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| 1 | Hepatitis C virus in Pakistan:A systematic review of prevalence,genotypes and risk factors显示文摘In Pakistan more than 10 million people are living with Hepatitis C virus (HCV), with high morbidity and mortality. This article reviews the prevalence, genotypes and factors associated with HCV infection in the Pakistani population. A literature search was performed by using the keywords; HCV prevalence, genotypes and risk factors in a Pakistani population, in Pubmed, PakMediNet and Google scholar. Ninetyone different studies dating from 1994 to May 2009 were included in this study, and weighted mean and standard error of each population group was calculated. Percentage prevalence of HCV was 4.95% ± 0.53% in the general adult population, 1.72% ± 0.24% in the pediatric population and 3.64% ± 0.31% in a young population applying for recruitment, whereas a very high 57% ± 17.7% prevalence was observed in injecting drug users and 48.67% ± 1.75% in a multi-transfused population. Most prevalent genotype of HCV was 3a. HCV prevalence was moderate in the general population but very high in injecting drug users and multi-transfused populations. This data suggests that the major contributing factors towards increased HCV prevalence include unchecked blood transfusions and reuse of injection syringes. Awareness programs are required to decrease the future burden of HCV in the Pakistani population. | Yasir Waheed Talha Shafi Sher Zaman Safi Ishtiaq Qadri | 2009 | World Journal of Gastroenterology2009，15，45： | 12 |
| 2 | Molecular study of HCV detection,genotypes and their routes of transmission in North West Frontier Province,Pakistan显示文摘Objective:To determine hepatitis C virus(HCV) genotypes and explore the associated risk factors in chronic HCY patients.Methods:A total of 116 patients with chronic hepatitis C were subjected to polymerase chain reaction(PCR) based detection out of which 112 chronic HCV patients[53 male(47.32%),59 female(52.68%);mean age(43.76±16.40) years;mean BMI(23.8± 3.9)kg]were enrolled in this study.The frequency of 6 HCV genotypes and associated risk factors were evaluated from five districts of North West Frontier Province(NWFP).Results:Genotype 3was the most prevalent in 73 samples(65.17%) followed by genotype 1 in 24(21.42%) and genotype2 in 13(11.60%) samples.Genotype3 had significantly high prevalence(P=0.0002).The results showed that 48(42.85%) samples were infected with HCV 3a:25(22.32%) with 3b;14(12.50%) with 1a;10(8.92%)with 1b;11(9.82%) with 2a;2(1.78%) with 2b;and 2 were untypable.The distribution of HCV genotypes in Murdan.Charsadda,Peshawar.Sawabi and Nowshehra districts was different.Use of unsterile equipment lor medication,barbers and previous history of hospitalization were the main risk factors for HCV transmission.Conclusions:Cenotype 3a and 3b.1a.1b and 2a are the common genotypes in NWFP.Genotype 4.5.and 6 can not be found in a single sample.The level of awareness about various modes ot transmission of HCV among the population is found to be verv low. | Asher Zaman Safi Yasir Waheed Joharia Sadat Solat-Ul-Islam Sadia Salahuddin Umar Saeed Muhammad Ashraf | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，7： | 5 |
| 3 | 眼血流的变化对青光眼病情进展的影响(英文)显示文摘青光眼是由多种因素引起的神经退行性疾病,眼压过高会损害视神经而导致永久性视力丧失。虽然青光眼的基本病理生理机制尚未确定,但眼组织如视神经,视网膜,脉络膜以及虹膜的血流改变是青光眼发病的重要危险因素。由于不同因素所引发的视神经损害的有限认知,测量方法和治疗方面缺乏,人们对青光眼的理解存在障碍。尽管研究人员在不断地积累证据,力证眼血流的变化在青光眼发病机制中起着重要的作用,但大部分情况下,对于眼血流的变化和青光眼的患病风险之间的关系,他们都持有多样甚至矛盾的结论。本文中,我们回顾了青光眼的不同方面以及眼血流在疾病发展中的影响。 | Sher Zaman Safi Mamoona Noreen Muhammad Imran Yasir Waheed Muhammad Imran Amir Miraj Ul Hussain Shah Nawshad Muhammad | 2017 | 国际眼科杂志2017，17，3： | 3 |
| 4 | Trends in species distribution modelling in context of rare and endemic plants:a systematic review显示文摘Background:Many research papers have utilized Species Distribution Models to estimate a species’current and future geographic distribution and environmental niche.This study aims to(a)understand critical features of SDMs used to model endemic and rare species and(b)to identify possible constraints with the collected data.The present systematic review examined how SDMs are used on endemic and rare plant species to identify optimal practices for future research.Results:The evaluated literature(79 articles)was published between January 2010 and December 2020.The number of papers grew considerably over time.The studies were primarily conducted in Asia(41%),Europe(24%),and Africa(2%).The bulk of the research evaluated(38%)focused on theoretical ecology,climate change impacts(19%),and conservation policy and planning(22%).Most of the papers were published in publications devoted to biodiversity conservation,ecological or multidisciplinary fields.The degree of uncertainty was not disclosed in most studies(81%).Conclusion:This systematic review provides a broad overview of the emerging trends and gaps in the SDMs research.The majority of studies failed to present uncertainties and error estimates.However,when model performance estimates are given,the model results will be highly effective,allowing for more assurance in the predictions they make.Furthermore,based on our systematic review,we recommend that in the future rare and endemic SDMs should represent uncertainty levels and estimates of errors in the modelling process. | Ammad Waheed Qazi Zafeer Saqib Muhammad Zaman‑ul‑Haq | 2022 | Ecological Processes2022，11，1： | 1 |
| 5 | Prediction of promiscuous T cell epitopes in RNA dependent RNA polymerase of Chikungunya virus显示文摘Objective: To explore RNA dependent RNA polymerase of Chikungunya virus(CHIKV) and develop T cell based epitopes with high antigenicity and good binding affinity for the human leukocyte antigen(HLA) classes as targets for epitopes based CHIKV vaccine. Methods: In this study we downloaded 371 non-structural protein 4 protein sequences of CHIKV belonging to different regions of the world from the US National Institute of Allergy and Infectious Diseases(NIAID) virus pathogen resource database. All the sequences were aligned by using CLUSTALW software and a consensus sequence was developed by using Uni Pro U Gene Software version 1.2.1. PropredⅠand Propred software were used to predict HLAⅠ and HLAⅡ binding promiscuous epitopes from the consensus sequence of non-structural protein 4 protein. The predicted epitopes were analyzed to determine their antigenicity through Vaxijen server version 2.0. All the HLAⅠ binding epitopes were scanned to determine their immunogenic potential through the Immune Epitope Database(IEDB). All the predicted epitopes of our study were fed to IEDB database to determine whether they had been tested earlier. Results: Twenty two HLA class Ⅱ epitopes and eight HLA classⅠepitopes were predicted. The promiscuous epitopes WMNMEVKII at position 486–494 and VRRLNAVLL at 331–339 were found to bind with 37 and 36 of the 51 HLA class Ⅱ alleles respectively. Epitope MANRSRYQS at position 58–66 and epitopes YQSRKVENM at positions 64–72 were predicted to bind with 12 and 9 HLAⅠI alleles with antigenicity scores of 0.754 9 and 1.013 0 respectively. Epitope YSPPINVRL was predicted to bind 18 HLAⅠ alleles and its antigenicity score was 1.425 9 and immunogenicity score was 0.173 83. This epitope is very useful in the preparation of a universal vaccine against CHIKV infection. Conclusions: Epitopes reported in this study showed promiscuity, antigenicity as well as good binding affinity for the HLA classes. These epitopes will provide the baseline for development of efficacious vaccine for CHIKV. | Yasir Waheed Sher Zaman Safi Muzammil Hasan Najmi Hafsa Aziz Muhammad Imran | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 0 |
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