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| 1 | Awareness and knowledge of hepatitis B infection and prevention and the use of hepatitis B vaccination in the Hong Kong adult Chinese population显示文摘背景肝炎 B 病毒( HBV )感染仍然是一个全球公共健康问题,它是尖锐、长期、暴发性的肝炎,肝肝硬化和在在在 10 点未改变的仍然是的过去的十年的香港的 HBV 感染的 hepatocellular carcinoma.The 流行的一个重要原因,尽管有实现通用新生并且当前的局势对 HBV 传播和预防的不适当的了解和知识可归因的成年 vaccination.We | Wah, Chung Pui Hung, Suen Sik Ka, Chan Oi Hsi, Lao Tzu Yeung, Leung Tak | 2012 | Chinese Medical Journal2012，，3： | 8 |
| 2 | 质子重离子肿瘤放疗的临床注册试验初步报告显示文摘目的探讨IONTRIS粒子放疗设备临床应用的安全性和有效性。方法2014年6月至2014年8月间共有35例肿瘤患者入组,其中男性31例,女性4例:年龄36~80岁,中位年龄69岁。头颈肿瘤10例(均为手术后复发),胸部肿瘤4例,原发性肝癌1例,腹膜后肉瘤术后复发1例.前列腺癌19例。碳离子照射剂量为2.74—10GyE/次,质子照射剂量为2—5.5GyE/次,5次/周。放疗前对每个放射野进行水箱剂量验证。结果碳离子照射22例,质子照射13例。放疗后1年,35例患者全部生存。在16例头颈部、胸部和腹盆腔肿瘤患者中,完全缓解2例,部分缓解1例,疾病稳定12例,疾病进展1例,1年无进展生存率为93.8%(15/16)。19例前列腺癌患者的1年无生化复发生存率为100%。35例患者对粒子放疗的耐受性良好,放疗期间的美国东部肿瘤协作组评分和体重无明显改变。25例(71.4%)患者发生了与粒子放疗相关的急性不良事件(AE)33例次,均为1级.在放疗1年时急性AE全部消失。有6例(17.1%)患者在放疗后1年发生后期AE6例次,全部为1级。结论采用IONTRIS设备治疗肿瘤患者安全、有效。 | 陆嘉德 叶明 郭小毛 傅深 Moyers F. Michael 章青 茅静芳 孔琳 HSI Wen Chien Shahnazi Kambiz 赵静芳 章真 马秀梅 来松涛 张晓萌 麻宁一 高云生 蔡昕 管西寅 张军华 吴斌 程竞仪 盛尹祥子 任炜 赵俊 孙力宁 蒋国梁 | 2018 | 中华肿瘤杂志2018，40，1： | 7 |
| 3 | SLS工艺参数对Al_2O_3/SiO_2/ZrO_2复合陶瓷烧结质量的影响显示文摘针对复合陶瓷材料Al2O3/SiO2/ZrO2脆性大难加工等问题,结合选择性激光烧结(SLS)工艺成形复合陶瓷粉末,采用Nd:YAG激光器及其送粉装置进行激光烧结试验.利用扫描电镜(SEM)、能量色散X射线光谱仪(EDX)和X射线衍射分析仪(XRD)观察了成形件的微观组织并分析了微观组织成分.探讨了激光烧结的主要工艺参数对单层烧结质量的影响及扫描速度对显微结构的影响.结果表明:采用正交试验方法系统地分析了工艺过程,获得最佳工艺参数为扫描速度15 mm/s、激光功率40 W、搭接量0.4 mm,得到了气孔较少、密度3.72 g/cm3的烧结表面,能够烧结出致密并具有枝状组织的陶瓷. | 王蔚 刘永贤 FUH Jerry Ying Hsi | 2013 | 东北大学学报(自然科学版)2013，34，3： | 5 |
| 4 | 免疫表型和分子遗传学方法对外周T/NK细胞淋巴瘤诊断的准确性:一项北美外周T/NK细胞淋巴瘤研究小组课题(英)显示文摘外周T细胞和NK细胞淋巴瘤诊断困难,对于必要的辅助检查项目几乎没有标准要求。该研究应用疫组化和分子遗传学特征分级的方式来评估一系列外周T细胞和NK细胞淋巴瘤的诊断方法,验证其诊断的准确性和临床相关性。7位血液病理学家评审了包括外周T细胞和NK细胞淋巴瘤及非外周T细胞和NK细胞淋巴瘤在内的374个病例的模拟诊断方法,每个病例分别由3名病理学家在HE染色和免疫组化的基础上分别进行诊断,诊断结果分级为0、1和2。诊断为2b级需要有基因重排分析数据,最终一致的诊断也需要在对每个病例进行讨论后确定。在所有374个病例中,诊断一致率为92.5%。 | Hsi ED 刘菊梅 | 2014 | 诊断病理学杂志2014，21，8： | 5 |
| 5 | 质子和碳离子治疗中CT值与相对阻止本领转换曲线的测量显示文摘目的 利用计算机断层扫描设备(CT)及质子重离子装置测量组织等效模体CT值与其对应的相对阻止本领转换曲线。方法 CT值与粒子阻止本领转换曲线在一定程度上决定了剂量计算的准确性。利用12个组织等效模体材料,经计算机断层扫描,获得其对应CT值,再利用质子重离子射线装置的质子、碳离子束流测量这些模体的相对阻止本领,从而获得CT值与质子、碳离子相对阻止本领转换曲线。结果 除肺等效模体以外,其他组织等效模体利用质子和碳离子束流测量得到的相对阻止本领之间的差异≤0.64%。结论 针对质子和碳离子束流,分别建立了基于等效模体测量的CT值-相对阻止本领转换曲线。 | 盛尹祥子 王巍伟 黄志杰 赵静芳 Wen Chien Hsi Kambiz Shahnazi | 2017 | 中华放射医学与防护杂志2017，37，9： | 4 |
| 6 | Investigation of process parameters of electrohydrodynamic jetting for 3D printed PCL fibrous scaffolds with complex geometries显示文摘Tissue engineering is a promising technology in the field of regenerative medicine with its potential to create tissues de novo.Though there has been a good progress in this field so far,there still exists the challenge of providing a 3D micro-architecture to the artificial tissue construct,to mimic the native cell or tissue environment.Both 3D printing and 3D bioprinting are looked upon as an excellent solution due to their capabilities of mimicking the native tissue architecture layer-by-layer with high precision and appreciable resolution.Electrohydrodynamic jetting(E-jetting)is one type of 3D printing,in which,a high electric voltage is applied between the extruding nozzle and the substrate in order to print highly controlled fibres.In this study,an E-jetting system was developed in-house for the purpose of 3D printing of fibrous scaffolds.The effect of various E-jetting parameters,namely the supply voltage,solution concentration,nozzle-to-substrate distance,stage(printing)speed and solution dispensing feed rate on the diameter of printed fibres were studied at the first stage.Optimized parameters were then used to print Polycaprolactone(PCL)scaffolds of highly complex geometries,i.e.,semi-lunar and spiral geometries,with the aim of demonstrating the flexibility and capability of the system to fabricate complex geometry scaffolds and biomimic the complex 3D micro-architecture of native tissue environment.The spiral geometry is expected to result in better cell migration during cell culture and tissue maturation. | Hui Wang Sanjairaj Vijayavenkataraman Yang Wu Zhen Shu Jie Sun Jerry Fuh Ying Hsi | 2016 | International Journal of Bioprinting2016，2，1： | 4 |
| 7 | Genome-wide DNA hypermethylation and homocysteine increase a risk for myopia显示文摘AIM: To test for the association between genome-wide methylation and myopia in human and mice. METHODS: Long interspersed nucleotide element 1(LINE-1) methylation levels were used to surrogate genome-wide methylation level. We first tested for the association between high myopia(<-6 D) and LINE-1 methylation in leukocytes in 220 cases and 220 control subjects. Secondly, we validated the results of LINE-1 methylation in eyes from the form deprivation myopia(FDM) mice. Furthermore,we calculated the correlation of LINE-1 methylation levels between leukocyte DNA and ocular DNA in the mice. We also tested whether dopamine can alter LINE-1 methylation levels. RESULTS: The LINE-1 methylation level was significantly higher in the myopic human subjects than controls. The upper and middle tertiles of the methylation levels increased an approximately 2-fold(P≤0.002) risk for myopia than the lower tertile. Similarly, FDM mice had high LINE-1 methylation levels in the leukocyte, retina and sclera, and furthermore the methylation levels detected from these three tissues were significantly correlated. Immunohistochemical staining revealed higher levels of homocysteine and methionine in the rodent myopic eyes than normal eyes. Dopamine treatment to the cells reduced both LINE-1 methylation and DNA methyltransferase levels. CONCLUSION: LINE-1 hypermethylation may be associated with high myopia in human and mice. Homocysteine and methionine are accumulated in myopic eyes, which may provide excess methyl group for genome-wide methylation. | Edward Hsi Yung-Song Wang Chia-Wei Huang Ming-Lung Yu Suh-Hang Hank Juo Chung-Ling Liang | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 4 |
| 8 | Biliopleural fistula: A rare complication of percutaneous transhepatic gallbladder drainage显示文摘A 79-year-old previously healthy man presented with acute acalculous cholecystitis with obstruction of the biliary tract. He was successfully treated with antibiotics and percutaneous transhepatic gallbladder drainage, but returned to the hospital two days after discharge with a rare complication of this technique, biliopleural fistula. A thoracostomy tube was inserted to drain the pleural effusion, and the patient’s previous antibiotics reinstated. After two weeks of drainage and antibiotics, the fistula healed spontaneously without the need for further intervention. | Ming-Tsung Lee Sheng-Chuan Hsi Philip Hu Kuang-Yi Liu | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 9 | 离线模式下PET/CT显像验证质子放疗精准度的模型实验显示文摘目的通过对聚甲基丙烯酸甲酯(PMMA)模体行离线模式下PET/CT显像,探讨PET-边界验证方法(PET-RV)用于定量分析质子放疗精准性的可行性。方法在PMMA模体上分别给予2 Gy和4 Gy的照射剂量,对每个剂量组根据临床靶区(CTV)的不同,以2.5 cm为步进分别设计7个照射深度组(5.0、7.5、10.0、12.5、15.0、17.5、20.0 cm),共14个照射计划(14组照射野)。以能量在48~221 MeV之间的质子束照射,照射结束后10 min左右进行PET/CT显像。对PET/CT数据分别进行图像配准、平滑和约化等预处理,然后利用Raystation PET-RV软件对图像进行感兴趣区(ROI)的确定和采样线的抽提,通过生成的预测感生放射性活度与实际采集感生放射性活度采样线计算ΔR50,即2条曲线末端在最大预测感生放射性活度最大值下降一半(V50)处对应的空间位置差异。结果每个照射野的ROI均为5.0 cm×5.0 cm×2.5 cm的立方体,采样线在其内间隔3 mm均匀分布,共得到289组采样线。14组数据经分析后得到的ΔR50(深度差异)均值都处于-1~1 mm之间。结论离线模式下PET/CT显像示PET-RV算法对PMMA模体质子放疗空间位置差异的验证精度在1 mm之内,可以满足后期对临床病例分析的精度要求。 | 张建岗 张俊昱 卢艳 盛尹祥子 任炜 施磊俊 孙筠 章英剑 Hsi Wenchien 周荣 蒋国梁 陆嘉德 程竞仪 | 2020 | 中华核医学与分子影像杂志2020，40，10： | 2 |
| 10 | Mercury adsorption properties of sulfur-impregnated adsorbents 显示文摘 | Hsi H Rood M J Abadi M R | 2002 | Journal of Environmental Engineering2002，128，11： | 1 |
| 11 | The 1998 enterovims 71 outbreak in Taiwan:pathogenesis and management显示文摘 | Lin T Chang L Hsis SH | 2002 | Clin infect Dis2002，34，2： | 1 |
| 12 | Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202) 显示文摘 | Rubenstein JL Hsi ED Johnson JL | 2013 | J Clin Oncol2013，31，25： | 1 |
| 13 | Calcified atherosclerosis in different vascular beds and the risk of mortality显示文摘 | Allison MA Hsi S Wassel CL | | 0，，01： | 1 |
| 14 | Aggregation of fuzzy options under group decision making 显示文摘 | Hsu Hsi Mei Chen Chen-Tung | 1996 | Fuzzy Sets and Systems1996，79，3： | 1 |
| 15 | Recycling of scrap cathode ray tubes 显示文摘 | Lee C H Hsi C S | 2002 | Environ Sci Technol2002，36，1： | 1 |
| 16 | Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11 ) (p21 ;q13 ) chromo- some translocation 显示文摘 | Davis IJ Hsi BL Arroyo JD | 2003 | Proc Natl Acad Sci USA2003，100，60： | 1 |
| 17 | Sugarcane ShSUT1 : analysis of sucrose transport activity and inhibition by sucralose 显示文摘 | REINDERS A SIVITZ A B HSI A | 2006 | Plant Cell and Environment2006，29，： | 1 |
| 18 | Recent developments in neuropsychological endophenotypes for schizophrenia: Development of the MATRICS battery, liability syndromes and the near future显示文摘Cognitive deficits are now recognized widely as core features of schizophrenia, and as major contributors to the clinical outcome of the disorder. They are also studied widely as 'endophenotypes', reflecting a growing consensus that schizophrenia is a broader, more multidimensional illness than the diagnostic criteria required for its formal diagnosis. This evolving view of cognition underlies its utilization in recent initiatives for intervention and assessment in schizophrenia. Two of these initiatives are reviewed in this paper. The first focuses on the development and validation of the MATRICS Cognitive Consensus Battery, a standardized battery of neuropsychological tests developed to assess the effectiveness of cognitive enhancing treatments in schizophrenia. A part of this effort includes the identification of performance-based, 'co-primary' measures of functional capacity that are related to cognition, and that are likely to show improvement at least partly as a function of improved cognition. The second initiative involves efforts to utilize neuropsychological deficits in the identification, validation and remediation of a liability syndrome for schizophrenia ('schizotaxia'). The discussion of this effort focuses on the development of a syndrome that is both measurable and meaningful clinically, and that may provide useful intervention targets. The utilization of cognition in both of these initiatives underscores its functional importance in the clinical outcome of schizophrenia. Moreover, it helps to illuminate indicators of liability for schizophrenia that might be amenable to remediation. | STONE William S HSI Xiaolu | 2011 | Chinese Science Bulletin2011，56，32： | 1 |
| 19 | Photodynamic therapy in the treatment of cancer 显示文摘 | Hsi R A Rosenthal D I Glastein E | 1999 | Drugs1999，57，5： | 1 |
| 20 | Prospective comparison of four laparoscopic vessel ligation devices显示文摘 | Lamberton GR Hsi RS Jin DH | 2008 | J Endourol2008，22，10： | 1 |
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