-1 expression in atherosclerotic arteries. | YUYong-hui WANGYi DONGBo SUNShu-zhen CHENYao MENGXiao-hui LIUZhong-zhi | 2005 | Chinese Medical Journal2005，，8： | 11 |
| 2 | Geological Evolution and Huge Ore-Forming Belts in the Core Part of the Central Asian Metallogenic Region显示文摘The multi-stage geological evolution and extensive continental deformations during the course of its history make the Central Asian metallogenic region(CAMR) a unique and complicated large-scale metal domain. New geological observations and precise age-data allow an improved reconstruction of the geological evolution of the CAMR. This paper summarizes the Paleozoic orogenic evolution and related ore formation in the core part of the CAMR based on the geological data published both during the Soviet period and the last decades. Four ore-formation provinces(Altay, BalkhashJunggar, Chu-Yili-Tianshan, and Southwest Tianshan) could be classified. The Balkhash-Junggar and Chu-Yili-Tianshan provinces are the major topics of this paper. The Balkhash-Junggar province consists of 4 huge ore-forming belts(Zharma-Saur, Tarbahtay-Xiemistay, Aktogay-Baerluke, Balkhashwestern Junggar) with 11 large ore-college areas. The Chu-Yili-Tianshan province consists of 4 huge ore-forming belts(Alatau-Sairimu, Chu-Yili-Bolehuole, Issyk-Awulale, Kazharman-Nalaty) with 22 large ore-college areas. Formation of large ore-college area corresponds to a specific stage of continental crust growth. Comparison of geology and ore deposits in the CAMR provides rich information for future exploration and understanding of ore-forming processes. The Paleo-Junggar Ocean closed at Early Devonian in the Balkhash-western Junggar ore-forming belt. Afterwards, widespread volcanic- sedimentary rocks formed at extensional stage due to delamination of the thick lower crust formed during previous accretionary processes. Felsic magma intrusion caused formation of porphyry Cu-Au deposit at ~310 Ma and related hydrothermal gold deposits about 10 Ma later. For example, in the Hatu-Baobei-Sartohay Au-Cr ore-college area in the Balkhash-western Junggar ore-forming belt, small granitic to diorite plutons and various dykes(312–277 Ma) and large granite bodies(~300 Ma) intruded into the Devonian to Early Carboniferous volcano-sedimentary basin. These magmatic activities and fault systems mainly controlled ore-forming processes. | Yongfeng Zhu Fang An Wangyi Feng Huichao Zhang | 2016 | Journal of Earth Science2016，27，3： | 8 |
| 3 | EVOLUTION COMPL EXITY OF THE ELEMENTARY CELLULAR AUTOMATON OF RUL E 2 2显示文摘Cellular automata are the discrete dynamical systems of simple construction but with complex and varied behaviors.In this paper,the elementary cellular automaton of rule 22 is studied by the tools of formal language theory and symbolic dynamics.Its temporal evolution orbits are coarse grained into evolution sequences and the evolution languages are defined.It is proved that for every n ≥2 its width n evolution language is not regular. | WangYi JiangZhisong | 2002 | Applied Mathematics(A Journal of Chinese Universities)2002，17，4： | 7 |
| 4 | Cervical spinal canal narrowing and cervical neurological injuries显示文摘 | ZHANGLing CHENHai-bin WANGYi ZHANGLi-ying LIUJing-cheng WANGZheng-guo | 2012 | Chinese Journal of Traumatology2012，15，1： | 5 |
| 5 | Effect of ginsenoside Rgl and Rhl on the anti-tumor activity of dendritic cell显示文摘AIM: To study the effect of ginsenoside Rgl and Rhl on the anti - tumor activity of dendritic cells (DC). METHODS: Effect of Rgl and Rhl on the production of IL- 12 p40 protein was detected by ELISA, and the IL- 12 p40 mRNA level of DC was monitored by RT- PCR. Anti - tumor activity of DC- LPAK was detemnined by neutral red staining assay. RESULTS: The results of ELLSA showed that Rgl and Rhl significantly enhanced the production of IL- 12 p40 of DC. Rgl at 1 mg/L and Rhl at 100 mg/L upregulated the IL- 12 p40 mRNA level. Rgl and Rhl enhanced the anti - tumor ability of DC, induced lyrnphokine and PHA activated killer (DC-LPAK) on human papillate tumor cell line. Each dose of Rgl can obviously accelerate the eytotoxity to L929 at the E: T ratio of 5 : 1 (P<0.05,0.01 ), while only Rhl 10 mg/L enhanced the eytotoxity ability of DC- LPAK (P < 0.05). CONCLUSION: Rgl and Rhl enhanced the production of IL-12 p40. This effect may be mediated by the increase in the mRNA level. As a result, Rg1 and Rhl oromote the ability of DC to stimulate the cytotoxitie aetieity of DC - LPAK. | WANGYi HAOYu LOUJin-li MAHui QIUQuan-ying | 2004 | 中国病理生理杂志2004，20，10： | 3 |
| 6 | Lipidomics reveals association of circulating lipids with body mass index and outcomes in IgA nephropathy patients显示文摘IgA nephropathy(IgAN)is a leading cause of chronic kidney disease(CKD),which are commonly accompanied by dyslipidemia.Obesity is also associated with dyslipidemia and risk of CKD,but the relation of the dyslipidemia patterns with obesity and disease progression in IgAN patients remains unknown.Traditional Chinese medicine(TCM)and the combined treatment with corticosteroids and TCM have been shown to be of benefit for IgAN patients,but predictive markers for guiding these treatments are lacking.Here,we quantified 545 lipid species in the plasma from 196 participants,including 140 IgAN patients and 56 healthy volunteers,and revealed an altered plasma lipidome in IgAN patients as compared to healthy participants.Association analysis showed that a subgroup of glycerides,particularly triacylglycerols(TGs)containing docosahexaenoic acid,were positively associated with high body mass index(BMI)in under-or normal-weight IgAN patients,while several free fatty acids and sphingomyelins were positively associated with high BMI in overweight or obese IgAN patients.Further,our study suggested that elevated levels of eight lipids,mainly TG species containing linolenic acid,were independent risk factors for IgAN progression and also reported the prospective association of circulating lipids with treatment outcomes in IgAN.Taken together,our findings may not only help to achieve precision medicine but also provide a knowledge base for dietary intervention in the treatment of IgAN. | Yueyi Deng Qingqing Wu Wanjia Chen Li Zhu Wangyi Liu Fangying Xia Liang Sun Xu Lin Rong Zeng | 2021 | Journal of Molecular Cell Biology2021，13，8： | 2 |
| 7 | Stress corrosion cracking and its anisotropy of a PZT ferroelectric ceramics显示文摘Stress corrosion cracking (SCC) of a PZT ferroelectric ceramics in various media, such as moist atmosphere, silicon oil, methanol, water and formamide, and its anisotropy have been investigated at constant load test using a single-edge notched tensile specimen. The results showed that SCC could occur in all media, and the threshold stress intensity factor of SCC in water and formamide, KISCC, revealed anisotropy. The KISCC for poling direction parallel to the crack plane, was greater than that perpendicular to the crack plane, similar to the anisotropy of fracture toughness KIC; however, the anisotropy factor of KISCC, which was =1.8 (in formamide) and 2.1 (in water), was larger than that of KIC, which is =1.4. The stress-induced 90° domain switching causes the anisotropy of KIC and KISCC, besides, the resistance of SCC also has anisotropy. | WANGYi CHUWuyang SUYanjing GAOKewei QIAOLijie | 2003 | Chinese Science Bulletin2003，48，2： | 2 |
| 8 | InsitufabricationandthermoelectricpropertiesofPbTe-polyanilinecompositenanostructures显示文摘 | WangYY CaiKF YinJL etal | 2011 | JournalofNanoparticleResearch2011，13，2： | 1 |
| 9 | One-potfabricationandthermoelectric properties of Ag2 Te-polyanilinecore-shellnanostructures显示文摘 | WangYY CaiKF YinJL etal | 2012 | MaterialsChemistryandPhysics2012，133，2： | 1 |
| 10 | Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of martrix metalloproteinase Type1 : implication for diabetic nephropathy 显示文摘 | Mclenan SV WangYY Moreno V | 2004 | Endocrindogy2004，145，： | 1 |
| 11 | Energy Kuznets curve anempirical analysis of the developed countries [J]显示文摘 | LiuYang(刘扬) ChenShaofeng(陈劭锋) ZhangYunfang(张云芳) ZouXiuping(邹秀萍) WangYi(王毅) | | 中国管理科学0，，16： | 1 |
| 12 | Simulation of drop/impact rellability for electronic devices finite elementsin显示文摘 | WangYY LuC | | 0，，06： | 1 |
| 13 | Cytotoxicity of two new ribosome -inacti-vating proteins, cinnamomin and camphorin, to carcinoma cells 显示文摘 | LING Jun LIU Wangyi | 1996 | Cell Biochem Funct1996，14，： | 1 |
| 14 | 显示文摘 | XuJun(徐军) WanXian(万贤) ZhangBingqing(张冰清) WangYi(王懿) GuoBaohua(郭宝华) ZhangYanping(张寅平) WangXin(王馨) | 2009 | 髙分子学报2009，，11： | 1 |
| 15 | Anewalternatingminimizationalgorithmfortotalvariationimagereconstruction显示文摘 | WANGYilun YANGJunfeng YINWotao etal | 2008 | SIAM JournalonImagingSciences2008，1，3： | 1 |
| 16 | Converter Placement in Wavelength - routed Networks with Dynamic Traffic Demand 显示文摘 | Peiyuan Lee Xianzhong Wang Wangyi Gu Minli Zhou | 2007 | Journal of Optical Communications2007，28，1： | 1 |
| 17 | Flap side-edge noise mechanism and shape modification noise reduction design显示文摘 | HAN Xiao ZHOU Wangyi BAI Junqiang YU Peixun LI Yi SONG Xiang | 2018 | Chinese Journal of Acoustics2018，37，3： | 1 |
| 18 | Numerical simulation for the discharge behaviors of batteries in series and or parallel-connected battery pack 显示文摘 | Wu M S LinCY WangYY | 2006 | ElectrochimicaActa2006，52，3： | 1 |
| 19 | Effect of anaerobic reaction time on denitrifying phosphorus removal and N20 production 显示文摘 | WangYY GengJ J Ren Z J He W T Xing M Y Wu M Chen S W | 2011 | Bioresource Technology2011，102，10： | 1 |
| 20 | The simple and easy way to manufacture counter electrode for dye-sensitized solar cells 显示文摘 | LanJ L WangYY WanCC | 2010 | Cur- rent Appl Phys2010，10，2： | 1 |
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