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190篇 您的检索式：作者名="Wainwright A"

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	题名	作者	年代	出处	被引量
1	IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。	Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright	2018	Cellular & Molecular Immunology2018，15，5：	17
2	Distributed dynamic modeling of interrill overland flow 显示文摘	Parsons A J Wainwright J Abrahams A D	1997	Hydrological Processes1997，11，：	1
3	Clinical evaluation of an cellular allograft dermal matrix in full thickness burns显示文摘	Wainwright DJ Madden M Luterman A	1996	J Bum Care Rehabil1996，17，1：	1
4	Clinical evaluation of an acellular allograft dermalmatrix in full-thick-ness burns显示文摘	Wainwright D Madden M Luterman A	1996	J Burn Care Rehabil1996，17，2：	1
5	Platelets in the syn- ovial fluid of patients with rheumatoid arthritis 显示文摘	Farr M Wainwright A Salmon M	1984	Rheumatol Int1984，4，1：	1
6	Nebulised hypertonic saline solution for acute bronchiolitis in infants显示文摘	Zhang L Mendoza-Sassi R A Wainwright C	2013	Cochrane Database of Systematic Reviews2013，5，3：	1
7	Clinical evaluation of an acellular allograit dermal matrix in full-thickness brnm显示文摘	Wainwright D Madden M Luterman A	1996	J Bum Care Rehabil1996，17，2：	1
8	Comparison of slope estimates from low resolution DEMs: sealing issues and a fractal method for their solution 显示文摘	Zhang X Nick A Wainwright	1999	Earth Surface Processes and Landforms1999，24，：	1
9	Inhibition of plateleta activity by S-nitrosoglutathione during coronary angioplasty显示文摘	LANGFORD E J BROWN A S WAINWRIGHT R J	1994	Lancet1994，344，：	1
10	Particle Velocity and Mass Measurement in Pneumatic Conveyors 显示文摘	Beck M S Drane J Plaskowski A Wainwright N	1968	Powder Technology1968，2，：	1
11	Geographic gossip : Efficient averaging for sensor net-works 显示文摘	DIMAKIS A D G SARWATE A D WAINWRIGHT MJ	2008	IEEE Transactions on Signal Processing2008，56，3：	1
12	Clincical evaluation of an acellular allograft dermal matrix in full-thickness burns显示文摘	Wainwright DJ Madden M Luterman A	1996	J Burn Care Rehabil1996，17，：	1
13	Geo- graphic Gossip: Efficient Averaging for Sensor Networks 显示文摘	Dimakis A D G Sarwate A D and Wainwright M J	2008	IEEE Transactions on Signal Processing2008，56，3：	1
14	Platelets in the synovial fluid of patients with rheumatoid arthritis显示文摘	WAINWRIGHT A SALMON M	1984	Rheumatol Int1984，4，1：	1
15	Mast cell de- granulation a mechanism for the anti-arrhythmic effect of endothelin - 1 显示文摘	Walsh S K Kane K A Wainwright C L	2009	Britishi Journal of Pharmacology2009，157，5：	1
16	The Formation of 1,2-Naphthoquinone in the Vanadia-catalysed Oxidation of Naphthalene显示文摘	Wainwright M S Bridgewater A J Chaplin R P	1986	J Mol Catal1986，38，3：	1
17	Clinical evaluation of an acellular allograft dermal matrix in full-thickness burns显示文摘	Wainwright D J Madden M Luterman A	1996	J Burn Care Rehabil1996，17，2：	1
18	Clinical evaluation of an acellular allograft dermal matrix in full-thickness burns显示文摘	Madden M Luterman A	1996	Burn Care Rehabil1996，17，：	1
19	Network Coding for Distributed Storage Systems显示文摘	DIMAKIS A GODFREY P WAINWRIGHT M	2010	IEEE Transactions on Information Theory2010，56，9：	1
20	Healthy Lifestyle Choices: Could Sense of Coherence Aid Health Promotion?显示文摘	Wainwright N W Surtees P G Welch A A	2007	J Epidemiol Community Health2007，61，10：	1

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