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| 1 | Heparin improves organ microcirculatory disturbances in caerulein-induced acute pancreatitis in rats显示文摘AIM: Microcirculatory disturbances are important early pathophysiological events in various organs during acute pancreatitis. The aim of the study was to evaluate changes in rnicroperfusion of the pancreas, liver, kidney, stomach,colon, skeletal muscle, and to investigate the influence of heparin on the organ rnicrocirculation in caerulein-induced experimental acute pancreatitis.METHODS: Acute pancreatitis was induced by 4 intraperitoneal injections of caerulein (Cn) (15 μg/kg). The organ microcirculation was measured by laser Doppler flowrnetry. Serum interleukin 6 and hernatocrit levels were analysed.RESULTS: Acute pancreatitis resulted in a significant drop of microperfusion in all examined organs. Heparin administration (2×2.5 mg/kg) improved the rnicrocirculation in pancreas (36.9±4% vs75.9±10%), liver (56.6±6% vs 75.2±16%), kidney (45.1±6% vs79.3±5%), stomach (65.2±8% vs78.1±19%), colon (69.8±6% vs 102.5±19%),and skeletal muscle (59.2±6% vs 77.9±13%). Heparin treatment lowered IL-6 (359.0±66 U/mL vs 288.5±58 U/mL) and hematocrit level (53±4% vs 46±3%).CONCLUSION: Hepadn administration has a positive influence on organ microcirculatory disturbances accompanying experimental Cn-induced acute pancreatitis. | Marek Dobosz Lucjanna Mionskowska Stanislaw Ha■ Sebastian Dobrowolski Dariusz Dymecki Zdzislaw Wajda | 2004 | World Journal of Gastroenterology2004，10，17： | 34 |
| 2 | Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats显示文摘AIM: To investigate the influence of neutrophil adhesion molecule blockade with monoclonal antibody (MoAb CD11b) and E. coli lipopolysaccharide (LPS)administration on experimental acute pancreatitis (AP).METHODS: AP was induced by four ip injections of cerulein (Cn) at 1-h intervals. MoAb CD 11b and LPS were administered at the beginning of the experiment.RESULTS: The neutrophil count and chemiluminescence were diminished at the beginning of AP. The oxidative stress parameters were found within the pancreatic gland. MoAb CD 11b used for AP resulted in a significant reduction of pancreatic infiltration and pancreatitis oxidative stress parameters. Serum interleukin-6 (IL-6)was not detected in AP animals, whereas high serum IL-6 concentration was noted only in animals receiving LPS.CONCLUSION: Neutrophils are involved in pancreatic damage in the early stage of AP. Neutrophil infiltration reduction protects the pancreatic gland from destruction during AP. LPS does not change the early course of Cn pancreatitis in rats. | Stanisiaw Ha Marek Dobosz Jan J Kaczor Robert Rzepko Ewa Aleksandrowicz-Wrona Zdzislaw Wajda Zbigniew ledzi■ski Jacek Krajewski | 2005 | World Journal of Gastroenterology2005，11，41： | 7 |
| 3 | 神经酰胺脂质体——含角质层脂质膜的脂质体显示文摘角质层的渗透屏障大多是由饱和脂质如神经酰胺、胆固醇和游离脂肪酸组成。它是物质交换的有效阻隔并防止皮肤干燥。神经酰胺脂质体(Cerasomes)是一种脂质体,它的膜是由最重要的角质层脂质组成的。神经酰胺脂质体作为类皮肤膜的来源,它能加快受损屏障层的再生、降低皮肤刺激,并且它还提供了将角质层脂质应用于化妆品中简单而有效的途径。 | Rudi Wajda 孙莉明 | 2005 | 香料香精化妆品2005，，2： | 5 |
| 4 | The Clustering of Other Chronic Inflammatory Diseases in Inflammatory Bowel Disease: A Population-Based Study显示文摘 | Charles N. Bernstein Andre Wajda James F. Blanchard | 2005 | Gastroenterology2005，，3： | 2 |
| 5 | The efficacy of lactic acid bacteria Pediococcus acidilactici, lactose and formic acid as dietary supplements for turkeys显示文摘 | Wajda S,Smiecinska K Jankowski J | 2010 | Pol J Vet Sci,2010，13，1： | 1 |
| 6 | Nitric oxide,heparin and pro-caine treatment in experimental ceruleine-induced acute pancreatitisin rats显示文摘 | Dodosz M Wajda Z Hac S | 2013 | Arch Immunol Ther Exp(Warsz)2013，47，3： | 1 |
| 7 | Photosynthetic activities of cadmium-treated tomato plants显示文摘 | Baszynski T Wajda L Krol M | 1980 | Physiol Plant1980，48，： | 1 |
| 8 | The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study显示文摘 | BERNSTEIN C N WAJDA A BLANCHARD J F | 2005 | Gastroenterology2005，129，： | 1 |
| 9 | Photosynthetic activities of cadmium - treated tomato plants显示文摘 | Baszynski T Wajda L Krol M | 1980 | Physiol Plant1980，48，： | 1 |
| 10 | Photosynthetic activities of cadmium-treated tomato显示文摘 | BASZYNSKI T WAJDA L KROL M | 1980 | Physiol Plant1980，48，： | 1 |
| 11 | Bull calves or steers as slaughter animals显示文摘 | Wajda S Wlodawiec P | 2000 | Gospoderka Miasma2000，54，4： | 1 |
| 12 | Photosynthetic activities of cadmium treated tomato phants显示文摘 | BASZYNSKI T WAJDA L KROL M | 1980 | Physiology of Plant1980，48，： | 1 |
| 13 | Photosynthetic activities of cadmium-treated tomato plants显示文摘 | Baszynski T Wajda L Wolinska D | 1980 | Physiology of Plant1980，48，： | 1 |
| 14 | Photosynthetic activities of cadmium-treated tomato plants显示文摘 | Baszynski T Wajda L Krol M Wolinska D Krupa Z Tukend- off A | 1980 | Physiologia of Plantarum1980，48，： | 1 |
| 15 | Biological comparison of local anaesthetics显示文摘 | Bulbrin E WAJDA I | 1945 | J Pharmacol Exp Ther1945，85，： | 1 |
| 16 | The incidence of Ar- terial thromboembolic diseases in inflammatory bowel disease: a population-based study显示文摘 | Bernstein CN Wajda A Blanchard JF | 2008 | Clin Gastroenterol Hepatol2008，6，： | 1 |
| 17 | Does nitric oxide protect from microcirculatory disturbances in experimental acute pancreatitis in rats? 显示文摘 | Dobosz M Hac S Wajda Z | 1996 | Int J Microcirc Clin Exp1996，16，5： | 1 |
| 18 | The Clustering of Other Chronic Inflammatory Diseases in Inflammatory Bowel Disease: A Population-Based Study显示文摘 | Charles N. Bernstein Andre Wajda James F. Blanchard | 2005 | Gastroenterology2005，，3： | 1 |
| 19 | Does nitric oxide protects from micro- circulatory disturbances in experimental acute pancreatitis in rats 显示文摘 | DoboszM Hac S Wajda Z | 1996 | Int J Microcirc Clin Exp1996，16，3： | 1 |
| 20 | Does nitrie oxide protect from microircul- atory disturbances显示文摘 | Dobosz M Hac S Wajda Z | 1996 | In experimental Exp1996，16，： | 1 |
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