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| 1 | SOX2,a persistent marker for multipotential neural stem cells derived from embryonic stem cells,the embryo or the adult显示文摘 | Ellis P Fagan B M Magness S T | | 0，，24： | 2 |
| 2 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 3 | Contrasting seed storage behaviour among different species of Meliaceae 显示文摘 | Hong T D Ellis R H | 1998 | Seed science and technology1998，26，1： | 1 |
| 4 | Formation of micronuclei in erythrocytes of the fathead minnow (Pimcphales promelas) after acute treatment with mitomycin C or cyclophosphamide 显示文摘 | WINTER M J ELLIS L C HUTCHINSON T H | 2007 | Mut Res2007，629，2： | 1 |
| 5 | Survival of Dry and Ultra-Dry Seeds of Carrot, Groundnut, Lettuce, Oil seed Rape and Onion During Five Years Hermetic Storage at Two Temperatures 显示文摘 | ELLIS R H HONG T D ASTLEY D | 1996 | Seed Science and Technology1996，24，1： | 1 |
| 6 | A comparison of the low moisture content limit to the logarithmic relation between seed moisture content and longevity in twelve species显示文摘 | Ellis R H Hong T D Roberts E H | 1989 | Annals of Botany1989，，63： | 1 |
| 7 | Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase显示文摘 | Ellis D R Sors T G Brunk D G | 2004 | BMC Plant Biol2004，4，： | 1 |
| 8 | Estimation of market value of Central African tea by theaflavin analysis 显示文摘 | HILTON P J ELLIS R T | 1972 | J Sci Food Agric1972，23，： | 1 |
| 9 | Femoral neck/ shaft fracture显示文摘 | TORNETTA P Ellis T SWlONTKOW SKIM | 2003 | J Orthop Trauma2003，17，2： | 1 |
| 10 | Structure function and evolution of plant disease resistance genes 显示文摘 | Ellis J Dodds P Pryor T | 2000 | Curr Opin Plant Biology2000，3，： | 1 |
| 11 | DNA assembly for synthetic biology: from parts to pathways and beyond 显示文摘 | Ellis T Adie T Baldwin G S | 2011 | Integrative Biology2011，3，2： | 1 |
| 12 | Association of genetic variation in the natriureAtrial natriuretic peptide in patients with cardiovascular outcomes显示文摘 | Ellis K L Newton-Cheh C Wang T J | 2011 | J Mol Ce(I Cardiol2011，50，4： | 1 |
| 13 | The collapse of cavitation bubbles and the pressures thereby produced against solid boundaries 显示文摘 | BENJAMIN T B ELLIS A T | 1966 | Philosophical Transactions of the Royal Society A: Mathematical Physical and Engineering Science1966，260，1110： | 1 |
| 14 | The collapse of cavitation bubbles and the pressures thereby produced against solid boundaries 显示文摘 | Benjamin T B Ellis A T | 1966 | Philosophical Transactions of the Royal Society of London1966，260，： | 1 |
| 15 | The relationshipamong diet,alimentary tract morphology, and life history forfive species of rodents from the central Argentine pampa显示文摘 | ELLIS B A MILLS J N KENNEDY E J T | 1994 | Acta Theriol1994，39，： | 1 |
| 16 | Angiogenesis in poorly differentiated medullary carcinoma of stomach显示文摘 | Ellis LM Ohta T | 1998 | Surg Today1998，28，8： | 1 |
| 17 | Reemerging H5NI influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks显示文摘 | Sturm-Ramirez K M Ellis T Bousfield B | 2004 | Journal of Virology2004，78，9： | 1 |
| 18 | Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus 显示文摘 | Payne C J Ellis T M Plant S L | 1999 | Veterinary Microbiology1999，68，： | 1 |
| 19 | On-line molecular weight distribution estimation and control in batch polymerization显示文摘 | Ellis M F Taylor T W Jensen K F | 1994 | AIChE Journal1994，40，3： | 1 |
| 20 | A copia-like element in Pisum demonstrates the uses of dispersed repeated sequences in genetic analysis显示文摘 | Lee D Ellis T H N Tumer L | 1990 | Plant Mol Biol1990，15，： | 1 |
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