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| 1 | Effects of Matrine on Aconitine-Induced Electrophysiological Changes in Rat Ventricular Myocytes显示文摘Aim To explore the reason that the antiarrhythmic effect of the extract of traditional Chinese medicinal herb, matrine, is weaker than quinidine and verapamil by comparision of the effect and efficacy of matrine on various kinds of transmembrane ionic currents with those of quinidine and verapamil; and to demonstrate the best targets for antiarrhythinic drugs. Methods Whole-cell patch-clamp techniques were used to record the action potential and ionic currents in single cells of rat ventrictdar myocytes. Aconitine was used to induce the changes of ionic currents, then study the effects of matrine and quinidine, verapamil on aconitine-induced imbalanced channel currents and action potential. Results Aconitine 1μmol·L^-1 induced significant changes in transmembrane currents and action potential in single cells of rat ventricular myocytes. APD was significantly prolonged by aconitine. Simtdtaneously, aconitine increased sodium, L-type calcium and in-ward rectifier potassium currents. Matrine 100μmol·L^-1 reversed the aconitine-induced changes of sodium current (INa)from (-70.2±10.5) pA/pF to (-39.6±4.0) pA/pF (n=5, P<0.05 vs aconitine) ; L-type calcium current (ICa-L)from (20.4±3.8) pA/pF to (-12.9±2.9) pA/pF (n=6, P<0.01); the inward rectifier potassium current (IK1) from (-32.2±1.08) pA/pF to (-24.0±3.4) pA/pF (n=6, P<0.01 ), and action potential duration. The reversal effectsof quinidine and verapamil on aconitine-induced changes of APD and ionic currents were more marked than matrine. Conclusion Aco-nitine significantly disturbs the normal equilibrium of ion channels in ventricular myecytes. It induces changes of INa, ICa-L, IK1 and prolongation of action potential duration. Matrine at concentration 50 or 100μmol·L^-1 statistically significantly suppresses aconitine-induced changes of APD and ionic currents. The potency and efficacy of inhibitory effect of matrine are markedly weaker than those of commonly used verapamil and quinidine. | SHANHong-li YANGBao-feng ZHOUYu-hong WANGHe LIBao-xin | 2004 | Journal of Chinese Pharmaceutical Sciences2004，13，3： | 18 |
| 2 | The development of silicate matrix phosphors with broad excitation band for phosphor-convered white LED显示文摘This paper briefly reviews the recent progress in alkaline earth silicate host luminescent materials with broad excitation band for phosphor-convered white LED. Among them, the Sr-rich binary phases (Sr, Ba, Ca, Mg)2SiO4:Eu2+ and (Sr, Ba, Ca, Mg)3SiO5:Eu2+ are excellent phosphors for blue LED chip white LED. They have very broad excitation bands and exhibit strong absorption of blue radiation in the range of 450―480 nm. And they exhibit green and yellow-orange emission under the InGaN blue LED chip radiation, respectively. The luminous efficiency of InGaN-based (Sr, Ba, Ca, Mg)2SiO4:Eu2+ and (Sr, Ba, Ca, Mg)3SiO5:Eu2+ is about 70-80 lm/W, about 95%―105% that of the InGaN-based YAG:Ce, while the correlated color temperature is between 4600―11000 K. Trinary alkaline earth silicate host luminescent materials MO(M=Sr, Ca, Ba)-Mg(Zn)O-SiO2 show strong absorption of deep blue/near-ultraviolet radia- tion in the range of 370―440 nm. They can convert the deep blue/near-ultraviolet radiation into blue, green, and red emissions to generate white light. The realization of high-performance white-light LEDs by this approach presents excellent chromaticity and high color rendering index, and the application disadvantages caused by the mixture of various matrixes can be avoided. Moreover, the application prospects and the trends of research and development of alkaline earth silicate phosphors are also discussed. | LUO XiXian CAO WangHe SUN Fei | 2008 | Chinese Science Bulletin2008，53，19： | 9 |
| 3 | Up-conversion luminescence of Er^(3+) doped and Er^(3+)/Yb^(3+) co-doped YTaO_4显示文摘The synthesis and up-conversion luminescent properties of YTaO4:Er3+ and YTaO4:Er3+/Yb3+ are re- ported for the first time. According to the measurement results of up-conversion spectra, Yb3+ co-doping can remarkably enhance the green (2H11/2/4S3/2→4I15/2) and red (4F9/2→4I15/2) emissions, but de- press the infrared emission (4I9/2→4I15/2). With the increase of the Yb3+ concentration, the intensity of green emission increases, after that, when the Yb3+ concentration increases continuously, the intensity of green emission decreases, while those of the red and infrared emissions increase and decrease alternately. In addition, the up-conversion mechanisms of Er3+ doped and Er3+/Yb3+ co-doped YTaO4 are also discussed. It is found that the transform of up-conversion mechanism from two-step energy transfer to cooperating sensitization takes place when Yb3+ concentration is increased up to 12 mol%. With the further increase of Yb3+ concentration, the energy-back-transfer gradually becomes the dominant up-conversion mechanism, which results in the quenching of the green emission and slight increasing of the red and infrared emissions. | PANG Tao CAO WangHe | 2008 | Chinese Science Bulletin2008，53，2： | 6 |
| 4 | Preparation and characterization of monodisperse spherical particles of X-ray nano-phosphors based on Gd_2O_2S:Tb显示文摘Monodisperse spherical Gd2O2S:Tb nanoparticles have been prepared using an improved homogeneous precipitation method combined with solid-gas sulfuration technology. The effects of Tb3+-doped concentration on luminescent intensity and color purity of samples were investigated, and the optimal Tb3+-doped concentration was determined. Under the excitation of X-ray, the obtained sample shows excellent luminescent properties, and its luminescent intensity is increased by about 50% under lower sulfuration temperature compared with that of the Gd2O2S:Tb nanoparticles prepared by complex precipitation method. | XING MingMing CAO WangHe PANG Tao LING XiaoQiao CHEN Ning | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 5 | Involvement of chromatin and histone acetylation in the regulation of HIV-LTR by thyroid hormone receptor显示文摘The HIV-1 LTR controls the expression of HIV-1 viral genes and thus is critical for viral propagation and pathology. Numerous host factors have been shown to participate in the regulation of the LTR Promoter. Among them is the thyroid hormone (T3) receptor (TR). TR has been shown to bind to the critical region of the promoter that contain the NFkB and Sp1 binding sites. Interestingly, earlier transient transfection studies in tissue culture cells have yielded contradicting conclusions on the role of TR in LTR regulation, likely due to the use of different cell types and/or lack of proper chromatin organization. Here, using the frog oocyte as a model system that allows replication-coupled chromatin assembly, mimicking that in somatic cells, we demonstrate that unliganded heterodimers of TR and RXR (9-cis retinoic acid receptor) repress LTR while the addition of T3 relieves the repression and further activates the promoter. More importantly, we show that chromatin and unliganded TR/RXR synergize to repress the promoter in a histone deacetylase- dependent manner. | HsiaSC WangH | 2001 | Cell Research2001，11，1： | 4 |
| 6 | Blue,green,red upconversion luminescence and optical characteristics of rare earth doped rare earth oxide and oxysulfide显示文摘The cold isostatic press pretreatment process was adopted to prepare fine rare earth oxysulfide up-conversion phosphors with spherical shape, narrow size distribution and high luminescence efficiency. The upconversion optical characteristics and brightness of the blue (Y2O2SYb,Tm), green (Y2O2S: Yb,Er), red (Y2O3Yb,Er) emitter were also investigated, and a novel method was successfully developed for the brightness measurement of upconversion luminescence (UPL). It is shown that a white color can be obtained by the appropriate mixture of these primary blue, green and red emissions components. The Er3+ ions exhibit different upconversion mechanism in Y2O2S and Y2O3 host materials. The rare earth oxysulfide is an efficient upconversion matrix. The UPL brightness of Y2O2S: Yb,Er is 6.5 times higher than that of Y2O3: Yb,Er, and Y2O2S: Yb,Er shows UPL brightness of 1100 cd/m2 under 5.56 W/cm2 power density using a 980 nm laser diode. | LUO XiXian CAO WangHe | 2007 | Science China Chemistry2007，50，4： | 4 |
| 7 | Silica nanospheres formation induced by peroxidase-catalyzed phenol polymerization显示文摘To examine whether lignin-like compound is correlated with silica precipitation in grass, a series of simulated chemical experiments were carried out at ambient temperature and pressure, close to cell wall pH, with phenol polymerization catalyzed by peroxidase in silicon solution. The experiments showed that phenol polymer (a kind of lignin-like substance) caused silica nanosphere precipitation similar to those caused by protein in diatom cell wall previously reported by other authors. The sphere diameter varied with different kinds of phenol and the concentrations of phenol and silicon. Silicon precipitation had phenol and silicon saturation effect, meaning that when the concentration ratio of soluble silicon to phenol exceeded a certain value, the amount of silicon precipitation would decrease. | FANGJiangyu WANGHe CHENYangt ZHANGFusuo | 2003 | Progress in Natural Science:Materials International2003，13，7： | 3 |
| 8 | Characterization,virulence,and genetic variation of Rhizoctoria solani Ag-9 in Alberta显示文摘 | YANGJ KHARBANDAPD WANGH etal | 1996 | Plant Disease1996，80，： | 2 |
| 9 | Preinfarction angina preserves myocardial microcirculation and function after revascularization显示文摘Some studies suggest that patients with acute myocardial infarction (AMI) and preinfarction angina (PA) had smaller infarction size, better clinical outcome, less readmission and less mortality. However, the relationship between preinfarction angina and no-reflow has not yet been well investigated. 1-3 We hypothesized that patients with PA have a reduced no-reflow and better left ventricular function recovery after revascularization. The present study was aimed to evaluate myocardial perfusion after revascularization in patients with or without PA by using intravenous myocardial contrast echocardiography (MCE). | SHUXian-hong PANCui-zhen WANGHe HUANGGuo-qian CHENGLei-lei CHENHao-zhu | 2005 | Chinese Medical Journal2005，，13： | 2 |
| 10 | Preparation of transparent TiO_2 nanocrystalline film for UV sensor显示文摘nanocrystalline TiO_2 电影电极被大音阶的第五音胶化方法在不同锻烧的温度准备,它有不同电影厚度,一致透明性,以及光电的高度和机械稳定性的特征。光电的大小证明那锻烧的温度和电影厚度能显著地影响电极的光电的性质。在 450 deg C 锻烧的电影是有 highcrystallinity 和强壮的光电的活动的锐钛矿阶段,并且显示出最大的光电流。当温度比 450 deg C 低时,因为很多缺点,这部电影在这部电影有更弱的结晶度,并且这不为 pho-togenerated 搬运人的运输是有利的。并且在比 450 deg C 高的温度,电极的光电流被减少在这部电影的到期的 toanatase 金红石阶段转变。电影厚度的增加对紫外光的改进有利(紫外) 吸收总计,它将改进这部电影的光电的活动。但是,过多的厚度将在电极在减小增加 theelectron 洞对,和结果的再结合率“ s photoelectric 活动。另外,在电极生产的光电流的反应敏感和稳定性与偏爱潜力有关。在 0.4 V 的一个潜力,电极显示出 30.8 亩 Aand 的浸透的光电流 ~ 的一反应时间 1 s,建议准备 TiO_2 拍摄电极能被用于做紫外传感器。 | FU Yao CAO Wanghe | 2006 | Chinese Science Bulletin2006，51，14： | 2 |
| 11 | Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy显示文摘 | TianT WangY WangH | 2010 | J Cell Biochem2010，111，2： | 1 |
| 12 | Global,regional,andnationallevelsofneonatal,infant,andunder-5mortalityduring1990-2013:asystematicanalysisfortheGlobalBur-denofDiseaseStudy2013显示文摘 | WangH LiddellCA CoatesMM etal | 2014 | Lancet2014，384，9947： | 1 |
| 13 | Preparation of Incompact Strontium Aluminate Phosphors显示文摘The incompact long afterglow pigment SrAl2O4: Eu, Dy was synthesized by ceramics technology.The agglomerated starting raw material had little effect on the synthesis of SrA12O4 matrix through solid-state reaction method,but the shrinkage and densification was retarded greatly by the agglomerated powder by the formation of large and extensive pore network.The sintering mechanism is surface diffusion ( without flux B2O3 ) and grain boundary diffusion (with B2O3 as flux)respectively, and the as-prepared long afterglow pigment glows in the dark for over 4000 min. | Luo Xixian Xiao Zhiguo Xia Wei Cao Wanghe | 2004 | Journal of Rare Earths2004，22，z1： | 1 |
| 14 | Pyogenic liver abscess : a review of 10 years' experience in management 显示文摘 | Barakata MS Staphan MS Wangh RC | 1999 | Aust N Z J Surg1999，69，： | 1 |
| 15 | Effectiveness and limitations of uracil-DNA glycosylases in sensitive real-time PCR assays显示文摘 | Pierce KE Wangh LJ | 2004 | Biotechniques2004，36，1： | 1 |
| 16 | EffectofSionthedistributionofCdinriceseedlings显示文摘 | ShiXH ZhangCC WangH etal | 2005 | PlantSoil2005，272，： | 1 |
| 17 | Cu(OH)2- modified TiO2 nanotube arrays for efficient photocatalytic hydrogen production 显示文摘 | ZHANGSS WANGH J YUNG M S etal | 2013 | International Journal of Hydrogen Energy2013，38，18： | 1 |
| 18 | Lipoprotein lipase: from gene to obesity显示文摘 | WangH EckelRH | 2009 | Am J Physiol Endocrinol Metab2009，297，2： | 1 |
| 19 | Profilingof95microRNAsin pancreatic cancercelllines andsurgicalspecimensbyreal-timePCRanalysis显示文摘 | ZhangY LiM WangH etal | 2009 | WorldJSurg2009，33，4： | 1 |
| 20 | TLRsignalingnetworks:anintegrationofadaptormolecules,kinases,andcrosstalk显示文摘 | BrownJ WangH HajishengallisGN etal | 2011 | JournalofDentalResearch2011，90，4： | 1 |
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