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| 1 | Characterization of the receptor-binding domain(RBD)of 2019 novel coronavirus:implication for development of RBD protein as a viral attachment inhibitor and vaccine显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Wanbo Tai Lei He Xiujuan Zhang Jing Pu Denis Voronin Shibo Jiang Yusen Zhou Lanying Du | 2020 | Cellular & Molecular Immunology2020，17，6： | 35 |
| 2 | Unmanned air vehicle flow separation control using dielectric barrier discharge plasma at high wind speed显示文摘The present paper described an experimental investigation of separation control of an Unmanned Aerial Vehicle(UAV)at high wind speeds.The plasma actuator was based on Dielectric Barrier Discharge(DBD)and operated in a steady manner.The flow over a wing of UAV was performed with smoke flow visualization in theΦ0.75 m low speed wind tunnel to reveal the flow structure over the wing so that the locations of plasma actuators could be optimized.A full model of the UAV was experimentally investigated in theΦ3.2 m low speed wind tunnel using a six-component internal strain gauge balance.The effects of the key parameters,including the locations of the plasma actuators,the applied voltage amplitude and the operating frequency,were obtained.The whole test model was made of aluminium and acted as a cathode of the actuator.The results showed that the plasma acting on the surface of UAV could obviously suppress the boundary layer separation and reduce the model vibration at the high wind speeds.It was found that the maximum lift coefficient of the UAV was increased by 2.5%and the lift/drag ratio was increased by about 80%at the wind speed of 100 m/s.The control mechanism of the plasma actuator at the test configuration was also analyzed. | ZHANG Xin HUANG Yong WANG WanBo WANG XunNian LI HuaXing | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 8 |
| 3 | Leading-edge flow separation control over an airfoil using a symmetrical dielectric barrier discharge plasma actuator显示文摘In order to promote an in-depth understanding of the mechanism of leading-edge flow separation control over an airfoil using a symmetrical Dielectric Barrier Discharge(DBD) plasma actuator excited by a steady-mode excitation, an experimental investigation of an SC(2)-0714 supercritical airfoil with a symmetrical DBD plasma actuator was performed in a closed chamber and a low-speed wind tunnel. The plasma actuator was mounted at the leading edge of the airfoil.Time-resolved Particle Image Velocimetry(PIV) results of the near-wall region in quiescent air suggested that the symmetrical DBD plasma actuator could induce some coherent structures in the separated shear layer, and these structures were linked to a dominant frequency of f0= 39 Hz when the peak-to-peak voltage of the plasma actuator was 9.8 kV. In addition, an analysis of flow structures without and with plasma actuation around the upper side of the airfoil at an angle of attack of18° for a wind speed of 3 m/s(Reynolds number Re = 20000) indicated that the dynamic process of leading-edge flow separation control over an airfoil could be divided into three stages. Initially, this plasma actuator could reinforce the shedding vortices in the separated shear layer. Then, these vortical structures could deflect the separated flow towards the wall by promoting the mixing between the outside flow with a high kinetic energy and the flow near the surface. After that, the plasma actuator induced a series of rolling vortices in the vicinity of the suction side of the airfoil, and these vortical structures could transfer momentum from the leading edge of the airfoil to the separated region, resulting in a reattachment of the separated flow around the airfoil. | Xin ZHANG Huaxing LI Yong HUANG Kun TANG Wanbo WANG | 2019 | Chinese Journal of Aeronautics2019，32，5： | 7 |
| 4 | Turbulent boundary layer separation control using plasma actuator at Reynolds number 2000000显示文摘试验性的调查被进行在高级雷纳兹数字在狂暴的边界层分离控制上评估对称的血浆致动器的效果。与血浆致动器的传统的控制方法相比,整个测试模型用铝做的并且充当了对称的血浆致动器的一个盖住的电极。包围空气上的血浆致动器效果的试验性的学习,一个正规零压力的坡度狂暴的边界,在 0.75 m 用粒子图象 velocimetry (PIV ) 和激光 Doppler velocimetry (LDV ) 被执行 ? 湯琠敨椠灭捡 ? 景琠敨栠杩敨瑳瘠牯整 ? 湡 ? 敮 'U 牯 ? 潶瑲硥?? | Zhang Xin Huang Yong Wang Xunnian Wang Wanbo Tang Kun Li Huaxing | 2016 | Chinese Journal of Aeronautics2016，29，5： | 7 |
| 5 | Comparison of Modified Mohr-Coulomb Model and Bai-Wierzbicki Model for Constructing 3D Ductile Fracture Envelope of AA6063显示文摘Ductile fracture of metal often occurs in the plastic forming process of parts.The establishment of ductile fracture criterion can effectively guide the selection of process parameters and avoid ductile fracture of parts during machining.The 3D ductile fracture envelope of AA6063-T6 was developed to predict and prevent its fracture.Smooth round bar tension tests were performed to characterize the flow stress,and a series of experiments were conducted to characterize the ductile fracture firstly,such as notched round bar tension tests,compression tests and torsion tests.These tests cover a wide range of stress triaxiality(ST)and Lode parameter(LP)to calibrate the ductile fracture criterion.Plasticity modeling was performed,and the predicted results were compared with corresponding experimental data to verify the plasticity model after these experiments.Then the relationship between ductile fracture strain and ST with LP was constructed using the modified Mohr-Coulomb(MMC)model and Bai-Wierzbicki(BW)model to develop the 3D ductile fracture envelope.Finally,two ductile damage models were proposed based on the 3D fracture envelope of AA6063.Through the comparison of the two models,it was found that BW model had better fitting effect,and the sum of squares of residual error of BW model was 0.9901.The two models had relatively large errors in predicting the fracture strain of SRB tensile test and torsion test,but both of the predicting error of both two models were within the acceptable range of 15%.In the process of finite element simulation,the evolution process of ductile fracture can be well simulated by the two models.However,BW model can predict the location of fracture more accurately than MMC model. | Jianye Gao Tao He Yuanming Huo Miao Song Tingting Yao Wanbo Yang | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 6 |
| 6 | A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)highlights the need to develop effective and safe vaccines.Similar to SARS-CoV,SARS-CoV-2 recognizes angiotensin-converting enzyme 2(ACE2)as receptor for host cell entry.1,2 SARS-CoV-2 spike(S)protein consists of S1,including receptor-binding domain(RBD),and S2 subunits.3,4 We previously demonstrated that RBDs of SARS-CoV and MERS-CoV serve as important targets for the development of effective vaccines. | Wanbo Tai Xiujuan Zhang Aleksandra Drelich Juan Shi Jason CHsu Larry Luchsinger Christopher D.Hillyer Chien-Te KTseng Shibo Jiang Lanying Du | 2020 | Cell Research2020，30，10： | 5 |
| 7 | Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs显示文摘The limited knowledge of genomic noncoding and regulatory regions has restricted our ability to decipher the genetic mechanisms underlying complex traits in pigs. In this study, we characterized the spatiotemporal landscape of putative enhancers and promoters and their target genes by combining H3K27ac-targeted Ch IP-Seq and RNA-Seq in fetal(prenatal days 74–75) and adult(postnatal days 132–150) tissues(brain, liver, heart, muscle and small intestine) sampled from Asian aboriginal Bama Xiang and European highly selected Large White pigs of both sexes. We identified 101,290 H3K27ac peaks, marking 18,521promoters and 82,769 enhancers, including peaks that were active across all tissues and developmental stages(which could indicate safe harbor locus for exogenous gene insertion) and tissue-and developmental stage-specific peaks(which regulate gene pathways matching tissue-and developmental stage-specific physiological functions). We found that H3K27ac and DNA methylation in the promoter region of the XIST gene may be involved in X chromosome inactivation and demonstrated the utility of the present resource for revealing the regulatory patterns of known causal genes and prioritizing candidate causal variants for complex traits in pigs. In addition, we identified an average of 1,124 super-enhancers per sample and found that they were more likely to show tissue-specific activity than ordinary peaks. We have developed a web browser to improve the accessibility of the results(http://gffzzc15bd3fb09e34ed2hb0669kcwnxb065uq.ffgz.tsg.suse.edu.cn/pencode/?genome=sus Scr11). | Yaling Zhu Zhimin Zhou Tao Huang Zhen Zhang Wanbo Li Ziqi Ling Tao Jiang Jiawen Yang Siyu Yang Yanyuan Xiao Carole Charlier Michel Georges Bin Yang Lusheng Huang | 2022 | Science China(Life Sciences)2022，65，8： | 5 |
| 8 | Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses显示文摘Dear Editor,The 2002–2003 global pandemic caused by severe acute respiratory syndrome coronavirus(SARS-CoV)infected around 8,000 people with 10%mortality(http://gffzz36b398b81f8a4a4chb0669kcwnxb065uq.ffgz.tsg.suse.edu.cn/csr/sars/en/).The virus has a positivestranded RNA genome that encodes a large polyprotein(1a and 1ab),four structural proteins,including spike(S), | Lei-Ping Zeng Xing-Yi Ge Cheng Peng Wanbo Tai Shibo Jiang Lanying Du Zheng-Li Shi | 2017 | Science China(Life Sciences)2017，60，12： | 4 |
| 9 | New discoveries from the classic Quaternary mammalian fossil area of Yanjinggou,Chongqing,and their chronological explanations显示文摘Yanjinggou in Wanzhou District of Chongqing is one of the earliest reported and most famous Quaternary mammalian fossil areas in China.The fauna from this area used to be taken as a benchmark for the biochronological comparison of Quaternary paleontology of South China,but the chronology of this fauna has many controversies for the lack of exact locational and stratigraphical records.The present article,on the basis of recent investigations and discoveries,discusses and explains the distribution and biochronology of the mammalian faunas in the Yanjinggou area.The newly discovered Dayakou fissure fauna,including Rhizomys troglodytes,Homotherium sp.,Panthera pardus,Stegodon orientalis,Dicerorhinus sumatrensis,Hesperotherium sinense,Sus sp.,Cervavitus fenqii,Cervus sp.and Muntiacus sp.,is correlated to the middle Early Pleistocene.The presence of Early Pleistocene mammalian fauna in the Yanjinggou area is therefore confirmed.The'Wanhsien fauna'or'Yenchingkou(=Yanjinggou)fauna'as a Mid-Late Pleistocene biostratigraphical datum should be abandoned.The Dayakou fauna and the Upper Cave fauna of Pingba,both in the Yanjinggou area,are correlated to the middle Early Pleistocene and the early Middle Pleistocene in age,respectively. | CHEN ShaoKun PANG LiBo HE CunDing WEI GuangBiao HUANG WanBo YUE ZongYing ZHANG XiaoHu ZHANG Hua QIN Li | 2013 | Chinese Science Bulletin2013，58，31： | 4 |
| 10 | Design,Manufacture and Maintenance of Pressure Equipment Based on Accidents Survey显示文摘Most of the important units of pressure equipment have been manufactured successfully in China related to the national key construction projects,such as 10 million tons/year oil refinery,million tons/year ethylene,large coal chemical,etc.However,some of them failed to operate shortly after their putting into service.Some suffered severe damage even during the previous period of manufacture and installation.In this paper,cases of accident survey and failure analysis are given for some typical pressure vessels.It is found that many accidents are related to insufficient consideration of the design and manufacture of the equipment.These accidents occur fundamentally because of the Chinese design standards & codes for pressure equipment without risk or life concepts and the support from a database for potential risk existing in their dynamic service.Most designers and manufacturers are unable to make correct design,materials selection and manufacturing process all due to a lack of engineering experience.In order to avoid the repetition of the accidents and improve the safety,reliability and economy of pressure equipment,a platform is suggested for design,manufacture and maintenance of pressure equipment in China based on accidents survey.In other words,some effective precautionary measures are taken at the design and manufacture stage,and the design methodology has to be based on service life requirement and desirable risk level.At the service stage some reasonable inspection/monitoring approaches should be utilized to control risks and ensure the equipment operating safely until its desired lifespan.Finally,the basic scheme and some key technologies are briefly given for the platform construction.The concept of risk and life based design,manufacture and maintenance proposed herein has important significance for improving and perfecting the codes and standards for design,manufacture and maintenance of Chinese pressure-bearing equipment,enhancing the life and reliability of Chinese pressure-bearing equipment and promoting the development of in-service maintenance technology that combines safety and economy. | CHEN Xuedong AI Zhibin FAN Zhichao WANG Bing DOU Wanbo YANG Tiecheng GUAN Weihe | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 3 |
| 11 | The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease显示文摘 | Wanbo JE Lonser RR Glenn GM | 2003 | J Neurosurgery2003，17，： | 1 |
| 12 | A simple Bayesian estimation of the Gumbel distribution显示文摘 | LU Wanbo | 2008 | Proceeding of the 2008 IEEE IEEM2008，，： | 1 |
| 13 | A simple Bayesian estimation of the Log-Logistic distribution显示文摘 | LU Wanbo KE Rui | 2013 | Internation- al Conference on Guality Reliability Risk Maintenance and Safety Engineering2013，2013，： | 1 |
| 14 | Paleolithic culture of Longgupo and its creators显示文摘 | Guangbiao Wei Wanbo Huang Shaokun Chen Cunding He Libo Pang Yan Wu | 2014 | Quaternary International2014，，： | 1 |
| 15 | A contextual usage con- trol model显示文摘 | Luo Xiaofeng Li Lin Luo Wanbo | 2014 | Technical Gazette2014，21，1： | 1 |
| 16 | OD Matrix Infer- ence for Urban Public Transportation Trip Based on GPS and IC Card Data显示文摘 | Yang Wanbo Wang Hao Ye Xiaofei Xu Ch- uangchuang Jiang Dongxue | 2015 | Journal of Chongqing Jiaotong University(Natural Sci- ence)2015，34，3： | 1 |
| 17 | A survey of catadioptric omnidirectional camera calibration显示文摘 | Zhang Yan Zhao Lina Hu Wanbo | 2013 | Information Technology and Computer Science2013，3，： | 1 |
| 18 | Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant显示文摘Dear Editor,The COVID-19 pandemic has had a devastating effect on global health,resulting in over 6.2 million deaths worldwide.Continuous emergence of adaptive mutations of SARS-CoV-2 alters its pathogenicity and transmissibility,and renders its resistance to current vaccines and antiviral drugs.1 A new variant named Omicron discovered initially in South Africa has recently been proposed as a variant of concern(VOC)by the World Health Organization,because of its high transmissibility and resistance to current vaccines and therapeutic antibodies.2 Therefore,development of vaccines against prevalent variants including Omicron is urgently needed for COVID-19 prevention. | Wanbo Tai Benjie Chai Shengyong Feng Xinyu Zhuang Jun Ma Mujia Pang Lin Pan Zi Yang Mingyao Tian Gong Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 19 | Interval censored sampling plans for the gamma lifetime model 显示文摘 | Wanbo Lua and Tzong-Ru Tsaib | 2009 | European Journal of Operational Research2009，192，1： | 1 |
| 20 | Dynamic behaviors of the periodic Lotka-Volterra competing system with impulsive perturbations显示文摘 | Bing Liu Zhidong Teng Wanbo Liu | 2007 | Chaos Solitons and Fractals2007，31，2： | 1 |
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