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9篇 您的检索式：作者名="WangLM"

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		题名	作者	年代	出处	被引量
	1	Effects of wetland degradation on bacterial community in the Zoige Wetland of Qinghai-Tibetan Plateau(China)显示文摘	TANGJ DINGX WANGLM	2012	World J Microbiol Biotechnol2012，28，：	1
	2	Studyonyieldassessmentolodgingwinterwheatbasedonimagemanipulationandhyperspectralanalysis显示文摘	WuSR(吴尚蓉) LiuJ(刘佳) WangLM(王利民) eta1	2013	JournalofChinaAgriculturalResourcesandRegionalPlanning(中国农业资源与区划)2013，34，1：	1
	3	TherationaleoffeversurveillancetoidentifypatientswithsevereacuterespiratorysyndromeinTaiwan显示文摘	WangLM ChenYC TungSP etal	2006	EmergMedJ2006，23，3：	1
	4	Rapiddeterminationofplasmaconcentrationsoffourcommonlyusedsedativehypnoticsbysolidphaseextraction-HPLC显示文摘	WangLM	2004	临床医药实践2004，4，：	1
	5	Brain-derived neurotrophic factor and neural stem cells transplantation in treatment of hypoxie-ische-micbraininjuryinrats[J]显示文摘	WangHY ZhuXF WangLM	2008	中华儿科杂志2008，46，：	1
	6	Facile Yb (0Tf)3 promoted one-pot synthesis of polyhydroquinoline derivatives through Hantzsch reaction显示文摘	WangLM ShengJ Z HanJW		0，，06：	1
	7	胆红素含量测定方法改进[J]显示文摘	WANGLM(王亮明) Luw(路伟) WANGBN(王炳南) etal	1988	中成药研究1988，，4：	1
	8	Occurrence of sulfonamide and tetracycline-resistant bacteria and resistance genes in aquaculture environment显示文摘	GaoPP MaoDQ LuoY WangLM XuBJ XuL		0，，7：	1
	9	Identification of the key amino acids of glial cell line-derived neurotrophic factor family receptor alpha1 involved in its biological function显示文摘Glial cell line-derived neurotrophic factor (GDNF) plays a critical role in neurodevelopment and survival of midbrain dopaminergic and spinal motor neurons in vitro and in vivo. The biological actions of GDNF are mediated by a two-receptor complex consisting of a glycosylphosphatidylinositol-linked cell surface molecule, the GDNF family receptor alpha1 (GFRα1), and receptor protein tyrosine kinase Ret. Although structural analysis of GDNF has been extensively examined, less is known about the structural basis of GFRα1 function. In this study, based on evolutionary trace method and relative solvent accessibility prediction of residues, a set of trace residues that are solvent-accessible was selected for site-directed mutagenesis. A series of GFRα1 mutations was made, and PC12 cell lines stably expressing different GFRα1 mutants were generated. According to the survival and differentiation responses of these stable PC12 cells upon GDNF stimulation and the GDNF-GFRα1-Ret interaction assay, residues 152NN153, Arg259, and 316SNS318 in the GFRα1 central region were found to be critical for GFRα1 binding to GDNF and eliciting downstream signal transduction. The single mutation R259A in the GFRα1 molecule simultaneously lost its binding ability to GDNF and Ret. However N152A/N153A or S316A/N317A/S318A mutation in the GFRα1 molecule still retained the ability to bind with Ret. These findings suggest that distinct structural elements in GFRα1 may be involved in binding to GDNF and Ret.	WangLM ZhangQ ZhuW HeC LuCL DingDF ChenZY	2005	第二军医大学学报2005，26，7：	0

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