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| 1 | 大鼠戊四唑点燃模型的建立显示文摘给大鼠戊四唑(PTZ)亚惊厥剂量(30 mg/kg,ip),每日一次,连续给药28 d.建立了戊四唑化学点燃模型。采用七点评分法观察行为惊厥和脑电图变化。凡连续5次获二级或二级以上惊厥者,被认为完全点燃。结果表明,28 d龄大鼠总点燃率为74%,全身性肌阵挛为其典型症状。行为惊厥与脑异常放电同步。凡有行为惊厥者皆伴有恼电图棘波或棘慢波放电。停止处理4周后。点燃大鼠仍保持其点燃状态。提示本文所用PTZ剂量合理,方法可靠且简单易行。 | 王丽 J Ono PD Walson | 1993 | 药学学报1993，28，7： | 67 |
| 2 | Lack of correlation between Treg quantification assays in inflammatory bowel disease patients显示文摘AIM:To compare the number of regulatory T-cells( Tregs) measured by flow cytometry with those obtained using a real-time quantitative PCR(q PCR) method in patients suffering from inflammatory bowel disease(IBD).METHODS:Tregs percentages obtained by both flow cytometry and q PCR methods in 35 adult IBD patients,18 out of them with Crohn′s disease(CD)and 17 with ulcerative colitis(UC)were compared to each other as well as to scores on two IBD activity questionnaires using the Harvey Bradshaw Index(HBI)for CD patients and the Simple Colitis Clinical Activity Index(SCCAI)for UC patients.The Treg percentages by flow cytometry were defined as CD4+CD25highCD127lowFOXP3+cells in peripheral blood mononuclear cells,whereas the Treg percentages by q PCR method were determined as FOXP3 promoter demethylation in genomic DNA.RESULTS:We found an average of 1.56%±0.78%Tregs by using flow cytometry,compared to 1.07%±0.53%Tregs by using q PCR in adult IBD patients.There were no significant correlations between either the percentages of Tregs measured by flow cytometry or q PCR and the HBI or SCCAI questionnaire scores in CD or UC patients,respectively.In addition,there was no correlation between Treg percentages measured by q PCR and those measured by flow cytometry(r=-0.06,P=0.73;Spearman Rho).These data suggest that,either Treg-related immune function or the clinical scores in these IBD patients did not accurately reflect actual disease activity.Until the cause(s)for these differences are more clearly defined,the resultssuggest caution in interpreting studies of Tregs in various inflammatory disorders.CONCLUSION:The two methods did not produce equivalent measures of the percentage of total Tregs in the IBD patients studied which is consistent with the conclusion that Tregs subtypes are not equally detected by these two assays. | Gunnar Brandhorst Darinka Todorova Petrova Sebastian Weigand Christoph Eberle Nicolas von Ahsen Jessica Schmitz Frank Christian Schultze Dirk Raddatz Michael Karaus Michael Oellerich Philip D Walson | 2015 | World Journal of Gastroenterology2015，21，11： | 2 |
| 3 | Analomie of amygdaloid and hippocampal volume measuremenl by magnelie resonace imagihg 显示文摘 | Walson T Andermann F Gloor P | 1992 | Neurology1992，42，9： | 1 |
| 4 | Longitidinal study of Levodopa/carbidopa for children amblyopia显示文摘 | Leguire LE Walson PD Rogers GL | 1993 | J Pediatr Ophthalmol Straismus1993，30，： | 1 |
| 5 | Clonazepam and 7-aminoclonazepam in human plasma显示文摘 | Edge JH Walson PD Rane A | 1991 | Ther Drug Moni1991，13，4： | 1 |
| 6 | Levodopa/carbidopa treatment for amblyopia in older children显示文摘 | Leguire LE Walson PD Rogers GL | 1995 | J Pediatr Ophthalmol Strabismus1995，32，： | 1 |
| 7 | Pharmacokinetic comparison of acetaminophen elixir versus suppositories in vaccinatedinfants (aged 3 to 36 months) : a single-dose, open- label, randomized, parallel-group design 显示文摘 | Walson PD Halvorsen M Edge J | 2013 | Clin Ther2013，35，2： | 1 |
| 8 | Gasless laparoscopy may reduce the risk of port site metastases following laparascopic tumor surgery显示文摘 | Walson D I Mathew G Ellis T | 1997 | Arch Surg1997，132，2： | 1 |
| 9 | Electrocorticographical observation of seizures induced by pentylenetetrazol injection in rats显示文摘 | Ono J Vieth RF Walson PD | 1990 | Functional Neurol1990，5，： | 1 |
| 10 | Comparison of muhidose ibuprofen and acetaminophen therapy in febrile children 显示文摘 | WALSON P D GALLETTA G CHOMILO F | 1992 | American Journal of Diseases of Children1992，146，5： | 1 |
| 11 | Electrocorticographical observation of seizures induced by pentylenetetrazol(PTZ) injection in rats 显示文摘 | Ono J Vieth RF Walson PD | 1990 | Funct Neurol1990，5，4： | 1 |
| 12 | Cholecystectomy and gas- tro-esophageal reflux显示文摘 | Walson T N Jazrawi S Byrne P J et aI | 1991 | Br J Surg1991，78，： | 1 |
| 13 | Stat6 is necessary and sufficient for IL-4, s role in Th2 differentiation and cell expansion显示文摘 | Zhu J Guo L Walson CJ | 2001 | J Immunol2001，166，12： | 1 |
| 14 | Longitudinal study of levodopa/carbidopa for childhood amblyopia显示文摘 | LEGUIRE L E WALSON P D ROGERS G L | 1993 | J Pediatr Ophthalmol Strabismus1993，30，6： | 1 |
| 15 | Conservation policy people conflicts: a case study from Nanda Devi Biosphere Reserve 显示文摘 | Walson J | 2001 | Forest Policy and E- conomics2001，2，34： | 1 |
| 16 | Longitudinal study of levodopa/carbidopa for childhood amblyopia 显示文摘 | Leguire LE Walson PD Rogers GL | 1993 | J Pediatr Ophthalmol Strabismus1993，30，： | 1 |
| 17 | Longitudinal study of levodopa/carbidopa for childhood amblyopia 显示文摘 | Leguire LE Walson PD Rogers GL | 1993 | J Pediatr Ophthalmol Styabismus1993，30，6： | 1 |
| 18 | Population pharmacokinetics of felbamate in children显示文摘 | Walson PD Cox S Dusci LJ | 1997 | Ther Drug Monit1997，19，： | 1 |
| 19 | Analysis of high risk elements related to upper gastrointestinal bleeding following sereve craniocerebral injury显示文摘 | Mericle RO Walson LR | 1988 | Neurosurgery1988，68，： | 1 |
| 20 | Stigma in Ethiopia: association with depressive symptoms in people with H1V 显示文摘 | Endeshaw M Walson J Rawlins S | 2014 | AIDS Care2014，26，8： | 1 |
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