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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘 | Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno | 2013 | Gut2013，，12： | 2 |
| 3 | Childhood Allergic Rhinitis Predicts Asthma Incidence and Persistence to Middle Age: A Longitudinal Study显示文摘 | Burgess J A Walters E H Byrnes G B | 2007 | J Allergy Clin Immunol2007，120，4： | 1 |
| 4 | A role for mammalian Ubc6 homo- logues in ER-associated protein degradation 显示文摘 | LENK U YU H WALTER J | 2002 | J Cell Sci2002，115，： | 1 |
| 5 | Cellular composition and viability of demi-and quarter-embryos made from bisected bovine morulae and blastocysts显示文摘 | Gyu-Jin R Walter H J | 1998 | Theriogenology1998，50，： | 1 |
| 6 | Characterization of reuterocyclin produced by Lactobacillus reuteri LTH2584 显示文摘 | G?nzle M G H?ltzel A Walter J | 2000 | Applied and Environmental Microbiology2000，66，： | 1 |
| 7 | Object representation and recognition in shape spaces 显示文摘 | ZHANG J ZHANG X KRIM H WALTER G G | 2003 | Pattern recognition2003，36，： | 1 |
| 8 | Analysis of an Orthotropic Deck Stiffened with a Cement-based Overlay 显示文摘 | WALTER R OLESEN J F STANG H | 2007 | Journal of Bridge Engineering2007，12，3： | 1 |
| 9 | Approximate Expressions for the Elastic Con- stants of Cord Rubber Laminates 显示文摘 | Walter J D Patel H P | 1979 | Rubber Chemistry Technolo- gy1979，52，4： | 1 |
| 10 | p38 mitogen-activated protein kinase downregulates endothelial progenitor cells显示文摘 | Seeger F H Haendeler J Walter D H | 2005 | Circulation2005，111，19： | 1 |
| 11 | Coaxial stacking of helixes enhances binding of oligoribonucleotides and improves predictions of RNA folding显示文摘 | Walter A E Turner D H Kim J | 1994 | Proceedings of the National Academy of Sci-ences1994，91，20： | 1 |
| 12 | Bean ribonuclc- ase-like pathogenesis-related protein genes (YprlO) display complex patterns of developmental, dark-induced and exoge- nous-stimulus-dependent expression显示文摘 | WALTER M H LIU J W WUNN J | 1996 | European Journal of Biochemistry1996，239，2： | 1 |
| 13 | Field effect electroluminescence in silicon nanocrystals显示文摘 | WALTERS R J BOURIANOFF G I ATWATER H A | 2005 | Nat Mater2005，4，2： | 1 |
| 14 | The Effect Negative Word of Mouth Behavior and Repatronage Intention 显示文摘 | Blodgett G J Granbois D H Walters of Perceived Justice on Complaints' R G | 1993 | Retailing1993，69，12： | 1 |
| 15 | Distinct sites of insulin-like growth factor (IGF)-Ⅱ expression and localization in lesioned rat brain:possible roles of IGF binding proteins (IGFBPs) in the mediation of IGF-Ⅱ activity显示文摘 | Walter H J Berry M Hill DJ Cwyfan-Hughes S Holly JM Logan A | 1999 | Endocrinology1999，140，1： | 1 |
| 16 | Discovery of a mu- tant-selective covalent inhibitor of EGFR that overcomes T790M- mediated resistance in NSCLC显示文摘 | Walter A O Sjin R T Haringsma H J | 2013 | Cancer Discov2013，3，12： | 1 |
| 17 | Evidence for a Second Crystal Form of Polypropylene显示文摘 | Keith H D Padden F J Walter N M | 1959 | J Appl Phys1959，30，10： | 1 |
| 18 | Preclinical evaluation of new and highly potent analogues of octreotide for predictive imaging and targeted radiotherapy显示文摘 | INJ M CHEN J H WALTER M A | 2005 | Clin Can Res2005，11，3： | 1 |
| 19 | Cellular composition and bility of' demi- and quarrel-embryos made from Insected bovine morulae and blas- toeysts显示文摘 | Gyu-Jin Rho Walter H J | 1998 | Theriogenlogy1998，50，： | 1 |
| 20 | Gene therapy for the hemophiliac 显示文摘 | Walter J H K A | 1997 | Adv Vet Med1997，12，23： | 1 |
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