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| 1 | Mesenchymal stromal cells-exosomes:a promising cell-free therapeutic tool for wound healing and cutaneous regeneration显示文摘Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types,growth factors,extracellular matrix(ECM),nerves,and blood vessels.Mesenchymal stromal cells(MSCs)take part in all the skin wound healing stages playing active and beneficial roles in animal models and humans.Exosomes,which are among the key products MSCs release,mimic the effects of parental MSCs.They can shuttle various effector proteins,messenger RNA(mRNA)and microRNAs(miRNAs)to modulate the activity of recipient cells,playing important roles in wound healing.Moreover,using exosomes avoids many risks associated with cell transplantation.Therefore,as a novel type of cell-free therapy,MSC-exosome-mediated administration may be safer and more efficient than whole cell.In this review,we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous regeneration.In addition,we address the hypothesis of MSCs microenvironment extracellular vesicles(MSCs-MEVs)or MSCs microenvironment exosomes(MSCs-MExos)that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic applications.This review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration. | Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang Ubaldo Armato Ilaria Dal Prà Anna Chiarini | 2019 | Burns & Trauma2019，7，1： | 20 |
| 2 | Upregulation of Divalent Metal Transporter 1 (DMT1) Is Involved in Amyloid Precursor Protein Processing and Aβ Generation显示文摘The amyloid beta precursor protein (APP) and its pathogenic byproduct β-amyloid peptide (Aβ) play central roles in the pathogenesis of Alzheimer’s disease (AD). Reduction in | Wei Zheng , 1, Na Xin , 1, Zhi-Hong Chi , Jie Zhang , Bo-Lu Zhao , Jia-Yi Li , Zhan-You Wang , 2 Key Laboratory of Cell Biology, Ministry of Public Health of China, Laboratory of Cell Engineering, China Medical University, Shenyang, PR China State Key laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Academia Sinica, Beijing, PR China Department of Experimental Medical Science, Lund University, Sweden | 2009 | 生物物理学报2009，25，S1： | 8 |
| 3 | Preparation of nano-sized Bi_2Te_3 thermoelectric material powders by cryogenic grinding | Xiaozong Chen a, Leifeng Liu b, Yuan Dong a, Lianjun Wang a, Lidong Chen c, Wan Jiang a, a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 people of North Road, Shanghai 201620, PR China b Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden c Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, PR China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 8 |
| 4 | THE REACTION OF BENZOYL SUBSTITUTED HETEROCYCLIC KETENE AMINALS WITH ARYL AZIDES.A FACILE APPROACH TO SYNTHSIZE 1,5-DIARYL-4-(2-IMIDAZOLINYL)-1,2,3-TRIAZOLES显示文摘Heterocyclic ketene aminals 1 react with aryl azides 2 to give thetitled compounds 3,and in some cases also with the formation offused heterocycles 4. | Zhi Tang HUANG Mei Xiang WANG Institute of Chemistry,Academia Sinica,Beijing,PR of China | 1990 | Chinese Chemical Letters1990，1，1： | 3 |
| 5 | Effects of alloying and high-temperature heat treatment on the microstructure of Nb-Ti-Si based ultrahigh temperature alloys | Wang Mao,Xiping Guo State Key Laboratory of Solidification Processing,Northwestern Polytechnical University,Xi’an 710072,PR China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 2 |
| 6 | La_2O_3-Al_2O_3-SiO_2 glass-infiltrated 3Y-TZP all-ceramic composite for the dental restorative application | Shenyong Shi a, Qinghong Zhang b, Hongzhi Wang a, Yaogang Li b a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, PR China b Engineering Research Center of Advanced Glasses Manufacturing Technology, MOE, Donghua University, Shanghai 201620, PR China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 2 |
| 7 | Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFRI) 显示文摘 | Crisostomo PR Wang M Herring CM | 2007 | J Mol Cell Cardiol2007，42，1： | 1 |
| 8 | Organization of Escherichia coli O157 O antigen gene cluster and identification of its specific genes显示文摘 | Wang L Reeves PR | 1998 | Infect Immun1998，66，： | 1 |
| 9 | The relationship between health related quality of life and disease activity and damage in systemic lupus erythematosus显示文摘 | Wang C Mayo NE Fortin PR | 2001 | J Rheumatol2001，28，3： | 1 |
| 10 | Elevated neutrophil to lym- phocyte ratio predicts poor prognosis in nasopharyngeal carcinoma 显示文摘 | An X1 Ding PR Wang FH | 2011 | Tumour Biol2011，32，2： | 1 |
| 11 | Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-I in response to TNF by a p38 MAPK-dependent mechanism 显示文摘 | Wang M Crisostomo PR Herring C | 2006 | Am J Physiol Regul Integr Comp Physiol2006，291，4： | 1 |
| 12 | Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia 显示文摘 | Wang M Tsai BM Crisostomo PR | 2006 | Shock2006，25，5： | 1 |
| 13 | The Escherichia coli O111 and Salmonella enterica 035 gene clusters:gene clusters encoding the same colitose-containing O antigen are highly conserved显示文摘 | Wang L Reeves PR | 2000 | J Bacteriol2000，182，： | 1 |
| 14 | Involvement of multiple transcription factors in the regulation of steroidogenic acute regulatory protein gene expression 显示文摘 | Manna PR Wang XJ Stocco DM | 2003 | Steroids2003，68，14： | 1 |
| 15 | Endocarditis caused by Propionibacterium acnes: an easily ignored pathogen 显示文摘 | Pan SC Wang JT Hsueh PR | 2005 | Infect2005，51，4： | 1 |
| 16 | Outcome after temporary vascular occlusion for the management of renal trauma显示文摘 | Caroll PR McAnnich JW Wang A | 1994 | J Urol1994，151，： | 1 |
| 17 | High fat fed hamster, a unique animal model for treatment of diabetic dyslipidemia with peroxisome proliferator activated receptor alpha selective agonists 显示文摘 | Wang PR Guo Q Ippolito M | 2001 | Eur J Pharmacol2001，427，3： | 1 |
| 18 | Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-Ⅰ in response to TNF by a p38 MAPK- dependent mechanism显示文摘 | Wang M Crisostomo PR Herring C | 2006 | Am J Physiol Regul Integr Comp Physiol2006，291，4： | 1 |
| 19 | Potent inhibition of human telomerase by helenalin显示文摘 | Huang PR Yeh YM Wang TC | 2005 | Cancer Lett2005，227，2： | 1 |
| 20 | Reduction in natural death and renal failure from a systematic screening and treatment pro- gram in an Australian Aboriginal community 显示文摘 | Hoy WE Wang Z Baker PR | 2003 | Kidney Int Suppl2003，，83： | 1 |
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