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| 1 | Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. | Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen | 2020 | Science China(Life Sciences)2020，63，5： | 77 |
| 2 | Phosphorus recovery from biogas fermentation liquid by Ca-Mg loaded biochar显示文摘Shortage in phosphorus(P) resources and P wastewater pollution is considered as a serious problem worldwide. The application of modified biochar for P recovery from wastewater and reuse of recovered P as agricultural fertilizer is a preferred process. This work aims to develop a calcium and magnesium loaded biochar(Ca–Mg/biochar) application for P recovery from biogas fermentation liquid. The physico-chemical characterization, adsorption efficiency, adsorption selectivity, and postsorption availability of Ca-Mg/biochar were investigated. The synthesized Ca–Mg/biochar was rich in organic functional groups and in Ca O and Mg O nanoparticles. With the increase in synthesis temperature, the yield decreased, C content increased, H content decreased, N content remained the same basically, and BET surface area increased. The P adsorption of Ca–Mg/biochar could be accelerated by nano-Ca O and nano-Mg O particles and reached equilibrium after 360 min.The process was endothermic, spontaneous, and showed an increase in the disorder of the solid–liquid interface. Moreover, it could be fitted by the Freundlich model. The maximum P adsorption amounts were 294.22, 315.33, and 326.63 mg/g. The P adsorption selectivity of Ca–Mg/biochar could not be significantly influenced by the typical p H level of biogas fermentation liquid. The nano-Ca O and nano-Mg O particles of Ca–Mg/biochar could reduce the negative interaction effects of coexisting ions. The P releasing amounts of postsorption Ca–Mg/biochar were in the order of Ca–Mg/B600 > Ca–Mg/B450 > Ca–Mg/B300. Results revealed that postsorption Ca–Mg/biochar can continually release P and is more suitable for an acid environment. | Ci Fang Tao Zhang Ping Li Rongfeng Jiang Shubiao Wu Haiyu Nie Yingcai Wang | 2015 | Journal of Environmental Sciences2015，27，3： | 21 |
| 3 | Comparison of Headspace Solid-Phase Microextraction with Simultaneous Steam Distillation Extraction for the Analysis of the Volatile Constituents in Chinese Apricot显示文摘Volatile constituents in fully mature fruits of apricot (Prunus armeniaca L.) cultivar Xinshiji were extracted using headspace solid-phase microextraction (HS-SPME) and simultaneous steam distillation extraction (SSDE) and then analyzed using capillary gas chromatography and gas chromatography-mass spectrometry. A total of 70 components were identified by HS- SPME, including 20 esters, 19 hydrocarbons, 5 alcohols, 5 ketones, 4 acids, 4 lactones, 3 aldehydes, and 10 miscellaneous components, with the esters being the dominant constituent. On the basis of the odor unit values, it is believed that the following compounds probably contributed to the fresh apricot odor: hexyl acetate, β-ionone, butyl acetate, (E)-2-hexenal, linalool, limonene, γ-decalactone, and hexanal. A total of 49 components were also detected by SSDE, including 13 hydrocarbons, 9 alcohols, 7 aldehydes, 9 esters, 4 ketones, 4 lactones, 2 acids, and 1 miscellaneous component, of which the monoterpene alcohols were the dominant constituents. It could be judged from the odor unit values that the following compounds were the major contributors to boiled apricot aroma: β-ionone, linalool, hexyl acetate, γ-dodecalactone, γ- decalactone, (E)-2-hexenal, hexanal, γ-octalactone, phenylacetaldehyde, butyl acetate, limonene, α-terpineol, and δ-decalactone. The results show that HS-SPME is a simple, rapid, and solvent-free method, which is an alternative to the classical SSDE. | CHEN Mei-xia CHEN Xue-sen WANG Xin-guo CI Zhi-juan LIU Xiao-li HE Tian-ming ZHANG Li-jie | 2006 | Agricultural Sciences in China2006，5，11： | 20 |
| 4 | COVID-19: Challenges to GIS with Big Data显示文摘The outbreak of the 2019 novel coronavirus disease(COVID-19)has caused more than 100,000 people infected and thousands of deaths.Currently,the number of infections and deaths is still increasing rapidly.COVID-19 seriously threatens human health,production,life,social functioning and international relations.In the fight against COVID-19,Geographic Information Systems(GIS)and big data technologies have played an important role in many aspects,including the rapid aggregation of multi-source big data,rapid visualization of epidemic information,spatial tracking of confirmed cases,prediction of regional transmission,spatial segmentation of the epidemic risk and prevention level,balancing and management of the supply and demand of material resources,and socialemotional guidance and panic elimination,which provided solid spatial information support for decision-making,measures formulation,and effectiveness assessment of COVID-19 prevention and control.GIS has developed and matured relatively quickly and has a complete technological route for data preparation,platform construction,model construction,and map production.However,for the struggle against the widespread epidemic,the main challenge is finding strategies to adjust traditional technical methods and improve speed and accuracy of information provision for social management.At the data level,in the era of big data,data no longer come mainly from the government but are gathered from more diverse enterprises.As a result,the use of GIS faces difficulties in data acquisition and the integration of heterogeneous data,which requires governments,businesses,and academic institutions to jointly promote the formulation of relevant policies.At the technical level,spatial analysis methods for big data are in the ascendancy.Currently and for a long time in the future,the development of GIS should be strengthened to form a data-driven system for rapid knowledge acquisition,which signifies ts that GIS should be used to reinforce the social operation parameterization of models and methods,especially when providing support for social management. | Chenghu Zhou Fenzhen Su Tao Pei An Zhang Yunyan Du Bin Luo Zhidong Cao Juanle Wang Wen Yuan Yunqiang Zhu Ci Song Jie Chen Jun Xu Fujia Li Ting Ma Lili Jiang Fengqin Yan Jiawei Yi Yunfeng Hu Yilan Liao Han Xiao | 2020 | Geography and Sustainability2020，1，1： | 13 |
| 5 | Soil Organic Carbon Mineralization as Affected by Cyclical Temperature Fluctuations in a Karst Region of Southwestern China显示文摘The diurnal fluctuation in soil temperature may influence soil organic carbon(SOC) mineralization, but there is no consensus on SOC mineralization response to the cyclical fluctuation in soil temperature. A 56-d incubation experiment was conducted to investigate the effects of constant and variable temperatures on SOC mineralization. Three soils were collected from the karst region in western Guizhou Province, southwestern China, including a limestone soil under forest, a limestone soil under crops and a yellow soil under crops. According to the World Reference Base(WRB) classification, the two limestone soils were classified as Haplic Luvisols and the yellow soil as a Dystric Luvisol. These soils were incubated at three constant temperatures(15, 20 and 25?C) and cyclically fluctuating temperatures(diurnal cycle between 15 and 25?C). The results showed that the 56-d cumulative SOC mineralized(C56)at the fluctuating temperatures was between those at constant 15 and 25?C, suggesting that the cumulative SOC mineralization was restricted by temperature range. The SOC mineralization responses to the fluctuating temperatures were different among the three soils, especially in contrast to those at constant 20?C. Compared with constant 20?C, significant(P < 0.05) decreases and increases in C56 value were found in the limestone soil under forest and yellow soil under crops at the fluctuating temperatures, respectively. At the fluctuating temperatures, the forest soil with lower temperature coefficient Q10(the relative change in SOC mineralization rate as a result of increasing the temperature by 10?C) had a significantly(P < 0.05) lower SOC mineralization intensity than the two cropland soils. These indicated that differences in temperature pattern(constant or fluctuating) could significantly influence SOC mineralization, and SOC mineralization responses to the fluctuating temperatures might be affected by soil characteristics.Moreover, the warmer temperatures might improve the ability of soil microbes to decompose the recalcitrant SOC fraction, and cyclical fluctuations in temperature could influence SOC mineralization through changing the labile SOC pool size and the mineralization rate of the recalcitrant SOC in soils. | CI En Mahdi M.AL-KAISI WANG Liange DING Changhuan XIE Deti | 2015 | Pedosphere2015，25，4： | 12 |
| 6 | Controlled Nanocutting of Graphene显示文摘Rapid progress in graphene-based applications is calling for new processing techniques for creating graphene components with different shapes,sizes,and edge structures.Here we report a controlled cutting process for graphene sheets,using nickel nanoparticles as a knife that cuts with nanoscale precision.The cutting proceeds via catalytic hydrogenation of the graphene lattice,and can generate graphene pieces with specifi c zigzag or armchair edges.The size of the nanoparticle dictates the edge structure that is produced during the cutting.The cutting occurs along straight lines and along symmetry lines,defined by angles of 60ºor 120º,and is defl ected at free edges or defects,allowing practical control of graphene nano-engineering. | Lijie Ci Zhiping Xu Lili Wang Wei Gao Feng Ding Kevin F.Kelly Boris I.Yakobson Pulickel M.Ajayan | 2008 | Nano Research2008，1，2： | 11 |
| 7 | Building a Cloud-Based Energy Storage System through Digital Transformation of Distributed Backup Battery in Mobile Base Stations显示文摘Battery energy storage systems(ESS) have been widely used in mobile base stations(BS) as the main backup power source. Due to the large number of base stations, massive distributed ESSs have largely stayed in idle and very difficult to achieve high asset utilization. In recent years, the fast-paced development of digital energy storage(DES) technology has revolutionized the traditional operation and maintenance of ESSs by transforming them into digital assets, further enabling battery energy storage services, raising up a new way to achieve a much higher utilization of such kind of largely idle ESS resources. In this paper, the disruptive DES technology will be introduced and its application under the context of mobile BSs will be studied, and then a cloud-based energy storage(CES) platform is proposed based on a large scale distributed DESs to provide a new cyber-enabled energy storage service to the local utility company. A real-world case study shows the effectiveness and efficiency of the CES platform. | Song Ci Yanglin Zhou Yuan Xu Xingjian Diao Junwei Wang | 2020 | China Communications2020，17，4： | 10 |
| 8 | Mercury in leaf litter in typical suburban and urban broadleaf forests in China显示文摘To study the role of leaf litter in the mercury (Hg) cycle in suburban broadleaf forests and the distribution of Hg in urban forests, we collected leaf litter and soil from suburban evergreen and deciduous broadleaf forests and from urban forests in Beijing. The Hg concentrations in leaf litter from the suburban forests varied from 8.3 to 205.0 ng/g, with an average (avg) of (49.7 ± 36.9) ng/g. The average Hg concentration in evergreen broadleaf forest leaf litter (50.8 ± 39.4) ng/g was higher than that in deciduous broadleaf forest leaf litter (25.8 ± 10.1) ng/g. The estimated Hg fluxes of leaf litter in suburban evergreen and deciduous broadleaf forests were 179.0 and 83.7 mg/(ha·yr), respectively. The Hg concentration in organic horizons (O horizons) ((263.1 ± 237.2) ng/g) was higher than that in eluvial horizons (A horizons) ((83.9 ± 52.0) ng/g). These results indicated that leaf litterfall plays an important role in transporting atmospheric mercury to soil in suburban forests. For urban forests in Beijing, the Hg concentrations in leaf litter ranged from 8.8-119.0 (avg 28.1 ± 16.6) ng/g, with higher concentrations at urban sites than at suburban sites for each tree. The Hg concentrations in surface soil in Beijing were 32.0-25300.0 ng/g and increased from suburban sites to urban sites, with the highest value from Jingshan (JS) Park at the centre of Beijing. Therefore, the distribution of Hg in Beijing urban forests appeared to be strongly influenced by anthropogenic activities. | Zhenchuan Niu Xiaoshan Zhang Zhangwei Wang Zhijia Ci | 2011 | Journal of Environmental Sciences2011，23，12： | 9 |
| 9 | Synthesis of magnetic polyphosphazene-Ag composite particles as surface enhanced Raman spectroscopy substrates for the detection of melamine显示文摘Magnetic polyphosphazene(MPZS) particles coated by Ag nanoparticles(MPZS-Ag) have been developed as surface enhanced Raman spectroscopy(SERS) substrates for sensitive detection of melamine in aqueous solutions and milk samples.5,5’-Dithiobis-(2-nitrobenzoic acid)(DTNB) was used as model analyte to test the SERS activity of the MPZS-Ag particles.The prepared MPZS-Ag particles possess both magnetic responsiveness and excellent SERS properties.SERS detection of different concentrations of melamine aqueous solutions and spiked milk samples were performed by the MPZS-Ag particles.The limit of detection(LOD) of the melamine in aqueous solutions was 10^-7 mol/L(0.0126 mg/L) and 0.6 mg/L in real milk samples using the MPZS-Ag particles as SERS substrates.The LOD of the melamine are much lower than the safety values of Food and Drug Administration and Codex Alimentarius Commission.These results indicate that the MPZS-Ag particles have promising application prospect for SERS analysis in food safety fields. | Ci Huang Feifei Lu Ke Xu Guanjun Ding Lijun You Jiabin Wang Qiqing Zhang | 2019 | Chinese Chemical Letters2019，30，12： | 6 |
| 10 | Factors related to improved American Spinal Injury Association grade of acute traumatic spinal cord injury显示文摘BACKGROUND Acute traumatic spinal cord injury(ATSCI)usually results in disability,yet data on contemporary national trends of ATSCI incidence are limited.AIM To provide a systematic and basic theoretical basis for improving the treatment of acute spinal cord injury.METHODS Data from the Peking University Third Hospital Inpatient Sample databases were analyzed.A total of 304 patients with ATSCI were included from 2012 to 2017.The epidemiological data,treatment,complications and clinical outcomes of these patients were reviewed.RESULTS Of the 304 patients,257(84.5%)were male,and 75%of the patients were 55 years old or younger.135 patients had improved follow-up American Spinal Injury Association(ASIA)grades(44.4%).Only 14 patients with ASIA grade A improved.A statistically significant difference in prognosis between patients who underwent surgery within 72 h and those who underwent surgery after 72 h was observed(P<0.05).Surgery within 72 h resulted in better prognosis.The Steroid group and the Non-Steroid group showed a significant difference in outcome among patients with ASIA grades A and B(P<0.05).Patients with pneumonia had a poorer prognosis than patients without pneumonia(P<0.05).Surgery within 72 h resulted in better prognosis.CONCLUSION This study found that there was no significant difference in hospitalization time and prognosis between the Steroid group and the Non-Steroid group,but the patients with severe spinal cord injury(ASIA grades A and B)who underwent surgery combined with steroid therapy had a better prognosis than those who underwent surgery alone.The disastrous consequences of ATSCI and lack of consensus on the management strategy are obvious.Further improvements in treatment planns are needed in order to obtain more reliable functional outcomes. | Ci Tian Yang Lv Shu Li Dai-Dai Wang Yi Bai Fang Zhou Qing-Bian Ma | 2020 | World Journal of Clinical Cases2020，8，20： | 5 |
| 11 | Tuning F-doped degree of rGO:Restraining corrosion-promotion activity of EP/rGO nanocomposite coating显示文摘Given that graphene features high electrical conductivity,it is a kind of material with corrosion-promotion activity.This study aimed to inhibit the corrosion-promotion activity of graphene in coatings.Here,we report an exciting application of epoxy matrix(EP)/F-doped reduced graphene oxide(rGO)coatings for the long-term corrosion protection of steel.The synthesized F-doped rGO(FG)did not reduce the utilization of rGO by a wide margin and possessed distinctive electrically insulating nature.The electrical conductivity of rGO was approximately 1500 S/m,whereas those of FG-1,FG-2 and FG-3 were 1.17,5.217×10^−2 and 3.643×10^-11 S/m,respectively.FG and rGO were then dispersed into epoxy coatings.The chemical structures of rGO and FG were investigated by transmission electron microscopy(TEM),scanning probe microscopy(SPM),X-ray photoelectron spectroscopy(XPS),Fourier-transform infrared spectroscopy(FTIR),and X-ray diffraction(XRD).EP/FG coatings exhibited outstanding corrosion protection in comparison with blank EP and EP/rGO coatings mainly because the corrosion-promotion effect of rGO was eliminated.The anticorrosion ability of EP/FG coatingswasimproved with increased F-doped degree of FG.In addition,electrochemical impendance spectroscopy(EIS)results indicated that the Rc values of EP/FG-2 and EP/FG-3 were four orders of magnitude higher than those of EP/rGO in diluent NaCl solution(3.5 wt.%)after immersion for 90 days. | Lu Shen Yong Li Wenjie Zhao Kui Wang Xiaojing Ci Yangmin Wu Gang Liu Chao Liu Zhiwen Fang | 2020 | Journal of Materials Science & Technology2020，44，9： | 5 |
| 12 | Topology-aware virtual network embedding based on closeness centrality显示文摘 | Zihou WANG Yanni HAN Tao LIN Yuemei XU Song CI Hui TANG | 2013 | Frontiers of Computer Science2013，7，3： | 5 |
| 13 | Monitoring the Amery Ice Shelf front during 2004-2012 using ENVISAT ASAR data显示文摘The Amery Ice Shelf is the largest ice shelf in East Antarctica. It drains continental ice from an area of more than one million square kilometres through a section of coastline that represents approximately 2% of the total circumference of the Antarctic continent. In this study, we used a time series of ENVISAT ASAR images from 2004-2012 and flow lines derived from surface velocity data to monitor the changes in 12 tributaries of the Amery Ice Shelf front. The results show that the Amery Ice Shelf has been expanding and that the rates of expansion differ across the shelf. The highest average annual rate of advance from 2004-2012 was 3.36 m·d-1 and the lowest rate was 1.65 m·d-1 . The rates in 2009 and 2010 were generally lower than those in other years. There was a low correlation between the rate of expansion and the atmospheric temperature recorded at a nearby research station, however the mechanism of the relationship was complex. This study shows that the expansion of the Amery Ice Shelf is slowing down, reflecting a changing trend in climate and ice conditions in East Antarctica. | ZHAO Chen CHENG Xiao HUI Fengming KANG Jing LIU Yan WANG Xianwei WANG Fang CHENG Cheng FENG Zhunzhun CI Tianyu ZHAO Tiancheng ZHAI Mengxi | 2013 | Advances in Polar Science2013，24，2： | 4 |
| 14 | ia-PNCC: Noise Processing Method for Underwater Target Recognition Convolutional Neural Network显示文摘Underwater target recognition is a key technology for underwater acoustic countermeasure.How to classify and recognize underwater targets according to the noise information of underwater targets has been a hot topic in the field of underwater acoustic signals.In this paper,the deep learning model is applied to underwater target recognition.Improved anti-noise Power-Normalized Cepstral Coefficients(ia-PNCC)is proposed,based on PNCC applied to underwater noises.Multitaper and normalized Gammatone filter banks are applied to improve the anti-noise capacity.The method is combined with a convolutional neural network in order to recognize the underwater target.Experiment results show that the acoustic feature presented by ia-PNCC has lower noise and are wellsuited to underwater target recognition using a convolutional neural network.Compared with the combination of convolutional neural network with single acoustic feature,such as MFCC(Mel-scale Frequency Cepstral Coefficients)or LPCC(Linear Prediction Cepstral Coefficients),the combination of the ia-PNCC with a convolutional neural network offers better accuracy for underwater target recognition. | Nianbin Wang Ming He Jianguo Sun Hongbin Wang Lianke Zhou Ci Chu Lei Chen | 2019 | Computers, Materials & Continua2019，，1： | 3 |
| 15 | Demographic history of the Tibetan antelope Pantholops hodgsoni(chiru)显示文摘The Tibetan antelope(chiru,Pantholops hodgsoni),a heavily poached species and symbol of the QinghaiTibetan Plateau(QTP),is noted worldwide for its special calving migration.This species originated in the early Quaternary and it is interesting to know how the following climatic oscillations affected its demographic dynamics in the climate-sensitive QTP.In this study,we analyzed the mitochondrial D-loop region from 312 individuals sampled in all of the six major populations.We found high rates of gene flow and little genetic differentiation between populations,suggesting that the calving migration may have homogenized the genetic pool of this species.Both mismatch distribution analyses and coalescent simulations suggested that this species experienced a demographic expansion approximately 600-200 Kyr following the retreat of the large glaciers developed in the QTP at 800-600 Kyr,rather than at the end of the last glacial age,as previously suggested,based on a limited sample size.In addition,we found evidence of a chiru population decrease probably related to the human settings at the QTP during the middle Holocene. | Yu-Rong DU Song-Chang GUO Zhao-Feng WANG Hai-Xing CI Zhen-Yuan CAI Qian ZHANG Jian-Ping SU Jian-Quan LIU | 2010 | Journal of Systematics and Evolution2010，48，6： | 3 |
| 16 | Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis显示文摘Major evolutionary transitions are enigmas,and the most notable enigma is between invertebrates and vertebrates,with numerous spectacular innovations.To search for the molecular connections involved,we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans.We focused on gametes and early embryos,where the methylomes are known to evolve divergently between fish and mammals.Here,we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects,but clearly presents in deuterostomes such as echinoderms and invertebrate chordates,and then becomes more evident in vertebrates.Functional association analysis suggests that DNA methylation reprogramming is associated with development,reproduction and adaptive immunity for vertebrates,but not for invertebrates.Interestingly,the single HOX cluster of invertebrates maintains unmethylated status in all stages examined.In contrast,the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis.Notably,the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals.Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution,especially after the evolutionary transitions from invertebrates to vertebrates,and then to mammals. | Xiaocui Xu Guoqiang Li Congru Li Jing Zhang Qiang Wang David KSimmons Xuepeng Chen Naveen Wijesena Wei Zhu Zhanyang Wang Zhenhua Wang Bao Ju Weimin Ci Xuemei Lu Daqi Yu Qian-fei Wang Neelakanteswar Aluru Paola Oliveri Yong EZhang Mark QMartindale Jiang Liu | 2019 | National Science Review2019，6，5： | 2 |
| 17 | Early T-cell precursor leukemia:a subtype of high risk childhood acute lymphoblastic leukemia显示文摘Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia(T-ALL)and B-cell acute lymphoblastic leukemia(B-ALL).In children,T-ALL usually has a worse prognosis than B-ALL,although childhood T-ALL prognoses have improved remarkably.The varying outcomes among T-ALL cases suggest that an unrecognized biological heterogeneity may contribute to chemo-resistance.Deep exploration of T-lymphocyte development in recent years has found a subgroup of patients with a phenotype that resembles early T-cell precursor,which confers a much poorer prognosis than any other form of T-ALL.This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia(ETP-ALL).Flow cytometry data from T-ALL patients enrolled in Shanghai Children’s Medical Center between July 2002 and October 2010 were assessed according to Dr.Campana’s protocol.Among total 89 T-ALL cases,74 cases had enough immunophenotype data available to differentiate between ETP(CD1a^(-),CD8^(-),CD5^(dim),at least one marker of stem cell or myeloid lineage)and non-ETP.From these 74 subjects,12 ETP-ALL cases(16.2%)were identified.The event-free survival(EFS)rate at 66.8 months was 11.1%±10.1% for ETP-ALL and 57.6%±5.6% for non-ETP-ALL(P=0.003).The overall survival rates were 13.3%±11.0% for ETP-ALL and 64.7%±6.3% for non-ETP-ALL(P=0.002).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic leukemia with poor prognosis. | Meilin Ma Xiang Wang Jingyan Tang Huiliang Xue Jing Chen Ci Pan Hua Jiang Shuhong Shen | 2012 | Frontiers of Medicine2012，6，4： | 2 |
| 18 | Significant loss of soil inorganic carbon at the continental scale显示文摘Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and CO_(2) release.However,to date,few studies have addressed these processes.Here,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC)stocks in China.We observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m^(-2)yr^(-1))from the 1980s to the 2010s.Total SIC stocks have decreased by∼8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr^(-1))and in cropland(0.016 Pg C yr^(-1))account for∼17.6%-24.0%of the terrestrial C sink and 57.1%of the soil organic carbon sink in cropland,respectively.Nitrogen deposition and climate change have profound influences on SIC cycling.We estimate that∼19.12%-19.47%of SIC stocks will be further lost by 2100.The consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss. | Xiao-Dong Song Fei Yang Hua-Yong Wu Jing Zhang De-Cheng Li Feng Liu Yu-Guo Zhao Jin-Ling Yang Bing Ju Chong-Fa Cai Biao Huang Huai-Yu Long Ying Lu Yue-Yu Sui Qiu-Bing Wang Ke-Ning Wu Feng-Rong Zhang Ming-Kui Zhang Zhou Shi Wan-Zhu Ma Gang Xin Zhi-Ping Qi Qing-Rui Chang En Ci Da-Gang Yuan Yang-Zhu Zhang Jun-Ping Bai Jia-Ying Chen Jie Chen Yin-Jun Chen Yun-Zhong Dong Chun-Lan Han Ling Li Li-Ming Liu Jian-Jun Pan Fu-Peng Song Fu-Jun Sun Deng-Feng Wang Tian-Wei Wang Xiang-Hua Wei Hong-Qi Wu Xia Zhao Qing Zhou Gan-Lin Zhang | 2022 | National Science Review2022，9，2： | 2 |
| 19 | Establishment and Application of Early Risk Stratification Method for Acute Abdominal Pain in Adults显示文摘 | Yu Wang Hong Zhao Zhen Zhou Ci Tian Hong-Li Xiao Bao-En Wang | 2017 | Chinese Medical Journal2017，，5： | 2 |
| 20 | Sustained release of exosomes loaded into polydopamine-modified chitin conduits promotes peripheral nerve regeneration in rats显示文摘Exosomes derived from mesenchymal stem cells are of therapeutic interest because of their important role in intracellular communication and biological regulation.On the basis of previously studied nerve conduits,we designed a polydopamine-modified chitin conduit loaded with mesenchymal stem cell-derived exosomes that release the exosomes in a sustained and stable manner.In vitro experiments revealed that rat mesenchymal stem cell-derived exosomes enhanced Schwann cell proliferation and secretion of neurotrophic and growth factors,increased the expression of Jun and Sox2 genes,decreased the expression of Mbp and Krox20 genes in Schwann cells,and reprogrammed Schwann cells to a repair phenotype.Furthermore,mesenchymal stem cell-derived exosomes promoted neurite growth of dorsal root ganglia.The polydopamine-modified chitin conduits loaded with mesenchymal stem cell-derived exosomes were used to bridge 2 mm rat sciatic nerve defects.Sustained release of exosomes greatly accelerated nerve healing and improved nerve function.These findings confirm that sustained release of mesenchymal stem cell-derived exosomes loaded into polydopamine-modified chitin conduits promotes the functional recovery of injured peripheral nerves. | Ci Li Song-Yang Liu Meng Zhang Wei Pi Bo Wang Qi-Cheng Li Chang-Feng Lu Pei-Xun Zhang | 2022 | Neural Regeneration Research2022，17，9： | 2 |
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